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- Publisher Website: 10.1016/j.exger.2005.11.004
- Scopus: eid_2-s2.0-31544434882
- PMID: 16377111
- WOS: WOS:000235423900009
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Article: Aging alters the reduction of pro-apoptotic signaling in response to loading-induced hypertrophy
Title | Aging alters the reduction of pro-apoptotic signaling in response to loading-induced hypertrophy |
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Authors | |
Keywords | Aging Muscle hypertrophy XIAP Apoptosis AIF Repressors to apoptosis Sarcopenia |
Issue Date | 2006 |
Citation | Experimental Gerontology, 2006, v. 41, n. 2, p. 175-188 How to Cite? |
Abstract | This study tested the hypothesis that loading decreased apoptosis in skeletal muscle in an aging-dependent fashion. One wing of young and aged Japanese quails was loaded for 7 or 21 days to induce hypertrophy. The contralateral wing served as the intra-animal control. Loading increased fast-twitch quail patagialis muscle mass by 28 and 49%, after 7 or 21 days of loading, respectively in young adult birds. Muscle mass was not elevated after 7 days of loading, but increased by 29% after 21 days of loading in aged birds. Seven days of loading reduced DNA fragmentation and cytosolic accumulation of cytochrome c in muscles from young birds but not in muscles from aged birds. ARC protein content was lower and H 2 O 2 content was higher in muscles from aged birds following 7 days of loading. The mitochondria-free cytosolic protein fraction from muscles loaded for 7 days had 41 and 29% lower AIF content than control muscles in young and aged birds, respectively. XIAP, an apoptotic suppressor protein increased after 7 days of loading in muscles from young adult but not aged birds. Our results suggest that loading suppresses pro-apoptotic signaling in quail muscle but aging delays or attenuates these anti-apoptotic changes. © 2005 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/244079 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 1.051 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Siu, Parco M. | - |
dc.contributor.author | Alway, Stephen E. | - |
dc.date.accessioned | 2017-08-31T08:55:59Z | - |
dc.date.available | 2017-08-31T08:55:59Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Experimental Gerontology, 2006, v. 41, n. 2, p. 175-188 | - |
dc.identifier.issn | 0531-5565 | - |
dc.identifier.uri | http://hdl.handle.net/10722/244079 | - |
dc.description.abstract | This study tested the hypothesis that loading decreased apoptosis in skeletal muscle in an aging-dependent fashion. One wing of young and aged Japanese quails was loaded for 7 or 21 days to induce hypertrophy. The contralateral wing served as the intra-animal control. Loading increased fast-twitch quail patagialis muscle mass by 28 and 49%, after 7 or 21 days of loading, respectively in young adult birds. Muscle mass was not elevated after 7 days of loading, but increased by 29% after 21 days of loading in aged birds. Seven days of loading reduced DNA fragmentation and cytosolic accumulation of cytochrome c in muscles from young birds but not in muscles from aged birds. ARC protein content was lower and H 2 O 2 content was higher in muscles from aged birds following 7 days of loading. The mitochondria-free cytosolic protein fraction from muscles loaded for 7 days had 41 and 29% lower AIF content than control muscles in young and aged birds, respectively. XIAP, an apoptotic suppressor protein increased after 7 days of loading in muscles from young adult but not aged birds. Our results suggest that loading suppresses pro-apoptotic signaling in quail muscle but aging delays or attenuates these anti-apoptotic changes. © 2005 Elsevier Inc. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Experimental Gerontology | - |
dc.subject | Aging | - |
dc.subject | Muscle hypertrophy | - |
dc.subject | XIAP | - |
dc.subject | Apoptosis | - |
dc.subject | AIF | - |
dc.subject | Repressors to apoptosis | - |
dc.subject | Sarcopenia | - |
dc.title | Aging alters the reduction of pro-apoptotic signaling in response to loading-induced hypertrophy | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.exger.2005.11.004 | - |
dc.identifier.pmid | 16377111 | - |
dc.identifier.scopus | eid_2-s2.0-31544434882 | - |
dc.identifier.volume | 41 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 175 | - |
dc.identifier.epage | 188 | - |
dc.identifier.isi | WOS:000235423900009 | - |
dc.identifier.issnl | 0531-5565 | - |