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- Publisher Website: 10.1021/ja110226y
- Scopus: eid_2-s2.0-79952271084
- PMID: 21322555
- WOS: WOS:000289455200011
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Article: Noninvasive imaging of cell death using an Hsp90 ligand
Title | Noninvasive imaging of cell death using an Hsp90 ligand |
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Authors | |
Issue Date | 2011 |
Citation | Journal of the American Chemical Society, 2011, v. 133, n. 9, p. 2832-2835 How to Cite? |
Abstract | Cell death plays a central role in normal physiology and in disease. Common to apoptotic and necrotic cell death is the eventual loss of plasma membrane integrity. We have produced a small organoarsenical compound, 4-(N-(S-glutathionylacetyl)amino)phenylarsonous acid, that rapidly accumulates in the cytosol of dying cells coincident with loss of plasma membrane integrity. The compound is retained in the cytosol predominantly by covalent reaction with the 90 kDa heat shock protein (Hsp90), the most abundant molecular chaperone of the eukaryotic cytoplasm. The organoarsenical was tagged with either optical or radioisotope reporting groups to image cell death in cultured cells and in murine tumors ex vivo and in situ. Tumor cell death in mice was noninvasively imaged by SPECT/CT using an 111 In-tagged compound. This versatile compound should enable the imaging of cell death in most experimental settings. © 2011 American Chemical Society. |
Persistent Identifier | http://hdl.handle.net/10722/250965 |
ISSN | 2022 Impact Factor: 15.0 2020 SCImago Journal Rankings: 7.115 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Park, Danielle | - |
dc.contributor.author | Don, Anthony S. | - |
dc.contributor.author | Massamiri, Tania | - |
dc.contributor.author | Karwa, Amol | - |
dc.contributor.author | Warner, Beth | - |
dc.contributor.author | MacDonald, Jan | - |
dc.contributor.author | Hemenway, Christine | - |
dc.contributor.author | Naik, Arati | - |
dc.contributor.author | Kuan, Kah Tiong | - |
dc.contributor.author | Dilda, Pierre J. | - |
dc.contributor.author | Wong, Jason W.H. | - |
dc.contributor.author | Camphausen, Kevin | - |
dc.contributor.author | Chinen, Lori | - |
dc.contributor.author | Dyszlewski, Mary | - |
dc.contributor.author | Hogg, Philip J. | - |
dc.date.accessioned | 2018-02-01T01:54:12Z | - |
dc.date.available | 2018-02-01T01:54:12Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Journal of the American Chemical Society, 2011, v. 133, n. 9, p. 2832-2835 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | http://hdl.handle.net/10722/250965 | - |
dc.description.abstract | Cell death plays a central role in normal physiology and in disease. Common to apoptotic and necrotic cell death is the eventual loss of plasma membrane integrity. We have produced a small organoarsenical compound, 4-(N-(S-glutathionylacetyl)amino)phenylarsonous acid, that rapidly accumulates in the cytosol of dying cells coincident with loss of plasma membrane integrity. The compound is retained in the cytosol predominantly by covalent reaction with the 90 kDa heat shock protein (Hsp90), the most abundant molecular chaperone of the eukaryotic cytoplasm. The organoarsenical was tagged with either optical or radioisotope reporting groups to image cell death in cultured cells and in murine tumors ex vivo and in situ. Tumor cell death in mice was noninvasively imaged by SPECT/CT using an 111 In-tagged compound. This versatile compound should enable the imaging of cell death in most experimental settings. © 2011 American Chemical Society. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of the American Chemical Society | - |
dc.title | Noninvasive imaging of cell death using an Hsp90 ligand | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/ja110226y | - |
dc.identifier.pmid | 21322555 | - |
dc.identifier.scopus | eid_2-s2.0-79952271084 | - |
dc.identifier.volume | 133 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 2832 | - |
dc.identifier.epage | 2835 | - |
dc.identifier.eissn | 1520-5126 | - |
dc.identifier.isi | WOS:000289455200011 | - |
dc.identifier.f1000 | 8649965 | - |
dc.identifier.issnl | 0002-7863 | - |