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Article: Systematic identification of immunodominant CD8+ T-cell responses to influenza A virus in HLA-A2 individuals

TitleSystematic identification of immunodominant CD8<sup>+</sup> T-cell responses to influenza A virus in HLA-A2 individuals
Authors
Issue Date2011
Citation
Proceedings of the National Academy of Sciences of the United States of America, 2011, v. 108, n. 22, p. 9178-9183 How to Cite?
AbstractImmunodominant T-cell responses are important for virus clearance. However, the identification of immunodominant T-cell peptide + HLA glycoprotein epitopes has been hindered by the extent of HLA polymorphism and the limitations of predictive algorithms. A simple, systematic approach has been used here to screen for immunodominant CD8+ T-cell specificities. The analysis targeted healthy HLA-A2+ donors to allow comparison with responses to the well-studied influenza matrix protein 1 epitope. Although influenza matrix protein 1 was consistently detected in all individual samples in our study, the response to this epitope was only immunodominant in three of eight, whereas for the other five, prominent CD8+ T-cell responses tended to focus on various peptides from the influenza nucleoprotein that were not presented by HLA-A2. Importantly, with the four immunodominant T-cell epitopes identified here, only one would have been detected by the current prediction programs. The other three peptides would have been either considered too long or classified as not containing typical HLA binding motifs. Our data stress the importance of systematic analysis for discovering HLA-dependent, immunodominant CD8 + T-cell epitopes derived from viruses and tumors. Focusing on HLA-A2 and predictive algorithms may be too limiting as we seek to develop targeted immunotherapy and vaccine strategies that depend on T cell-mediated immunity.
Persistent Identifierhttp://hdl.handle.net/10722/241198
ISSN
2023 Impact Factor: 9.4
2023 SCImago Journal Rankings: 3.737
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWu, Chao-
dc.contributor.authorZanker, Damien-
dc.contributor.authorValkenburg, Sophie-
dc.contributor.authorTan, Bee-
dc.contributor.authorKedzierska, Katherine-
dc.contributor.authorZou, Quan Ming-
dc.contributor.authorDoherty, Peter C.-
dc.contributor.authorChen, Weisan-
dc.date.accessioned2017-05-26T03:37:04Z-
dc.date.available2017-05-26T03:37:04Z-
dc.date.issued2011-
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, 2011, v. 108, n. 22, p. 9178-9183-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10722/241198-
dc.description.abstractImmunodominant T-cell responses are important for virus clearance. However, the identification of immunodominant T-cell peptide + HLA glycoprotein epitopes has been hindered by the extent of HLA polymorphism and the limitations of predictive algorithms. A simple, systematic approach has been used here to screen for immunodominant CD8+ T-cell specificities. The analysis targeted healthy HLA-A2+ donors to allow comparison with responses to the well-studied influenza matrix protein 1 epitope. Although influenza matrix protein 1 was consistently detected in all individual samples in our study, the response to this epitope was only immunodominant in three of eight, whereas for the other five, prominent CD8+ T-cell responses tended to focus on various peptides from the influenza nucleoprotein that were not presented by HLA-A2. Importantly, with the four immunodominant T-cell epitopes identified here, only one would have been detected by the current prediction programs. The other three peptides would have been either considered too long or classified as not containing typical HLA binding motifs. Our data stress the importance of systematic analysis for discovering HLA-dependent, immunodominant CD8 + T-cell epitopes derived from viruses and tumors. Focusing on HLA-A2 and predictive algorithms may be too limiting as we seek to develop targeted immunotherapy and vaccine strategies that depend on T cell-mediated immunity.-
dc.languageeng-
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of America-
dc.titleSystematic identification of immunodominant CD8<sup>+</sup> T-cell responses to influenza A virus in HLA-A2 individuals-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1073/pnas.1105624108-
dc.identifier.pmid21562214-
dc.identifier.scopuseid_2-s2.0-79959334212-
dc.identifier.volume108-
dc.identifier.issue22-
dc.identifier.spage9178-
dc.identifier.epage9183-
dc.identifier.eissn1091-6490-
dc.identifier.isiWOS:000291106200055-
dc.identifier.issnl0027-8424-

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