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- Publisher Website: 10.1159/000331867
- Scopus: eid_2-s2.0-80053926500
- PMID: 21996640
- WOS: WOS:000298322600005
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Article: Metformin-associated lactic acidosis in Chinese patients with type II diabetes
Title | Metformin-associated lactic acidosis in Chinese patients with type II diabetes |
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Authors | |
Keywords | Lactic acidosis Biguanide Antidiabetic agent Toxicology Poisoning Metformin-associated lactic acidosis Metformin |
Issue Date | 2011 |
Citation | Pharmacology, 2011, v. 88, n. 5-6, p. 260-265 How to Cite? |
Abstract | Metformin is a widely used antidiabetic agent that is generally considered safe. However, metformin-associated lactic acidosis (MALA), though not common, occurs from time to time and results in significantly high mortality. A series of 23 MALA cases in a local major hospital in Hong Kong is reported in this article to demonstrate the epidemiological data, risk factors, clinical features as well as the clinical outcomes for better understanding of this disease entity. It is the first MALA case series in which plasma metformin levels were assessed. However, the results show that plasma metformin levels in MALA bear no diagnostic and prognostic values. Risk factors of mortality were identified as shock and high plasma lactate levels. The majority of patients were found to have significantly raised creatinine versus a normal baseline value before the acute illness. Concomitant illnesses taking place alongside MALA were common. With a high utility rate of renal replacement therapy (82.6%) in the study group, the mortality rate was 30.4%. Copyright © 2011 S. Karger AG, Basel. |
Persistent Identifier | http://hdl.handle.net/10722/249053 |
ISSN | 2021 Impact Factor: 3.429 2020 SCImago Journal Rankings: 0.510 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yeung, Chun Wing | - |
dc.contributor.author | Chung, Ho Yin | - |
dc.contributor.author | Fong, Bonnie Mei Wah | - |
dc.contributor.author | Tsai, Nga Wing | - |
dc.contributor.author | Chan, Wai Ming | - |
dc.contributor.author | Siu, Tak Shing | - |
dc.contributor.author | Tam, Sidney | - |
dc.contributor.author | Tsuchiurai, Sik Hon | - |
dc.date.accessioned | 2017-10-27T05:58:58Z | - |
dc.date.available | 2017-10-27T05:58:58Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Pharmacology, 2011, v. 88, n. 5-6, p. 260-265 | - |
dc.identifier.issn | 0031-7012 | - |
dc.identifier.uri | http://hdl.handle.net/10722/249053 | - |
dc.description.abstract | Metformin is a widely used antidiabetic agent that is generally considered safe. However, metformin-associated lactic acidosis (MALA), though not common, occurs from time to time and results in significantly high mortality. A series of 23 MALA cases in a local major hospital in Hong Kong is reported in this article to demonstrate the epidemiological data, risk factors, clinical features as well as the clinical outcomes for better understanding of this disease entity. It is the first MALA case series in which plasma metformin levels were assessed. However, the results show that plasma metformin levels in MALA bear no diagnostic and prognostic values. Risk factors of mortality were identified as shock and high plasma lactate levels. The majority of patients were found to have significantly raised creatinine versus a normal baseline value before the acute illness. Concomitant illnesses taking place alongside MALA were common. With a high utility rate of renal replacement therapy (82.6%) in the study group, the mortality rate was 30.4%. Copyright © 2011 S. Karger AG, Basel. | - |
dc.language | eng | - |
dc.relation.ispartof | Pharmacology | - |
dc.subject | Lactic acidosis | - |
dc.subject | Biguanide | - |
dc.subject | Antidiabetic agent | - |
dc.subject | Toxicology | - |
dc.subject | Poisoning | - |
dc.subject | Metformin-associated lactic acidosis | - |
dc.subject | Metformin | - |
dc.title | Metformin-associated lactic acidosis in Chinese patients with type II diabetes | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1159/000331867 | - |
dc.identifier.pmid | 21996640 | - |
dc.identifier.scopus | eid_2-s2.0-80053926500 | - |
dc.identifier.volume | 88 | - |
dc.identifier.issue | 5-6 | - |
dc.identifier.spage | 260 | - |
dc.identifier.epage | 265 | - |
dc.identifier.eissn | 1423-0313 | - |
dc.identifier.isi | WOS:000298322600005 | - |
dc.identifier.issnl | 0031-7012 | - |