File Download

There are no files associated with this item.

Supplementary

Conference Paper: The Ten Year Experience of A Regional Specialist Gynaecology Cancer Genetics Clinic with Lynch Syndrome

TitleThe Ten Year Experience of A Regional Specialist Gynaecology Cancer Genetics Clinic with Lynch Syndrome
Authors
Issue Date2017
PublisherThe European Society of Gynaecological Oncology.
Citation
The European Society of Gynaecological Oncology 20th International Meeting, Vienna, Austria, 4-7 November 2017 How to Cite?
AbstractAims: To review the outcomes from a single institution experience of a regional referral practice in Lynch Syndrome (LS) Method: Service review. Surveillance was outpatient hysteroscopy, endometrial biopsy, CA 125 and TV ultrasound. Risk reducing surgery (RRS) was laparoscopic hysterectomy and bilateral salpingo-oophorectomy. Results: Since 2007 60 patients have had RRS and a further 7 patients are undergoing surveillance. There are 18 MLH-1, 17 MSH-2, 7 MSH-6 and 2 PMS-2 mutation carriers having risk reducing surgery with the balance having strong family history. The frequency of surgery is increasing with more referrals. The mean age for RRS is 45 years (range 32-62 yrs). 21 patients opted for surveillance, mean time period 3 years, with the longest screen being 11 years. Forty patients chose RRS, 25 within 6 months of the specialist clinic, 9 within 12 months (1 cancer at surgery aged 54 years), 6 within 24 months (1 cancer at surgery aged 48 years). There has been one ovarian cancer (stage 1A endometrioid) discovered at the time of removing an abnormal ovary at time of colorectal cancer surgery aged 41 years which precipitated diagnosis of LS. Three patients have had endometrial cancer detected at RRS, one stage 2 requiring adjuvant radiotherapy. Prior cancer in carriers include bowel and breast cancer. There have been no deaths. Conclusion: Centralised services provide excellent care for patients with cancer mutations
Persistent Identifierhttp://hdl.handle.net/10722/249948

 

DC FieldValueLanguage
dc.contributor.authorCrawford, R-
dc.contributor.authorNewcombe, B-
dc.contributor.authorBolton, H-
dc.contributor.authorNgu, SF-
dc.contributor.authorFreeman, S-
dc.contributor.authorAddley, H-
dc.contributor.authorJimenez-Linan, M-
dc.contributor.authorArmstrong, R-
dc.contributor.authorTischkowitz, M-
dc.date.accessioned2017-12-20T09:18:28Z-
dc.date.available2017-12-20T09:18:28Z-
dc.date.issued2017-
dc.identifier.citationThe European Society of Gynaecological Oncology 20th International Meeting, Vienna, Austria, 4-7 November 2017-
dc.identifier.urihttp://hdl.handle.net/10722/249948-
dc.description.abstractAims: To review the outcomes from a single institution experience of a regional referral practice in Lynch Syndrome (LS) Method: Service review. Surveillance was outpatient hysteroscopy, endometrial biopsy, CA 125 and TV ultrasound. Risk reducing surgery (RRS) was laparoscopic hysterectomy and bilateral salpingo-oophorectomy. Results: Since 2007 60 patients have had RRS and a further 7 patients are undergoing surveillance. There are 18 MLH-1, 17 MSH-2, 7 MSH-6 and 2 PMS-2 mutation carriers having risk reducing surgery with the balance having strong family history. The frequency of surgery is increasing with more referrals. The mean age for RRS is 45 years (range 32-62 yrs). 21 patients opted for surveillance, mean time period 3 years, with the longest screen being 11 years. Forty patients chose RRS, 25 within 6 months of the specialist clinic, 9 within 12 months (1 cancer at surgery aged 54 years), 6 within 24 months (1 cancer at surgery aged 48 years). There has been one ovarian cancer (stage 1A endometrioid) discovered at the time of removing an abnormal ovary at time of colorectal cancer surgery aged 41 years which precipitated diagnosis of LS. Three patients have had endometrial cancer detected at RRS, one stage 2 requiring adjuvant radiotherapy. Prior cancer in carriers include bowel and breast cancer. There have been no deaths. Conclusion: Centralised services provide excellent care for patients with cancer mutations-
dc.languageeng-
dc.publisherThe European Society of Gynaecological Oncology. -
dc.relation.ispartofThe European Society of Gynaecological Oncology International Meeting, ESGO 2017-
dc.titleThe Ten Year Experience of A Regional Specialist Gynaecology Cancer Genetics Clinic with Lynch Syndrome-
dc.typeConference_Paper-
dc.identifier.emailNgu, SF: ngusiewf@hku.hk-
dc.identifier.authorityNgu, SF=rp01367-
dc.identifier.hkuros283538-
dc.publisher.placeVienna, Austria-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats