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- Publisher Website: 10.1016/j.devcel.2010.06.015
- Scopus: eid_2-s2.0-77954945373
- PMID: 20643348
- WOS: WOS:000280469100008
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Article: The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals
Title | The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals |
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Authors | |
Keywords | Humdisease Devbio |
Issue Date | 2010 |
Citation | Developmental Cell, 2010, v. 19, n. 1, p. 27-38 How to Cite? |
Abstract | The conserved Hippo signaling pathway regulates organ size in Drosophila and mammals. While a core kinase cascade leading from the protein kinase Hippo (Hpo) (Mst1 and Mst2 in mammals) to the transcription coactivator Yorkie (Yki) (YAP in mammals) has been established, upstream regulators of the Hippo kinase cascade are less well defined, especially in mammals. Using conditional knockout mice, we demonstrate that the Merlin/NF2 tumor suppressor and the YAP oncoprotein function antagonistically to regulate liver development. While inactivation of Yap led to loss of hepatocytes and biliary epithelial cells, inactivation of Nf2 led to hepatocellular carcinoma and bile duct hamartoma. Strikingly, the Nf2-deficient phenotypes in multiple tissues were largely suppressed by heterozygous deletion of Yap, suggesting that YAP is a major effector of Merlin/NF2 in growth regulation. Our studies link Merlin/NF2 to mammalian Hippo signaling and implicate YAP activation as a mediator of pathologies relevant to Neurofibromatosis 2. © 2010 Elsevier Inc. |
Persistent Identifier | http://hdl.handle.net/10722/249038 |
ISSN | 2023 Impact Factor: 10.7 2023 SCImago Journal Rankings: 5.828 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhang, Nailing | - |
dc.contributor.author | Bai, Haibo | - |
dc.contributor.author | David, Karen K. | - |
dc.contributor.author | Dong, Jixin | - |
dc.contributor.author | Zheng, Yonggang | - |
dc.contributor.author | Cai, Jing | - |
dc.contributor.author | Giovannini, Marco | - |
dc.contributor.author | Liu, Pentao | - |
dc.contributor.author | Anders, Robert A. | - |
dc.contributor.author | Pan, Duojia | - |
dc.date.accessioned | 2017-10-27T05:58:56Z | - |
dc.date.available | 2017-10-27T05:58:56Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Developmental Cell, 2010, v. 19, n. 1, p. 27-38 | - |
dc.identifier.issn | 1534-5807 | - |
dc.identifier.uri | http://hdl.handle.net/10722/249038 | - |
dc.description.abstract | The conserved Hippo signaling pathway regulates organ size in Drosophila and mammals. While a core kinase cascade leading from the protein kinase Hippo (Hpo) (Mst1 and Mst2 in mammals) to the transcription coactivator Yorkie (Yki) (YAP in mammals) has been established, upstream regulators of the Hippo kinase cascade are less well defined, especially in mammals. Using conditional knockout mice, we demonstrate that the Merlin/NF2 tumor suppressor and the YAP oncoprotein function antagonistically to regulate liver development. While inactivation of Yap led to loss of hepatocytes and biliary epithelial cells, inactivation of Nf2 led to hepatocellular carcinoma and bile duct hamartoma. Strikingly, the Nf2-deficient phenotypes in multiple tissues were largely suppressed by heterozygous deletion of Yap, suggesting that YAP is a major effector of Merlin/NF2 in growth regulation. Our studies link Merlin/NF2 to mammalian Hippo signaling and implicate YAP activation as a mediator of pathologies relevant to Neurofibromatosis 2. © 2010 Elsevier Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Developmental Cell | - |
dc.subject | Humdisease | - |
dc.subject | Devbio | - |
dc.title | The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/j.devcel.2010.06.015 | - |
dc.identifier.pmid | 20643348 | - |
dc.identifier.scopus | eid_2-s2.0-77954945373 | - |
dc.identifier.volume | 19 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 27 | - |
dc.identifier.epage | 38 | - |
dc.identifier.isi | WOS:000280469100008 | - |
dc.identifier.issnl | 1534-5807 | - |