File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1186/2045-9769-1-7
- Scopus: eid_2-s2.0-84988253836
Supplementary
-
Citations:
- Scopus: 0
- Appears in Collections:
Article: Pluripotency and its layers of complexity
Title | Pluripotency and its layers of complexity |
---|---|
Authors | |
Keywords | Naïve pluripotency Embryonic stem cells Epiblast stem cells Induced pluripotent stem cells Primed pluripotency |
Issue Date | 2012 |
Citation | Cell Regeneration, 2012, v. 1 How to Cite? |
Abstract | Pluripotency is depicted by a self-renewing state that can competently differentiate to form the three germ layers. Different stages of early murine development can be captured on a petri dish, delineating a spectrum of pluripotent states, ranging from embryonic stem cells, embryonic germ cells to epiblast stem cells. Anomalous cell populations displaying signs of pluripotency have also been uncovered, from the isolation of embryonic carcinoma cells to the derivation of induced pluripotent stem cells. Gaining insight into the molecular circuitry within these cell types enlightens us about the significance and contribution of each stage, hence deepening our understanding of vertebrate development. In this review, we aim to describe experimental milestones that led to the understanding of embryonic development and the conception of pluripotency. We also discuss attempts at exploring the realm of pluripotency with the identification of pluripotent stem cells within mouse teratocarcinomas and embryos, and the generation of pluripotent cells through nuclear reprogramming. In conclusion, we illustrate pluripotent cells derived from other organisms, including human derivatives, and describe current paradigms in the comprehension of human pluripotency. © 2012 Ooi and Liu; licensee BioMed Central Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/248985 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ooi, Jolene | - |
dc.contributor.author | Liu, Pentao | - |
dc.date.accessioned | 2017-10-27T05:58:48Z | - |
dc.date.available | 2017-10-27T05:58:48Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Cell Regeneration, 2012, v. 1 | - |
dc.identifier.uri | http://hdl.handle.net/10722/248985 | - |
dc.description.abstract | Pluripotency is depicted by a self-renewing state that can competently differentiate to form the three germ layers. Different stages of early murine development can be captured on a petri dish, delineating a spectrum of pluripotent states, ranging from embryonic stem cells, embryonic germ cells to epiblast stem cells. Anomalous cell populations displaying signs of pluripotency have also been uncovered, from the isolation of embryonic carcinoma cells to the derivation of induced pluripotent stem cells. Gaining insight into the molecular circuitry within these cell types enlightens us about the significance and contribution of each stage, hence deepening our understanding of vertebrate development. In this review, we aim to describe experimental milestones that led to the understanding of embryonic development and the conception of pluripotency. We also discuss attempts at exploring the realm of pluripotency with the identification of pluripotent stem cells within mouse teratocarcinomas and embryos, and the generation of pluripotent cells through nuclear reprogramming. In conclusion, we illustrate pluripotent cells derived from other organisms, including human derivatives, and describe current paradigms in the comprehension of human pluripotency. © 2012 Ooi and Liu; licensee BioMed Central Ltd. | - |
dc.language | eng | - |
dc.relation.ispartof | Cell Regeneration | - |
dc.subject | Naïve pluripotency | - |
dc.subject | Embryonic stem cells | - |
dc.subject | Epiblast stem cells | - |
dc.subject | Induced pluripotent stem cells | - |
dc.subject | Primed pluripotency | - |
dc.title | Pluripotency and its layers of complexity | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1186/2045-9769-1-7 | - |
dc.identifier.scopus | eid_2-s2.0-84988253836 | - |
dc.identifier.volume | 1 | - |
dc.identifier.spage | null | - |
dc.identifier.epage | null | - |
dc.identifier.eissn | 2045-9769 | - |
dc.identifier.issnl | 2045-9769 | - |