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- Publisher Website: 10.1111/j.1600-065X.2010.00953.x
- Scopus: eid_2-s2.0-77958553288
- PMID: 20969590
- WOS: WOS:000283509100011
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Article: Critical roles of Bcl11b in T-cell development and maintenance of T-cell identity
Title | Critical roles of Bcl11b in T-cell development and maintenance of T-cell identity |
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Authors | |
Keywords | Immunotherapy Identity Transcription factor Bcl11b Natural killer Reprogramming T cells |
Issue Date | 2010 |
Citation | Immunological Reviews, 2010, v. 238, n. 1, p. 138-149 How to Cite? |
Abstract | T-cell development primarily occurs in the thymus and involves in the interactions of many important transcription factors. Until recently, no single transcription factor has been identified to be essential for T-cell lineage commitment or maintenance of T-cell identity. Recent studies have now identified the zinc finger transcription factor Bcl11b to be essential for T-cell development and for maintenance of T-cell identity. Remarkably, T cells acquire NK cell properties upon Bcl11b deletion. These reprogrammed cells have unique properties in proliferation, cytokine dependency and killing target cells, and may therefore provide a new cell source for some cell-based therapies. © 2010 John Wiley & Sons A/S. |
Persistent Identifier | http://hdl.handle.net/10722/249043 |
ISSN | 2023 Impact Factor: 7.5 2023 SCImago Journal Rankings: 3.554 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Liu, Pentao | - |
dc.contributor.author | Li, Peng | - |
dc.contributor.author | Burke, Shannon | - |
dc.date.accessioned | 2017-10-27T05:58:57Z | - |
dc.date.available | 2017-10-27T05:58:57Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Immunological Reviews, 2010, v. 238, n. 1, p. 138-149 | - |
dc.identifier.issn | 0105-2896 | - |
dc.identifier.uri | http://hdl.handle.net/10722/249043 | - |
dc.description.abstract | T-cell development primarily occurs in the thymus and involves in the interactions of many important transcription factors. Until recently, no single transcription factor has been identified to be essential for T-cell lineage commitment or maintenance of T-cell identity. Recent studies have now identified the zinc finger transcription factor Bcl11b to be essential for T-cell development and for maintenance of T-cell identity. Remarkably, T cells acquire NK cell properties upon Bcl11b deletion. These reprogrammed cells have unique properties in proliferation, cytokine dependency and killing target cells, and may therefore provide a new cell source for some cell-based therapies. © 2010 John Wiley & Sons A/S. | - |
dc.language | eng | - |
dc.relation.ispartof | Immunological Reviews | - |
dc.subject | Immunotherapy | - |
dc.subject | Identity | - |
dc.subject | Transcription factor | - |
dc.subject | Bcl11b | - |
dc.subject | Natural killer | - |
dc.subject | Reprogramming | - |
dc.subject | T cells | - |
dc.title | Critical roles of Bcl11b in T-cell development and maintenance of T-cell identity | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/j.1600-065X.2010.00953.x | - |
dc.identifier.pmid | 20969590 | - |
dc.identifier.scopus | eid_2-s2.0-77958553288 | - |
dc.identifier.volume | 238 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 138 | - |
dc.identifier.epage | 149 | - |
dc.identifier.eissn | 1600-065X | - |
dc.identifier.isi | WOS:000283509100011 | - |
dc.identifier.issnl | 0105-2896 | - |