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Article: MERS-CoV antibody responses 1 Year after symptom onset, South Korea, 2015

TitleMERS-CoV antibody responses 1 Year after symptom onset, South Korea, 2015
Authors
Issue Date2017
PublisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm
Citation
Emerging Infectious Diseases, 2017, v. 23 n. 7, p. 1079-1084 How to Cite?
AbstractWe investigated the kinetics of the Middle East respiratory syndrome coronavirus (MERS-CoV) neutralizing and spike protein antibody titers over the course of 1 year in 11 patients who were confirmed by reverse transcription PCR to have been infected during the outbreak in South Korea in 2015. Robust antibody responses were detected in all survivors who had severe disease; responses remained detectable, albeit with some waning, for <1 year. The duration of viral RNA detection (but not viral load) in sputum significantly correlated with the antibody response magnitude. The MERS S1 ELISA antibody titers correlated well with the neutralizing antibody response. Antibody titers in 4 of 6 patients who had mild illness were undetectable even though most had evidence of pneumonia. This finding implies that MERS-CoV seroepidemiologic studies markedly underestimate the extent of mild and asymptomatic infection. Obtaining convalescent-phase plasma with high antibody titers to treat MERS will be challenging.
Persistent Identifierhttp://hdl.handle.net/10722/242869
ISSN
2019 Impact Factor: 6.259
2015 SCImago Journal Rankings: 3.023
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChoe, PG-
dc.contributor.authorPerera, RAPM-
dc.contributor.authorPark, WB-
dc.contributor.authorSong, KH-
dc.contributor.authorBang, JH-
dc.contributor.authorKim, ES-
dc.contributor.authorKim, HB-
dc.contributor.authorKo, LWR-
dc.contributor.authorPark, SW-
dc.contributor.authorKim, NJ-
dc.contributor.authorLau, EHY-
dc.contributor.authorPoon, LML-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorOh, MD-
dc.date.accessioned2017-08-25T02:46:32Z-
dc.date.available2017-08-25T02:46:32Z-
dc.date.issued2017-
dc.identifier.citationEmerging Infectious Diseases, 2017, v. 23 n. 7, p. 1079-1084-
dc.identifier.issn1080-6040-
dc.identifier.urihttp://hdl.handle.net/10722/242869-
dc.description.abstractWe investigated the kinetics of the Middle East respiratory syndrome coronavirus (MERS-CoV) neutralizing and spike protein antibody titers over the course of 1 year in 11 patients who were confirmed by reverse transcription PCR to have been infected during the outbreak in South Korea in 2015. Robust antibody responses were detected in all survivors who had severe disease; responses remained detectable, albeit with some waning, for <1 year. The duration of viral RNA detection (but not viral load) in sputum significantly correlated with the antibody response magnitude. The MERS S1 ELISA antibody titers correlated well with the neutralizing antibody response. Antibody titers in 4 of 6 patients who had mild illness were undetectable even though most had evidence of pneumonia. This finding implies that MERS-CoV seroepidemiologic studies markedly underestimate the extent of mild and asymptomatic infection. Obtaining convalescent-phase plasma with high antibody titers to treat MERS will be challenging.-
dc.languageeng-
dc.publisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm-
dc.relation.ispartofEmerging Infectious Diseases-
dc.titleMERS-CoV antibody responses 1 Year after symptom onset, South Korea, 2015-
dc.typeArticle-
dc.identifier.emailPerera, RAPM: mahenp@hku.hk-
dc.identifier.emailKo, LWR: koronald@hku.hk-
dc.identifier.emailLau, EHY: ehylau@hku.hk-
dc.identifier.emailPoon, LML: llmpoon@hkucc.hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.authorityLau, EHY=rp01349-
dc.identifier.authorityPoon, LML=rp00484-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.3201/eid2307.170310-
dc.identifier.pmid28585916-
dc.identifier.scopuseid_2-s2.0-85021110525-
dc.identifier.hkuros274161-
dc.identifier.volume23-
dc.identifier.issue7-
dc.identifier.spage1079-
dc.identifier.epage1084-
dc.identifier.isiWOS:000403563100004-
dc.publisher.placeUnited States-
dc.identifier.issnl1080-6040-

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