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- Publisher Website: 10.1093/sleep/zsx041
- Scopus: eid_2-s2.0-85018950558
- WOS: WOS:000401699100004
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Article: Excessive Daytime Sleepiness Predicts Neurodegeneration in Idiopathic REM Sleep Behavior Disorder
Title | Excessive Daytime Sleepiness Predicts Neurodegeneration in Idiopathic REM Sleep Behavior Disorder |
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Authors | |
Keywords | Dementia Excessive daytime sleepiness Neurodegenerative disease Parkinson's disease REM sleep behavior disorder |
Issue Date | 2017 |
Publisher | The American Academy of Sleep Medicine. The Journal's web site is located at http://www.journalsleep.org |
Citation | Sleep, 2017, v. 40 n. 5, p. zsx041 How to Cite? |
Abstract | STUDY OBJECTIVES: To determine the association of excessive daytime sleepiness (EDS) with the conversion of neurodegenerative diseases in patients with idiopathic REM sleep behavior disorder (iRBD). METHODS: A total of 179 patients with iRBD (79.1% males, mean age = 66.3 ± 9.8 years) were consecutively recruited. Forty-five patients with Epworth Sleepiness Scale score ≥14 were defined as having EDS. Demographic, clinical, and polysomnographic data were compared between iRBD patients with and without EDS. The risk of developing neurodegenerative diseases was examined using Cox proportional hazards model. RESULTS: After a mean follow-up of 5.8 years (SD = 4.3 years), 50 (27.9%) patients developed neurodegenerative diseases. There was a significantly higher proportion of conversion in patients with EDS compared to those without EDS (42.2 % vs. 23.1%, p = .01). EDS significantly predicted an increased risk of developing neurodegenerative diseases (adjusted hazard ratios [HR] = 2.56, 95% confidence interval [CI] 1.37 to 4.77) after adjusting for age, sex, body mass index, current depression, obstructive sleep apnea, and periodic limb movements during sleep. Further analyses demonstrated that EDS predicted the conversion of Parkinson's disease (PD) (adjusted HR = 3.55, 95% CI 1.59 to 7.89) but not dementia (adjusted HR = 1.48, 95% CI 0.44 to 4.97). CONCLUSIONS: EDS is associated with an increased risk of developing neurodegenerative diseases, especially PD, in patients with iRBD. Our findings suggest that EDS is a potential clinical biomarker of α-synucleinopathies in iRBD. |
Persistent Identifier | http://hdl.handle.net/10722/241535 |
ISSN | 2023 Impact Factor: 5.3 2023 SCImago Journal Rankings: 1.717 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhou, J | - |
dc.contributor.author | Zhang, J | - |
dc.contributor.author | Lam, SP | - |
dc.contributor.author | Chan, JWY | - |
dc.contributor.author | Mok, V | - |
dc.contributor.author | Chan, APS | - |
dc.contributor.author | Li, XS | - |
dc.contributor.author | Liu, Y | - |
dc.contributor.author | Tang, X | - |
dc.contributor.author | Yung, WH | - |
dc.contributor.author | Wing, YK | - |
dc.date.accessioned | 2017-06-20T01:45:03Z | - |
dc.date.available | 2017-06-20T01:45:03Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Sleep, 2017, v. 40 n. 5, p. zsx041 | - |
dc.identifier.issn | 0161-8105 | - |
dc.identifier.uri | http://hdl.handle.net/10722/241535 | - |
dc.description.abstract | STUDY OBJECTIVES: To determine the association of excessive daytime sleepiness (EDS) with the conversion of neurodegenerative diseases in patients with idiopathic REM sleep behavior disorder (iRBD). METHODS: A total of 179 patients with iRBD (79.1% males, mean age = 66.3 ± 9.8 years) were consecutively recruited. Forty-five patients with Epworth Sleepiness Scale score ≥14 were defined as having EDS. Demographic, clinical, and polysomnographic data were compared between iRBD patients with and without EDS. The risk of developing neurodegenerative diseases was examined using Cox proportional hazards model. RESULTS: After a mean follow-up of 5.8 years (SD = 4.3 years), 50 (27.9%) patients developed neurodegenerative diseases. There was a significantly higher proportion of conversion in patients with EDS compared to those without EDS (42.2 % vs. 23.1%, p = .01). EDS significantly predicted an increased risk of developing neurodegenerative diseases (adjusted hazard ratios [HR] = 2.56, 95% confidence interval [CI] 1.37 to 4.77) after adjusting for age, sex, body mass index, current depression, obstructive sleep apnea, and periodic limb movements during sleep. Further analyses demonstrated that EDS predicted the conversion of Parkinson's disease (PD) (adjusted HR = 3.55, 95% CI 1.59 to 7.89) but not dementia (adjusted HR = 1.48, 95% CI 0.44 to 4.97). CONCLUSIONS: EDS is associated with an increased risk of developing neurodegenerative diseases, especially PD, in patients with iRBD. Our findings suggest that EDS is a potential clinical biomarker of α-synucleinopathies in iRBD. | - |
dc.language | eng | - |
dc.publisher | The American Academy of Sleep Medicine. The Journal's web site is located at http://www.journalsleep.org | - |
dc.relation.ispartof | Sleep | - |
dc.subject | Dementia | - |
dc.subject | Excessive daytime sleepiness | - |
dc.subject | Neurodegenerative disease | - |
dc.subject | Parkinson's disease | - |
dc.subject | REM sleep behavior disorder | - |
dc.title | Excessive Daytime Sleepiness Predicts Neurodegeneration in Idiopathic REM Sleep Behavior Disorder | - |
dc.type | Article | - |
dc.identifier.email | Li, XS: shirleyx@hku.hk | - |
dc.identifier.authority | Li, XS=rp02114 | - |
dc.identifier.doi | 10.1093/sleep/zsx041 | - |
dc.identifier.scopus | eid_2-s2.0-85018950558 | - |
dc.identifier.hkuros | 272427 | - |
dc.identifier.volume | 40 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | zsx041 | - |
dc.identifier.epage | zsx041 | - |
dc.identifier.isi | WOS:000401699100004 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0161-8105 | - |