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Article: Clinical outcome following oral potentially malignant disorder treatment: A 100 patient cohort study
Title | Clinical outcome following oral potentially malignant disorder treatment: A 100 patient cohort study |
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Authors | |
Issue Date | 2013 |
Citation | International Journal of Dentistry, 2013, v. 2013 How to Cite? |
Abstract | Oral potentially malignant disorders (PMDs) are at risk of transforming to invasive squamous cell carcinoma (SCC), but controversy exists over their management and the precise role of interventional treatment. In this study, a cohort of 100 patients presenting with new, single oral dysplastic PMD lesions were followed for up to 10 years following laser excision. PMDs presented primarily as homogeneous leukoplakias on floor of mouth and ventrolateral tongue sites and showed mainly high-grade dysplasia following analysis of excision specimens. Sixty-two patients were disease-free at the time of the most recent followup, whilst 17 experienced same site PMD recurrence, 14 developed further PMDs at new sites, 5 underwent same site malignant transformation, and 2 developed SCC at new oral sites. Whilst laser excision is an effective therapeutic tool in PMD management, prolonged patient followup and active mucosal surveillance together with clear definitions of clinical outcomes are all essential prerequisites for successful interventional management. Multicentre, prospective, and randomised trials of PMD treatment intervention are urgently required to determine optimal management strategies. © 2013 A. Diajil et al. |
Persistent Identifier | http://hdl.handle.net/10722/249077 |
ISSN | 2023 Impact Factor: 1.9 2023 SCImago Journal Rankings: 0.492 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Diajil, A. | - |
dc.contributor.author | Robinson, C. M. | - |
dc.contributor.author | Sloan, P. | - |
dc.contributor.author | Thomson, P. J. | - |
dc.date.accessioned | 2017-10-27T05:59:02Z | - |
dc.date.available | 2017-10-27T05:59:02Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | International Journal of Dentistry, 2013, v. 2013 | - |
dc.identifier.issn | 1687-8728 | - |
dc.identifier.uri | http://hdl.handle.net/10722/249077 | - |
dc.description.abstract | Oral potentially malignant disorders (PMDs) are at risk of transforming to invasive squamous cell carcinoma (SCC), but controversy exists over their management and the precise role of interventional treatment. In this study, a cohort of 100 patients presenting with new, single oral dysplastic PMD lesions were followed for up to 10 years following laser excision. PMDs presented primarily as homogeneous leukoplakias on floor of mouth and ventrolateral tongue sites and showed mainly high-grade dysplasia following analysis of excision specimens. Sixty-two patients were disease-free at the time of the most recent followup, whilst 17 experienced same site PMD recurrence, 14 developed further PMDs at new sites, 5 underwent same site malignant transformation, and 2 developed SCC at new oral sites. Whilst laser excision is an effective therapeutic tool in PMD management, prolonged patient followup and active mucosal surveillance together with clear definitions of clinical outcomes are all essential prerequisites for successful interventional management. Multicentre, prospective, and randomised trials of PMD treatment intervention are urgently required to determine optimal management strategies. © 2013 A. Diajil et al. | - |
dc.language | eng | - |
dc.relation.ispartof | International Journal of Dentistry | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Clinical outcome following oral potentially malignant disorder treatment: A 100 patient cohort study | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1155/2013/809248 | - |
dc.identifier.scopus | eid_2-s2.0-84880891113 | - |
dc.identifier.volume | 2013 | - |
dc.identifier.spage | null | - |
dc.identifier.epage | null | - |
dc.identifier.eissn | 1687-8736 | - |
dc.identifier.isi | WOS:000214310900056 | - |
dc.identifier.issnl | 1687-8728 | - |