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- Publisher Website: 10.2174/1381612823666170519120040
- Scopus: eid_2-s2.0-85038004408
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Article: Pivotal roles of Interleukin-17 as the Epicenter of Bone Loss Diseases
Title | Pivotal roles of Interleukin-17 as the Epicenter of Bone Loss Diseases |
---|---|
Authors | |
Keywords | Bone loss IL-17 IL-17 receptor Osteoclastogensis Osteoclasts |
Issue Date | 2017 |
Publisher | Bentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cpd/index.htm |
Citation | Current Pharmaceutical Design, 2017, v. 23 n. 41, p. 6302-6309 How to Cite? |
Abstract | Bone remodelling is a strictly regulated dynamic process between bone resorption and bone formation. Many factors are involved in the process and affect the dynamic balance. Inflammation-mediated bone loss is a major feature of various bone diseases, including periodontitis, rheumatoid arthritis (RA) and spondyloarthritis (SpA). Interleukin-17 (IL-17) plays an important role in inflammatory bone disease and could be an attractive therapeutic target. This review focuses on the osteoclastic effects of IL-17 in different cell types and summarizes the current knowledge of IL-17 signalling pathways. Typical IL-17–mediated bone destruction disorders are examined. The review also provides an overview of possible strategies for therapeutic intervention for inflammatory. © 2017 Bentham Science Publishers. |
Persistent Identifier | http://hdl.handle.net/10722/244799 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 0.586 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Liao, C | - |
dc.contributor.author | Zhang, C | - |
dc.contributor.author | Yang, Y | - |
dc.date.accessioned | 2017-09-18T01:59:16Z | - |
dc.date.available | 2017-09-18T01:59:16Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Current Pharmaceutical Design, 2017, v. 23 n. 41, p. 6302-6309 | - |
dc.identifier.issn | 1381-6128 | - |
dc.identifier.uri | http://hdl.handle.net/10722/244799 | - |
dc.description.abstract | Bone remodelling is a strictly regulated dynamic process between bone resorption and bone formation. Many factors are involved in the process and affect the dynamic balance. Inflammation-mediated bone loss is a major feature of various bone diseases, including periodontitis, rheumatoid arthritis (RA) and spondyloarthritis (SpA). Interleukin-17 (IL-17) plays an important role in inflammatory bone disease and could be an attractive therapeutic target. This review focuses on the osteoclastic effects of IL-17 in different cell types and summarizes the current knowledge of IL-17 signalling pathways. Typical IL-17–mediated bone destruction disorders are examined. The review also provides an overview of possible strategies for therapeutic intervention for inflammatory. © 2017 Bentham Science Publishers. | - |
dc.language | eng | - |
dc.publisher | Bentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cpd/index.htm | - |
dc.relation.ispartof | Current Pharmaceutical Design | - |
dc.subject | Bone loss | - |
dc.subject | IL-17 | - |
dc.subject | IL-17 receptor | - |
dc.subject | Osteoclastogensis | - |
dc.subject | Osteoclasts | - |
dc.title | Pivotal roles of Interleukin-17 as the Epicenter of Bone Loss Diseases | - |
dc.type | Article | - |
dc.identifier.email | Zhang, C: zhangcf@hku.hk | - |
dc.identifier.email | Yang, Y: yangyanq@hku.hk | - |
dc.identifier.authority | Zhang, C=rp01408 | - |
dc.identifier.authority | Yang, Y=rp00045 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.2174/1381612823666170519120040 | - |
dc.identifier.scopus | eid_2-s2.0-85038004408 | - |
dc.identifier.hkuros | 279299 | - |
dc.identifier.volume | 23 | - |
dc.identifier.issue | 41 | - |
dc.identifier.spage | 6302 | - |
dc.identifier.epage | 6309 | - |
dc.identifier.isi | WOS:000425351700010 | - |
dc.publisher.place | Netherlands | - |
dc.identifier.issnl | 1381-6128 | - |