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Article: Stella-Cre mice are highly efficient Cre deleters

TitleStella-Cre mice are highly efficient Cre deleters
Authors
Liu, HuiWang, WeiChew, Su KitLee, Song ChoonLi, JuanVassiliou, George S.Green, TonyFutreal, P. AndrewBradley, AllanZhang, ShujunLiu, Pentao
KeywordsStella
Knock-in
Cre-loxP recombination
Issue Date2011
Citation
Genesis, 2011, v. 49, n. 8, p. 689-695 How to Cite?
DOI: http://dx.doi.org/10.1002/dvg.20741
AbstractCre-loxP recombination is widely used for genetic manipulation of the mouse genome. Here, we report generation and characterization of a new Cre line, Stella-Cre, where Cre expression cassette was targeted to the 3' UTR of the Stella locus. Stella is specific ally expressed in preimplantation embryos and in the germline. Cre-loxP recombination efficiency in Stella-Cre mice was investigated at several genomic loci including Rosa26, Jak2, and Npm1. At all the loci examined, we observed 100% Cre-loxP recombination efficiency in the embryos and in the germline. Thus, Stella-Cre mice serve as a very efficient deleter line. genesis 49:689-695, 2011. © 2011 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/249051
ISSN
1526-954X
2023 Impact Factor: 2.4
2023 SCImago Journal Rankings: 0.757
ISI Accession Number ID
WOS:000294177600006

 

DC FieldValueLanguage
dc.contributor.authorLiu, Hui-
dc.contributor.authorWang, Wei-
dc.contributor.authorChew, Su Kit-
dc.contributor.authorLee, Song Choon-
dc.contributor.authorLi, Juan-
dc.contributor.authorVassiliou, George S.-
dc.contributor.authorGreen, Tony-
dc.contributor.authorFutreal, P. Andrew-
dc.contributor.authorBradley, Allan-
dc.contributor.authorZhang, Shujun-
dc.contributor.authorLiu, Pentao-
dc.date.accessioned2017-10-27T05:58:58Z-
dc.date.available2017-10-27T05:58:58Z-
dc.date.issued2011-
dc.identifier.citationGenesis, 2011, v. 49, n. 8, p. 689-695-
dc.identifier.issn1526-954X-
dc.identifier.urihttp://hdl.handle.net/10722/249051-
dc.description.abstractCre-loxP recombination is widely used for genetic manipulation of the mouse genome. Here, we report generation and characterization of a new Cre line, Stella-Cre, where Cre expression cassette was targeted to the 3' UTR of the Stella locus. Stella is specific ally expressed in preimplantation embryos and in the germline. Cre-loxP recombination efficiency in Stella-Cre mice was investigated at several genomic loci including Rosa26, Jak2, and Npm1. At all the loci examined, we observed 100% Cre-loxP recombination efficiency in the embryos and in the germline. Thus, Stella-Cre mice serve as a very efficient deleter line. genesis 49:689-695, 2011. © 2011 Wiley-Liss, Inc.-
dc.languageeng-
dc.relation.ispartofGenesis-
dc.subjectStella-
dc.subjectKnock-in-
dc.subjectCre-loxP recombination-
dc.titleStella-Cre mice are highly efficient Cre deleters-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/dvg.20741-
dc.identifier.pmid21786403-
dc.identifier.scopuseid_2-s2.0-80051564408-
dc.identifier.volume49-
dc.identifier.issue8-
dc.identifier.spage689-
dc.identifier.epage695-
dc.identifier.eissn1526-968X-
dc.identifier.isiWOS:000294177600006-
dc.identifier.issnl1526-954X-

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