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Article: Cellular Interactions and Formation of an Epithelial “Nanocoating-Like Barrier” with Mesoporous Silica Nanoparticles

TitleCellular Interactions and Formation of an Epithelial “Nanocoating-Like Barrier” with Mesoporous Silica Nanoparticles
Authors
KeywordsNanoparticles
Human gingival epithelium
Coating
Stratum corneum
Issue Date2016
PublisherMDPIAG. The Journal's web site is located at http://www.mdpi.com/journal/nanomaterials
Citation
Nanomaterials, 2016, v. 6, p. 192 How to Cite?
AbstractOral mucosa as the front-line barrier in the mouth is constantly exposed to a complex microenvironment with multitudinous microbes. In this study, the interactions of mesoporous silica nanoparticles (MSNs) with primary human gingival epithelial cells were analyzed for up to 72 h, and their diffusion capacity in the reconstructed human gingival epithelia (RHGE) and porcine ear skin models was further assessed at 24 h. It was found that the synthesized fluorescent mesoporous silica nanoparticles (RITC-NPs) with low cytotoxicity could be uptaken, degraded, and/or excreted by the human gingival epithelial cells. Moreover, the RITC-NPs penetrated into the stratum corneum of RHGE in a time-dependent manner, while they were unable to get across the barrier of stratum corneum in the porcine ear skins. Consequently, the penetration and accumulation of RITC-NPs at the corneum layers of epithelia could form a “nanocoating-like barrier”. This preliminary proof-of-concept study suggests the feasibility of developing nanoparticle-based antimicrobial and anti-inflammatory agents through topical application for oral healthcare.
Persistent Identifierhttp://hdl.handle.net/10722/244794
ISSN
2018 Impact Factor: 4.034
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLI, X-
dc.contributor.authorPang, KY-
dc.contributor.authorNg, TW-
dc.contributor.authorLeung, PC-
dc.contributor.authorZhang, C-
dc.contributor.authorLeung, KCF-
dc.contributor.authorJin, L-
dc.date.accessioned2017-09-18T01:59:11Z-
dc.date.available2017-09-18T01:59:11Z-
dc.date.issued2016-
dc.identifier.citationNanomaterials, 2016, v. 6, p. 192-
dc.identifier.issn2079-4991-
dc.identifier.urihttp://hdl.handle.net/10722/244794-
dc.description.abstractOral mucosa as the front-line barrier in the mouth is constantly exposed to a complex microenvironment with multitudinous microbes. In this study, the interactions of mesoporous silica nanoparticles (MSNs) with primary human gingival epithelial cells were analyzed for up to 72 h, and their diffusion capacity in the reconstructed human gingival epithelia (RHGE) and porcine ear skin models was further assessed at 24 h. It was found that the synthesized fluorescent mesoporous silica nanoparticles (RITC-NPs) with low cytotoxicity could be uptaken, degraded, and/or excreted by the human gingival epithelial cells. Moreover, the RITC-NPs penetrated into the stratum corneum of RHGE in a time-dependent manner, while they were unable to get across the barrier of stratum corneum in the porcine ear skins. Consequently, the penetration and accumulation of RITC-NPs at the corneum layers of epithelia could form a “nanocoating-like barrier”. This preliminary proof-of-concept study suggests the feasibility of developing nanoparticle-based antimicrobial and anti-inflammatory agents through topical application for oral healthcare.-
dc.languageeng-
dc.publisherMDPIAG. The Journal's web site is located at http://www.mdpi.com/journal/nanomaterials-
dc.relation.ispartofNanomaterials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectNanoparticles-
dc.subjectHuman gingival epithelium-
dc.subjectCoating-
dc.subjectStratum corneum-
dc.titleCellular Interactions and Formation of an Epithelial “Nanocoating-Like Barrier” with Mesoporous Silica Nanoparticles-
dc.typeArticle-
dc.identifier.emailZhang, C: zhangcf@hku.hk-
dc.identifier.emailJin, L: ljjin@hkucc.hku.hk-
dc.identifier.authorityZhang, C=rp01408-
dc.identifier.authorityJin, L=rp00028-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/nano6110192-
dc.identifier.scopuseid_2-s2.0-84998854212-
dc.identifier.hkuros278097-
dc.identifier.volume6-
dc.identifier.spage192-
dc.identifier.epage192-
dc.identifier.isiWOS:000390103400002-
dc.publisher.placeSwitzerland-
dc.identifier.issnl2079-4991-

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