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Article: Bcl11a Controls Flt3 Expression in Early Hematopoietic Progenitors and Is Required for pDC Development In Vivo

TitleBcl11a Controls Flt3 Expression in Early Hematopoietic Progenitors and Is Required for pDC Development In Vivo
Authors
Wu, XiaodiSatpathy, Ansuman T.Kc, WumeshLiu, PentaoMurphy, Theresa L.Murphy, Kenneth M.
Issue Date2013
Citation
PLoS ONE, 2013, v. 8, n. 5 How to Cite?
DOI: http://dx.doi.org/10.1371/journal.pone.0064800
AbstractBcl11a is a transcription factor known to regulate lymphoid and erythroid development. Recent bioinformatic analysis of global gene expression patterns has suggested a role for Bcl11a in the development of dendritic cell (DC) lineages. We tested this hypothesis by analyzing the development of DC and other lineages in Bcl11a -/- mice. We found that Bcl11a was required for expression of IL-7 receptor (IL-7R) and Flt3 in early hematopoietic progenitor cells. In addition, we found severely decreased numbers of plasmacytoid dendritic cells (pDCs) in Bcl11a -/- fetal livers and in the bone marrow of Bcl11a -/- fetal liver chimeras. Moreover, Bcl11a -/- cells showed severely impaired in vitro development of Flt3L-derived pDCs and classical DCs (cDCs). In contrast, we found normal in vitro development of DCs from Bcl11a -/- fetal liver cells treated with GM-CSF. These results suggest that the persistent cDC development observed in Bcl11a -/- fetal liver chimeras reflects derivation from a Bcl11a- and Flt3-independent pathway in vivo. © 2013 Wu et al.
Persistent Identifierhttp://hdl.handle.net/10722/249075
ISI Accession Number ID
WOS:000319799900108

 

DC FieldValueLanguage
dc.contributor.authorWu, Xiaodi-
dc.contributor.authorSatpathy, Ansuman T.-
dc.contributor.authorKc, Wumesh-
dc.contributor.authorLiu, Pentao-
dc.contributor.authorMurphy, Theresa L.-
dc.contributor.authorMurphy, Kenneth M.-
dc.date.accessioned2017-10-27T05:59:02Z-
dc.date.available2017-10-27T05:59:02Z-
dc.date.issued2013-
dc.identifier.citationPLoS ONE, 2013, v. 8, n. 5-
dc.identifier.urihttp://hdl.handle.net/10722/249075-
dc.description.abstractBcl11a is a transcription factor known to regulate lymphoid and erythroid development. Recent bioinformatic analysis of global gene expression patterns has suggested a role for Bcl11a in the development of dendritic cell (DC) lineages. We tested this hypothesis by analyzing the development of DC and other lineages in Bcl11a -/- mice. We found that Bcl11a was required for expression of IL-7 receptor (IL-7R) and Flt3 in early hematopoietic progenitor cells. In addition, we found severely decreased numbers of plasmacytoid dendritic cells (pDCs) in Bcl11a -/- fetal livers and in the bone marrow of Bcl11a -/- fetal liver chimeras. Moreover, Bcl11a -/- cells showed severely impaired in vitro development of Flt3L-derived pDCs and classical DCs (cDCs). In contrast, we found normal in vitro development of DCs from Bcl11a -/- fetal liver cells treated with GM-CSF. These results suggest that the persistent cDC development observed in Bcl11a -/- fetal liver chimeras reflects derivation from a Bcl11a- and Flt3-independent pathway in vivo. © 2013 Wu et al.-
dc.languageeng-
dc.relation.ispartofPLoS ONE-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleBcl11a Controls Flt3 Expression in Early Hematopoietic Progenitors and Is Required for pDC Development In Vivo-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0064800-
dc.identifier.pmid23741395-
dc.identifier.scopuseid_2-s2.0-84878578156-
dc.identifier.volume8-
dc.identifier.issue5-
dc.identifier.spagenull-
dc.identifier.epagenull-
dc.identifier.eissn1932-6203-
dc.identifier.isiWOS:000319799900108-
dc.identifier.issnl1932-6203-

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