File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Risk of upper aerodigestive tract cancer and type of alcoholic beverage: A European multicenter case-control study

TitleRisk of upper aerodigestive tract cancer and type of alcoholic beverage: A European multicenter case-control study
Authors
KeywordsHead and neck cancer
Alcohol
Beer
Cancer
Epidemiology
Liquor
Upper aerodigestive tract cancer
Wine
Issue Date2012
Citation
European Journal of Epidemiology, 2012, v. 27, n. 7, p. 499-517 How to Cite?
AbstractThe general relationship between cancers of the upper aerodigestive tract (UADT) and alcohol drinking is established. Nevertheless, it is uncertain whether different types of alcoholic beverages (wine, beer and liquor) carry different UADT cancer risks. Our study included 2,001 UADT cancer cases and 2,125 controls from 14 centres in 10 European countries. All cases were histologically or cytologically confirmed squamous cell carcinomas. Controls were frequency matched by sex, age and centre. Logistic regression models were used to estimate odds ratios (OR) and 95 % confidence intervals (95 %CI) adjusted for age, sex, centre, education level, vegetable and fruit intake, tobacco smoking and alcohol drinking, where appropriate. Risk of beverage-specific alcohol consumption were calculated among 'pure drinker' who consumed one beverage type exclusively, among 'predominant drinkers' who consumed one beverage type to more than 66 % and among 'mixed drinkers' who consumed more than one beverage type to similar proportions. Compared to never drinkers and adjusted for cumulative alcohol consumption, the OR and 95 %CI for wine, beer and liquor drinking, respectively, were 1.24 (0.86, 1.78), 1.54 (1.05, 2.27) and 0.94 (0.53, 1.64) among 'pure drinkers' (p value for heterogeneity across beverage types = 0.306), 1.05 (0.76,1.47), 1.25 (0.87,1.79) and 1.43 (0.95, 2.16) among 'predominant drinkers' (p value = 0.456), and 1.09 (0.79, 1.50), 1.20 (0.88, 1.63) and 1.12 (0.82, 1.53) among 'mixed drinkers' (p value = 0.889). Risk of UADT cancer increased with increasing consumption of all three alcohol beverage types. Our findings underscore the strong and comparable carcinogenic effect of ethanol in wine, beer and liquor on organs of the UADT. © Springer Science+Business Media B.V. 2012.
Persistent Identifierhttp://hdl.handle.net/10722/249069
ISSN
2023 Impact Factor: 7.7
2023 SCImago Journal Rankings: 3.186
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMarron, Manuela-
dc.contributor.authorBoffetta, Paolo-
dc.contributor.authorMøller, Henrik-
dc.contributor.authorAhrens, Wolfgang-
dc.contributor.authorPohlabeln, Hermann-
dc.contributor.authorBenhamou, Simone-
dc.contributor.authorBouchardy, Christine-
dc.contributor.authorLagiou, Pagona-
dc.contributor.authorLagiou, Areti-
dc.contributor.authorSlámová, Alena-
dc.contributor.authorSchejbalová, Miriam-
dc.contributor.authorMerletti, Franco-
dc.contributor.authorRichiardi, Lorenzo-
dc.contributor.authorKjaerheim, Kristina-
dc.contributor.authorAgudo, Antonio-
dc.contributor.authorCastellsague, Xavier-
dc.contributor.authorMacfarlane, Tatiana Victorovna-
dc.contributor.authorMacfarlane, Gary John-
dc.contributor.authorTalamini, Renato-
dc.contributor.authorBarzan, Luigi-
dc.contributor.authorCanova, Cristina-
dc.contributor.authorSimonato, Lorenzo-
dc.contributor.authorBiggs, Anne Marie-
dc.contributor.authorThomson, Peter-
dc.contributor.authorConway, David Ian-
dc.contributor.authorMcKinney, Patricia Ann-
dc.contributor.authorZnaor, Ariana-
dc.contributor.authorHealy, Claire Marie-
dc.contributor.authorMcCartan, Bernard Eugene-
dc.contributor.authorBrennan, Paul-
dc.contributor.authorHashibe, Mia-
dc.date.accessioned2017-10-27T05:59:01Z-
dc.date.available2017-10-27T05:59:01Z-
dc.date.issued2012-
dc.identifier.citationEuropean Journal of Epidemiology, 2012, v. 27, n. 7, p. 499-517-
dc.identifier.issn0393-2990-
dc.identifier.urihttp://hdl.handle.net/10722/249069-
dc.description.abstractThe general relationship between cancers of the upper aerodigestive tract (UADT) and alcohol drinking is established. Nevertheless, it is uncertain whether different types of alcoholic beverages (wine, beer and liquor) carry different UADT cancer risks. Our study included 2,001 UADT cancer cases and 2,125 controls from 14 centres in 10 European countries. All cases were histologically or cytologically confirmed squamous cell carcinomas. Controls were frequency matched by sex, age and centre. Logistic regression models were used to estimate odds ratios (OR) and 95 % confidence intervals (95 %CI) adjusted for age, sex, centre, education level, vegetable and fruit intake, tobacco smoking and alcohol drinking, where appropriate. Risk of beverage-specific alcohol consumption were calculated among 'pure drinker' who consumed one beverage type exclusively, among 'predominant drinkers' who consumed one beverage type to more than 66 % and among 'mixed drinkers' who consumed more than one beverage type to similar proportions. Compared to never drinkers and adjusted for cumulative alcohol consumption, the OR and 95 %CI for wine, beer and liquor drinking, respectively, were 1.24 (0.86, 1.78), 1.54 (1.05, 2.27) and 0.94 (0.53, 1.64) among 'pure drinkers' (p value for heterogeneity across beverage types = 0.306), 1.05 (0.76,1.47), 1.25 (0.87,1.79) and 1.43 (0.95, 2.16) among 'predominant drinkers' (p value = 0.456), and 1.09 (0.79, 1.50), 1.20 (0.88, 1.63) and 1.12 (0.82, 1.53) among 'mixed drinkers' (p value = 0.889). Risk of UADT cancer increased with increasing consumption of all three alcohol beverage types. Our findings underscore the strong and comparable carcinogenic effect of ethanol in wine, beer and liquor on organs of the UADT. © Springer Science+Business Media B.V. 2012.-
dc.languageeng-
dc.relation.ispartofEuropean Journal of Epidemiology-
dc.subjectHead and neck cancer-
dc.subjectAlcohol-
dc.subjectBeer-
dc.subjectCancer-
dc.subjectEpidemiology-
dc.subjectLiquor-
dc.subjectUpper aerodigestive tract cancer-
dc.subjectWine-
dc.titleRisk of upper aerodigestive tract cancer and type of alcoholic beverage: A European multicenter case-control study-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s10654-012-9699-1-
dc.identifier.pmid22692594-
dc.identifier.scopuseid_2-s2.0-84866018691-
dc.identifier.volume27-
dc.identifier.issue7-
dc.identifier.spage499-
dc.identifier.epage517-
dc.identifier.eissn1573-7284-
dc.identifier.isiWOS:000307250900003-
dc.identifier.issnl0393-2990-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats