File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1158/1538-7445.AM2014-3872
- WOS: WOS:000349910201360
- Find via
Supplementary
-
Citations:
- Web of Science: 0
- Appears in Collections:
Conference Paper: Identification and characterization of ITGA7 as cancer stem cell marker in esophageal squamous cell carcinoma (ESCC)
Title | Identification and characterization of ITGA7 as cancer stem cell marker in esophageal squamous cell carcinoma (ESCC) |
---|---|
Authors | |
Issue Date | 2014 |
Publisher | American Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/ |
Citation | Proceedings of 105th American Association for Cancer Research (AACR) Annual Meeting 2014, San Diego, CA, USA, 5-9 April 2014. In Cancer Research, 2014, v. 74 n. 19, Suppl., p. Abstract no. 3872 How to Cite? |
Abstract | Cancer stem cells (CSCs) are widely accepted as a specific subpopulation of cells responsible for cancer initiation and progression. CSCs have yet to be identified in ESCC that have an increasing incidence in developed countries. Our recent study in esophageal squamous cell carcinoma (ESCC) has led to the identification of ITGA7 as a functional CSCs marker. ITGA7+ cell population is endowed with stem cell-like properties and high tumorigenic and metastatic potential. ITGA7+ CSCs isolated from ESCC cell lines possessed higher self-renewal activity and were sufficient for tumor initiation, differentiation, and metastasis compared to ITGA7- ESCC cells. Functional studies using lentiviral-based overexpression and suppression systems demonstrated that ITGA7 can promote tumor initiation and metastasis through a deregulated FAK-Raf-MEK1/2-ERK signaling pathway and epithelial-mesenchymal transition. Further characterization of ITGA7+ population may provide a prognostic biomarker for ESCC outcome prediction and a potential therapeutic target. |
Persistent Identifier | http://hdl.handle.net/10722/246159 |
ISSN | 2023 Impact Factor: 12.5 2023 SCImago Journal Rankings: 3.468 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ming, X | - |
dc.contributor.author | Fu, L | - |
dc.contributor.author | Zhang, L | - |
dc.contributor.author | Guan, X | - |
dc.date.accessioned | 2017-09-18T02:23:28Z | - |
dc.date.available | 2017-09-18T02:23:28Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Proceedings of 105th American Association for Cancer Research (AACR) Annual Meeting 2014, San Diego, CA, USA, 5-9 April 2014. In Cancer Research, 2014, v. 74 n. 19, Suppl., p. Abstract no. 3872 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | http://hdl.handle.net/10722/246159 | - |
dc.description.abstract | Cancer stem cells (CSCs) are widely accepted as a specific subpopulation of cells responsible for cancer initiation and progression. CSCs have yet to be identified in ESCC that have an increasing incidence in developed countries. Our recent study in esophageal squamous cell carcinoma (ESCC) has led to the identification of ITGA7 as a functional CSCs marker. ITGA7+ cell population is endowed with stem cell-like properties and high tumorigenic and metastatic potential. ITGA7+ CSCs isolated from ESCC cell lines possessed higher self-renewal activity and were sufficient for tumor initiation, differentiation, and metastasis compared to ITGA7- ESCC cells. Functional studies using lentiviral-based overexpression and suppression systems demonstrated that ITGA7 can promote tumor initiation and metastasis through a deregulated FAK-Raf-MEK1/2-ERK signaling pathway and epithelial-mesenchymal transition. Further characterization of ITGA7+ population may provide a prognostic biomarker for ESCC outcome prediction and a potential therapeutic target. | - |
dc.language | eng | - |
dc.publisher | American Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/ | - |
dc.relation.ispartof | Cancer Research | - |
dc.title | Identification and characterization of ITGA7 as cancer stem cell marker in esophageal squamous cell carcinoma (ESCC) | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Guan, X: xyguan@hkucc.hku.hk | - |
dc.identifier.authority | Fu, L=rp01435 | - |
dc.identifier.authority | Guan, X=rp00454 | - |
dc.identifier.doi | 10.1158/1538-7445.AM2014-3872 | - |
dc.identifier.hkuros | 276959 | - |
dc.identifier.volume | 74 | - |
dc.identifier.issue | 19, Suppl. | - |
dc.identifier.spage | Abstract no. 3872 | - |
dc.identifier.epage | Abstract no. 3872 | - |
dc.identifier.isi | WOS:000349910201360 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0008-5472 | - |