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Article: Amygdala volume and hypothalamic-pituitary-adrenal axis reactivity to social stress

TitleAmygdala volume and hypothalamic-pituitary-adrenal axis reactivity to social stress
Authors
KeywordsAmygdala
Cortisol
Depression
Hypothalamic-pituitary-adrenal axis
Stress sensitivity
Issue Date2017
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/psyneuen
Citation
Psychoneuroendocrinology, 2017, v. 85, p. 96-99 How to Cite?
AbstractThe amygdala plays a central role in emotional processing and has an activating influence on the hypothalamic-pituitary-adrenal (HPA) axis. Structural changes in the amygdala have been associated with early adversity and, in principle, may contribute to the later emergence of emotional pathologies by influencing the way that the brain responds to stress provocation. The present study examined the relationship between amygdala volumes and cortisol secretion in response to a social stressor among young adults who were or were not exposed to maternal postnatal depression (PND) early in development (referred to as PND offspring and controls, respectively). Hierarchical Linear Modelling (HLM) revealed that, on a sample-wide level, there was no evidence of a relationship between total amygdala volume, or the volume of the right or left hemisphere amygdala taken separately, and cortisol reactivity. Unexpectedly, for PND offspring, larger right hemisphere amygdala volume was associated with lower cortisol reactivity in response to stress, an effect that was not apparent in control offspring. We conclude that the relationship between amygdala volumes and stress reactivity may not be as clear as previous models suggested.
Persistent Identifierhttp://hdl.handle.net/10722/244346
ISSN
2023 Impact Factor: 3.4
2023 SCImago Journal Rankings: 1.373
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBarry, TJ-
dc.contributor.authorMurray, L-
dc.contributor.authorFearon, P-
dc.contributor.authorMoutsiana, C-
dc.contributor.authorJohnstone, T-
dc.contributor.authorHalligan, SL-
dc.date.accessioned2017-09-15T07:03:38Z-
dc.date.available2017-09-15T07:03:38Z-
dc.date.issued2017-
dc.identifier.citationPsychoneuroendocrinology, 2017, v. 85, p. 96-99-
dc.identifier.issn0306-4530-
dc.identifier.urihttp://hdl.handle.net/10722/244346-
dc.description.abstractThe amygdala plays a central role in emotional processing and has an activating influence on the hypothalamic-pituitary-adrenal (HPA) axis. Structural changes in the amygdala have been associated with early adversity and, in principle, may contribute to the later emergence of emotional pathologies by influencing the way that the brain responds to stress provocation. The present study examined the relationship between amygdala volumes and cortisol secretion in response to a social stressor among young adults who were or were not exposed to maternal postnatal depression (PND) early in development (referred to as PND offspring and controls, respectively). Hierarchical Linear Modelling (HLM) revealed that, on a sample-wide level, there was no evidence of a relationship between total amygdala volume, or the volume of the right or left hemisphere amygdala taken separately, and cortisol reactivity. Unexpectedly, for PND offspring, larger right hemisphere amygdala volume was associated with lower cortisol reactivity in response to stress, an effect that was not apparent in control offspring. We conclude that the relationship between amygdala volumes and stress reactivity may not be as clear as previous models suggested.-
dc.languageeng-
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/psyneuen-
dc.relation.ispartofPsychoneuroendocrinology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAmygdala-
dc.subjectCortisol-
dc.subjectDepression-
dc.subjectHypothalamic-pituitary-adrenal axis-
dc.subjectStress sensitivity-
dc.titleAmygdala volume and hypothalamic-pituitary-adrenal axis reactivity to social stress-
dc.typeArticle-
dc.identifier.emailBarry, TJ: tjbarry@hku.hk-
dc.identifier.authorityBarry, TJ=rp02277-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.psyneuen.2017.07.487-
dc.identifier.scopuseid_2-s2.0-85028002352-
dc.identifier.hkuros279211-
dc.identifier.volume85-
dc.identifier.spage96-
dc.identifier.epage99-
dc.identifier.isiWOS:000413384900014-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0306-4530-

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