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Article: Redox regulation of Methionine aminopeptidase 2 activity

TitleRedox regulation of Methionine aminopeptidase 2 activity
Authors
Chiu, JoyceWong, Jason W HHogg, Philip J.
Issue Date2014
Citation
Journal of Biological Chemistry, 2014, v. 289, n. 21, p. 15035-15043 How to Cite?
DOI: http://dx.doi.org/10.1074/jbc.M114.554253
AbstractBackground: The N-terminal methionine in new eukaryote proteins is removed by methionine aminopeptidases, but how these enzymes are regulated is not known. Results: Methionine aminopeptidase 2 contains a single disulfide bond that exists in oxidized and reduced states and influences enzyme function. Conclusion: MetAP2 is regulated by an allosteric disulfide bond. Significance: This has implications for MetAP2 substrate proteins and other similar enzymes. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/251068
ISSN
0021-9258
2020 Impact Factor: 5.157
2023 SCImago Journal Rankings: 1.766
ISI Accession Number ID
WOS:000337248100055

 

DC FieldValueLanguage
dc.contributor.authorChiu, Joyce-
dc.contributor.authorWong, Jason W H-
dc.contributor.authorHogg, Philip J.-
dc.date.accessioned2018-02-01T01:54:29Z-
dc.date.available2018-02-01T01:54:29Z-
dc.date.issued2014-
dc.identifier.citationJournal of Biological Chemistry, 2014, v. 289, n. 21, p. 15035-15043-
dc.identifier.issn0021-9258-
dc.identifier.urihttp://hdl.handle.net/10722/251068-
dc.description.abstractBackground: The N-terminal methionine in new eukaryote proteins is removed by methionine aminopeptidases, but how these enzymes are regulated is not known. Results: Methionine aminopeptidase 2 contains a single disulfide bond that exists in oxidized and reduced states and influences enzyme function. Conclusion: MetAP2 is regulated by an allosteric disulfide bond. Significance: This has implications for MetAP2 substrate proteins and other similar enzymes. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.-
dc.languageeng-
dc.relation.ispartofJournal of Biological Chemistry-
dc.titleRedox regulation of Methionine aminopeptidase 2 activity-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1074/jbc.M114.554253-
dc.identifier.pmid24700462-
dc.identifier.scopuseid_2-s2.0-84901393468-
dc.identifier.volume289-
dc.identifier.issue21-
dc.identifier.spage15035-
dc.identifier.epage15043-
dc.identifier.eissn1083-351X-
dc.identifier.isiWOS:000337248100055-
dc.identifier.issnl0021-9258-

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