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- Publisher Website: 10.1016/j.ijom.2005.11.003
- Scopus: eid_2-s2.0-33646496590
- PMID: 16442264
- WOS: WOS:000238103500008
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Article: Improved sedation for oral surgery by combining nitrous oxide and intravenous Midazolam: a randomized, controlled trial
Title | Improved sedation for oral surgery by combining nitrous oxide and intravenous Midazolam: a randomized, controlled trial |
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Authors | |
Issue Date | 2006 |
Citation | International Journal of Oral and Maxillofacial Surgery, 2006, v. 35, n. 6, p. 522-527 How to Cite? |
Abstract | The objective is to investigate whether sedation techniques for oral surgery can be improved by combining the use of inhalation of nitrous oxide/oxygen with intravenous Midazolam. Prospective, randomized controlled clinical trial: Patients requiring extractions or surgery were randomly allocated to subgroups receiving either intravenous Midazolam or nitrous oxide/oxygen or a combined technique using nitrous oxide/oxygen and intravenous Midazolam. Safety parameters, amount of sedative agents administered, recovery time and co-operation scores were recorded. Patients receiving the combined sedation technique were initially titrated with 10% nitrous oxide, increasing by increments of 10% up to a maximum of 40% nitrous oxide and 60% oxygen. Midazolam was then titrated (initially 2 mg wait 2 min with increments of 1 mg every minute until appropriately sedated) whilst still administering 40% nitrous oxide. When a combined technique of N 2 O/O 2 and Midazolam was used there was a statistically significant reduction in the amount of Midazolam required to achieve effective sedation (P < 0.001), an overall significant reduction in recovery time (P < 0.001) and a significant improvement in co-operation (P < 0.01) and arterial oxygen saturation (P < 0.001). This combined technique was found to be safe and reliable, requiring reduced doses of Midazolam and demonstrable improvement in patient recovery and co-operation. © 2005 International Association of Oral and Maxillofacial Surgeons. |
Persistent Identifier | http://hdl.handle.net/10722/249013 |
ISSN | 2023 Impact Factor: 2.2 2023 SCImago Journal Rankings: 0.875 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Venchard, G. R. | - |
dc.contributor.author | Thomson, P. J. | - |
dc.contributor.author | Boys, R. | - |
dc.date.accessioned | 2017-10-27T05:58:52Z | - |
dc.date.available | 2017-10-27T05:58:52Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | International Journal of Oral and Maxillofacial Surgery, 2006, v. 35, n. 6, p. 522-527 | - |
dc.identifier.issn | 0901-5027 | - |
dc.identifier.uri | http://hdl.handle.net/10722/249013 | - |
dc.description.abstract | The objective is to investigate whether sedation techniques for oral surgery can be improved by combining the use of inhalation of nitrous oxide/oxygen with intravenous Midazolam. Prospective, randomized controlled clinical trial: Patients requiring extractions or surgery were randomly allocated to subgroups receiving either intravenous Midazolam or nitrous oxide/oxygen or a combined technique using nitrous oxide/oxygen and intravenous Midazolam. Safety parameters, amount of sedative agents administered, recovery time and co-operation scores were recorded. Patients receiving the combined sedation technique were initially titrated with 10% nitrous oxide, increasing by increments of 10% up to a maximum of 40% nitrous oxide and 60% oxygen. Midazolam was then titrated (initially 2 mg wait 2 min with increments of 1 mg every minute until appropriately sedated) whilst still administering 40% nitrous oxide. When a combined technique of N 2 O/O 2 and Midazolam was used there was a statistically significant reduction in the amount of Midazolam required to achieve effective sedation (P < 0.001), an overall significant reduction in recovery time (P < 0.001) and a significant improvement in co-operation (P < 0.01) and arterial oxygen saturation (P < 0.001). This combined technique was found to be safe and reliable, requiring reduced doses of Midazolam and demonstrable improvement in patient recovery and co-operation. © 2005 International Association of Oral and Maxillofacial Surgeons. | - |
dc.language | eng | - |
dc.relation.ispartof | International Journal of Oral and Maxillofacial Surgery | - |
dc.title | Improved sedation for oral surgery by combining nitrous oxide and intravenous Midazolam: a randomized, controlled trial | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.ijom.2005.11.003 | - |
dc.identifier.pmid | 16442264 | - |
dc.identifier.scopus | eid_2-s2.0-33646496590 | - |
dc.identifier.volume | 35 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 522 | - |
dc.identifier.epage | 527 | - |
dc.identifier.isi | WOS:000238103500008 | - |
dc.identifier.issnl | 0901-5027 | - |