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Article: Role of free fatty acids in endothelial dysfunction

TitleRole of free fatty acids in endothelial dysfunction
Authors
KeywordsOxidative stress
Free fatty acids
Endothelial dysfunction
Inflammation
Insulin resistance
Nitric oxide
Issue Date2017
Citation
Journal of Biomedical Science, 2017, v. 24, n. 1 How to Cite?
Abstract© 2017 The Author(s). Plasma free fatty acids levels are increased in subjects with obesity and type 2 diabetes, playing detrimental roles in the pathogenesis of atherosclerosis and cardiovascular diseases. Increasing evidence showing that dysfunction of the vascular endothelium, the inner lining of the blood vessels, is the key player in the pathogenesis of atherosclerosis. In this review, we aimed to summarize the roles and the underlying mechanisms using the evidence collected from clinical and experimental studies about free fatty acid-mediated endothelial dysfunction. Because of the multifaceted roles of plasma free fatty acids in mediating endothelial dysfunction, elevated free fatty acid level is now considered as an important link in the onset of endothelial dysfunction due to metabolic syndromes such as diabetes and obesity. Free fatty acid-mediated endothelial dysfunction involves several mechanisms including impaired insulin signaling and nitric oxide production, oxidative stress, inflammation and the activation of the renin-angiotensin system and apoptosis in the endothelial cells. Therefore, targeting the signaling pathways involved in free fatty acid-induced endothelial dysfunction could serve as a preventive approach to protect against the occurrence of endothelial dysfunction and the subsequent complications such as atherosclerosis.
Persistent Identifierhttp://hdl.handle.net/10722/244255
ISSN
2023 Impact Factor: 9.0
2023 SCImago Journal Rankings: 2.606
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGhosh, Arijit-
dc.contributor.authorGao, Lei-
dc.contributor.authorThakur, Abhimanyu-
dc.contributor.authorSiu, Parco M.-
dc.contributor.authorLai, Christopher W.K.-
dc.date.accessioned2017-08-31T08:56:29Z-
dc.date.available2017-08-31T08:56:29Z-
dc.date.issued2017-
dc.identifier.citationJournal of Biomedical Science, 2017, v. 24, n. 1-
dc.identifier.issn1021-7770-
dc.identifier.urihttp://hdl.handle.net/10722/244255-
dc.description.abstract© 2017 The Author(s). Plasma free fatty acids levels are increased in subjects with obesity and type 2 diabetes, playing detrimental roles in the pathogenesis of atherosclerosis and cardiovascular diseases. Increasing evidence showing that dysfunction of the vascular endothelium, the inner lining of the blood vessels, is the key player in the pathogenesis of atherosclerosis. In this review, we aimed to summarize the roles and the underlying mechanisms using the evidence collected from clinical and experimental studies about free fatty acid-mediated endothelial dysfunction. Because of the multifaceted roles of plasma free fatty acids in mediating endothelial dysfunction, elevated free fatty acid level is now considered as an important link in the onset of endothelial dysfunction due to metabolic syndromes such as diabetes and obesity. Free fatty acid-mediated endothelial dysfunction involves several mechanisms including impaired insulin signaling and nitric oxide production, oxidative stress, inflammation and the activation of the renin-angiotensin system and apoptosis in the endothelial cells. Therefore, targeting the signaling pathways involved in free fatty acid-induced endothelial dysfunction could serve as a preventive approach to protect against the occurrence of endothelial dysfunction and the subsequent complications such as atherosclerosis.-
dc.languageeng-
dc.relation.ispartofJournal of Biomedical Science-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectOxidative stress-
dc.subjectFree fatty acids-
dc.subjectEndothelial dysfunction-
dc.subjectInflammation-
dc.subjectInsulin resistance-
dc.subjectNitric oxide-
dc.titleRole of free fatty acids in endothelial dysfunction-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s12929-017-0357-5-
dc.identifier.scopuseid_2-s2.0-85026270192-
dc.identifier.volume24-
dc.identifier.issue1-
dc.identifier.spagenull-
dc.identifier.epagenull-
dc.identifier.eissn1423-0127-
dc.identifier.isiWOS:000406698500001-
dc.identifier.issnl1021-7770-

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