File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Excessive Daytime Sleepiness Predicts Neurodegeneration in Idiopathic REM Sleep Behavior Disorder

TitleExcessive Daytime Sleepiness Predicts Neurodegeneration in Idiopathic REM Sleep Behavior Disorder
Authors
Issue Date2017
PublisherThe American Academy of Sleep Medicine. The Journal's web site is located at http://www.journalsleep.org
Citation
Sleep, 2017, v. 40 n. 5, p. zsx041 How to Cite?
AbstractSTUDY OBJECTIVES: To determine the association of excessive daytime sleepiness (EDS) with the conversion of neurodegenerative diseases in patients with idiopathic REM sleep behavior disorder (iRBD). METHODS: A total of 179 patients with iRBD (79.1% males, mean age = 66.3 ± 9.8 years) were consecutively recruited. Forty-five patients with Epworth Sleepiness Scale score ≥14 were defined as having EDS. Demographic, clinical, and polysomnographic data were compared between iRBD patients with and without EDS. The risk of developing neurodegenerative diseases was examined using Cox proportional hazards model. RESULTS: After a mean follow-up of 5.8 years (SD = 4.3 years), 50 (27.9%) patients developed neurodegenerative diseases. There was a significantly higher proportion of conversion in patients with EDS compared to those without EDS (42.2 % vs. 23.1%, p = .01). EDS significantly predicted an increased risk of developing neurodegenerative diseases (adjusted hazard ratios [HR] = 2.56, 95% confidence interval [CI] 1.37 to 4.77) after adjusting for age, sex, body mass index, current depression, obstructive sleep apnea, and periodic limb movements during sleep. Further analyses demonstrated that EDS predicted the conversion of Parkinson's disease (PD) (adjusted HR = 3.55, 95% CI 1.59 to 7.89) but not dementia (adjusted HR = 1.48, 95% CI 0.44 to 4.97). CONCLUSIONS: EDS is associated with an increased risk of developing neurodegenerative diseases, especially PD, in patients with iRBD. Our findings suggest that EDS is a potential clinical biomarker of α-synucleinopathies in iRBD.
Persistent Identifierhttp://hdl.handle.net/10722/241535
ISSN
2019 Impact Factor: 4.805
2015 SCImago Journal Rankings: 2.606
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, J-
dc.contributor.authorZhang, J-
dc.contributor.authorLam, SP-
dc.contributor.authorChan, JWY-
dc.contributor.authorMok, V-
dc.contributor.authorChan, APS-
dc.contributor.authorLi, XS-
dc.contributor.authorLiu, Y-
dc.contributor.authorTang, X-
dc.contributor.authorYung, WH-
dc.contributor.authorWing, YK-
dc.date.accessioned2017-06-20T01:45:03Z-
dc.date.available2017-06-20T01:45:03Z-
dc.date.issued2017-
dc.identifier.citationSleep, 2017, v. 40 n. 5, p. zsx041-
dc.identifier.issn0161-8105-
dc.identifier.urihttp://hdl.handle.net/10722/241535-
dc.description.abstractSTUDY OBJECTIVES: To determine the association of excessive daytime sleepiness (EDS) with the conversion of neurodegenerative diseases in patients with idiopathic REM sleep behavior disorder (iRBD). METHODS: A total of 179 patients with iRBD (79.1% males, mean age = 66.3 ± 9.8 years) were consecutively recruited. Forty-five patients with Epworth Sleepiness Scale score ≥14 were defined as having EDS. Demographic, clinical, and polysomnographic data were compared between iRBD patients with and without EDS. The risk of developing neurodegenerative diseases was examined using Cox proportional hazards model. RESULTS: After a mean follow-up of 5.8 years (SD = 4.3 years), 50 (27.9%) patients developed neurodegenerative diseases. There was a significantly higher proportion of conversion in patients with EDS compared to those without EDS (42.2 % vs. 23.1%, p = .01). EDS significantly predicted an increased risk of developing neurodegenerative diseases (adjusted hazard ratios [HR] = 2.56, 95% confidence interval [CI] 1.37 to 4.77) after adjusting for age, sex, body mass index, current depression, obstructive sleep apnea, and periodic limb movements during sleep. Further analyses demonstrated that EDS predicted the conversion of Parkinson's disease (PD) (adjusted HR = 3.55, 95% CI 1.59 to 7.89) but not dementia (adjusted HR = 1.48, 95% CI 0.44 to 4.97). CONCLUSIONS: EDS is associated with an increased risk of developing neurodegenerative diseases, especially PD, in patients with iRBD. Our findings suggest that EDS is a potential clinical biomarker of α-synucleinopathies in iRBD.-
dc.languageeng-
dc.publisherThe American Academy of Sleep Medicine. The Journal's web site is located at http://www.journalsleep.org-
dc.relation.ispartofSleep-
dc.titleExcessive Daytime Sleepiness Predicts Neurodegeneration in Idiopathic REM Sleep Behavior Disorder-
dc.typeArticle-
dc.identifier.emailLi, XS: shirleyx@hku.hk-
dc.identifier.authorityLi, XS=rp02114-
dc.identifier.doi10.1093/sleep/zsx041-
dc.identifier.hkuros272427-
dc.identifier.volume40-
dc.identifier.issue5-
dc.identifier.spagezsx041-
dc.identifier.epagezsx041-
dc.identifier.isiWOS:000401699100004-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats