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- Publisher Website: 10.1007/978-1-59745-039-3_26
- Scopus: eid_2-s2.0-84891444139
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Book Chapter: Chromosome-engineered mouse models
| Title | Chromosome-engineered mouse models |
|---|---|
| Authors | |
| Issue Date | 2006 |
| Citation | Genomic Disorders: The Genomic Basis of Disease, 2006, p. 373-387 How to Cite? |
| Abstract | Chromosome rearrangements cause genomic disorders and cancer in human. Region-specific low-copy repeats (LCRs) can mediate nonallelic homologous recombination (NAHR) that results in chromosome rearrangements. Using the Cre-loxP site-specific recombination system, chromosome rearrangements that cause genomic disorders and cancer can be recapitulated in the mouse. Technology advancements in mouse genetics, such as recombineering, will undoubtedly facilitate modeling genetic changes associated with genomic disorders in the mouse. © 2006 Humana Press Inc. |
| Persistent Identifier | http://hdl.handle.net/10722/249092 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Liu, Pentao | - |
| dc.date.accessioned | 2017-10-27T05:59:05Z | - |
| dc.date.available | 2017-10-27T05:59:05Z | - |
| dc.date.issued | 2006 | - |
| dc.identifier.citation | Genomic Disorders: The Genomic Basis of Disease, 2006, p. 373-387 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/249092 | - |
| dc.description.abstract | Chromosome rearrangements cause genomic disorders and cancer in human. Region-specific low-copy repeats (LCRs) can mediate nonallelic homologous recombination (NAHR) that results in chromosome rearrangements. Using the Cre-loxP site-specific recombination system, chromosome rearrangements that cause genomic disorders and cancer can be recapitulated in the mouse. Technology advancements in mouse genetics, such as recombineering, will undoubtedly facilitate modeling genetic changes associated with genomic disorders in the mouse. © 2006 Humana Press Inc. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Genomic Disorders: The Genomic Basis of Disease | - |
| dc.title | Chromosome-engineered mouse models | - |
| dc.type | Book_Chapter | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1007/978-1-59745-039-3_26 | - |
| dc.identifier.scopus | eid_2-s2.0-84891444139 | - |
| dc.identifier.spage | 373 | - |
| dc.identifier.epage | 387 | - |