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Article: Nuclear apoptosis contributes to sarcopenia

TitleNuclear apoptosis contributes to sarcopenia
Authors
Alway, Stephen E.Siu, Parco M.
KeywordsMitochondria
Satellite cells
Signaling proteins
Skeletal myofiber
Atrophy
Issue Date2008
Citation
Exercise and Sport Sciences Reviews, 2008, v. 36, n. 2, p. 51-57 How to Cite?
DOI: http://dx.doi.org/10.1097/JES.0b013e318168e9dc
AbstractApoptosis results in DNA fragmentation and, subsequently, destruction of cells containing a single nucleus. Our hypothesis is that multinucleated cells such as muscle fibers can experience apoptotic-induced loss of single nuclei (nuclear apoptosis) without destruction of the entire fiber. The loss of nuclei likely contributes to atrophy and sarcopenia. Furthermore, increased chronic activity attenuates apoptotic signaling, which may reduce sarcopenia. ©2008The Amercian College of Sports Medicine.
Persistent Identifierhttp://hdl.handle.net/10722/244088
ISSN
0091-6331
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.688
ISI Accession Number ID
WOS:000254477700002

 

DC FieldValueLanguage
dc.contributor.authorAlway, Stephen E.-
dc.contributor.authorSiu, Parco M.-
dc.date.accessioned2017-08-31T08:56:01Z-
dc.date.available2017-08-31T08:56:01Z-
dc.date.issued2008-
dc.identifier.citationExercise and Sport Sciences Reviews, 2008, v. 36, n. 2, p. 51-57-
dc.identifier.issn0091-6331-
dc.identifier.urihttp://hdl.handle.net/10722/244088-
dc.description.abstractApoptosis results in DNA fragmentation and, subsequently, destruction of cells containing a single nucleus. Our hypothesis is that multinucleated cells such as muscle fibers can experience apoptotic-induced loss of single nuclei (nuclear apoptosis) without destruction of the entire fiber. The loss of nuclei likely contributes to atrophy and sarcopenia. Furthermore, increased chronic activity attenuates apoptotic signaling, which may reduce sarcopenia. ©2008The Amercian College of Sports Medicine.-
dc.languageeng-
dc.relation.ispartofExercise and Sport Sciences Reviews-
dc.subjectMitochondria-
dc.subjectSatellite cells-
dc.subjectSignaling proteins-
dc.subjectSkeletal myofiber-
dc.subjectAtrophy-
dc.titleNuclear apoptosis contributes to sarcopenia-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/JES.0b013e318168e9dc-
dc.identifier.pmid18362685-
dc.identifier.scopuseid_2-s2.0-41149139501-
dc.identifier.volume36-
dc.identifier.issue2-
dc.identifier.spage51-
dc.identifier.epage57-
dc.identifier.isiWOS:000254477700002-
dc.identifier.issnl0091-6331-

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