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- Publisher Website: 10.1054/bjom.1999.0130
- Scopus: eid_2-s2.0-0032709289
- PMID: 10577752
- WOS: WOS:000083390300006
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Article: Mapping dynamic epithelial cell proliferative activity within the oral cavity of man: A new insight into carcinogenesis?
Title | Mapping dynamic epithelial cell proliferative activity within the oral cavity of man: A new insight into carcinogenesis? |
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Authors | |
Issue Date | 1999 |
Citation | British Journal of Oral and Maxillofacial Surgery, 1999, v. 37, n. 5, p. 377-383 How to Cite? |
Abstract | Our aim was to characterize epithelial cell proliferative activity within the oral cavity and to find out if there were differences between sites with high and low incidence of cancer. A total of 105 samples of clinically normal mucosa were harvested from various intra-oral sites. Excised specimens were incubated in vitro with tritiated thymidine and bromodeoxyuridine to 'double label' cells undergoing DNA synthesis, and enable calculation of the duration of S phase and estimation of variables of cell flux to and from S. Mean labelling indices (percentage of cells within the S phase of the cell cycle) were highest in the floor of mouth (12.3%) and ventral tongue (10.1%), while activity was lowest in the dorsum of tongue (4.3%) and the palate (7.2%), P < 0.001). In general, both cell influx and the duration of S increased proportionally to the labelling index. Sites with a high incidence of cancer were characterized by high labelling indices, increased cell influx and a prolonged S phase. |
Persistent Identifier | http://hdl.handle.net/10722/249142 |
ISSN | 2023 Impact Factor: 1.7 2023 SCImago Journal Rankings: 0.572 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Thomson, P. J. | - |
dc.contributor.author | Potten, C. S. | - |
dc.contributor.author | Appleton, D. R. | - |
dc.date.accessioned | 2017-10-27T05:59:13Z | - |
dc.date.available | 2017-10-27T05:59:13Z | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | British Journal of Oral and Maxillofacial Surgery, 1999, v. 37, n. 5, p. 377-383 | - |
dc.identifier.issn | 0266-4356 | - |
dc.identifier.uri | http://hdl.handle.net/10722/249142 | - |
dc.description.abstract | Our aim was to characterize epithelial cell proliferative activity within the oral cavity and to find out if there were differences between sites with high and low incidence of cancer. A total of 105 samples of clinically normal mucosa were harvested from various intra-oral sites. Excised specimens were incubated in vitro with tritiated thymidine and bromodeoxyuridine to 'double label' cells undergoing DNA synthesis, and enable calculation of the duration of S phase and estimation of variables of cell flux to and from S. Mean labelling indices (percentage of cells within the S phase of the cell cycle) were highest in the floor of mouth (12.3%) and ventral tongue (10.1%), while activity was lowest in the dorsum of tongue (4.3%) and the palate (7.2%), P < 0.001). In general, both cell influx and the duration of S increased proportionally to the labelling index. Sites with a high incidence of cancer were characterized by high labelling indices, increased cell influx and a prolonged S phase. | - |
dc.language | eng | - |
dc.relation.ispartof | British Journal of Oral and Maxillofacial Surgery | - |
dc.title | Mapping dynamic epithelial cell proliferative activity within the oral cavity of man: A new insight into carcinogenesis? | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1054/bjom.1999.0130 | - |
dc.identifier.pmid | 10577752 | - |
dc.identifier.scopus | eid_2-s2.0-0032709289 | - |
dc.identifier.volume | 37 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 377 | - |
dc.identifier.epage | 383 | - |
dc.identifier.isi | WOS:000083390300006 | - |
dc.identifier.issnl | 0266-4356 | - |