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- Publisher Website: 10.1073/pnas.1007270107
- Scopus: eid_2-s2.0-77955462803
- PMID: 20616031
- WOS: WOS:000279843200038
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Article: Cross-reactive CD8+ T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses
Title | Cross-reactive CD8+ T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses |
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Authors | |
Keywords | Influenza infection T-cell responses B7 allelic family NP418-426 variants |
Issue Date | 2010 |
Citation | Proceedings of the National Academy of Sciences of the United States of America, 2010, v. 107, n. 28, p. 12599-12604 How to Cite? |
Abstract | Preexisting T-cell immunity directed at conserved viral regions promotes enhanced recovery from influenza virus infections, with there being some evidence of cross-protection directed at variable peptides. Strikingly, many of the immunogenic peptides derived from the current pandemic A (H1N1)-2009 influenza virus are representative of the catastrophic 1918 "Spanish flu" rather than more recent "seasonal" strains. We present immunological and structural analyses of cross-reactive CD8+ T-cell-mediated immunity directed at a variable (although highly cross-reactive) immunodominant NP418-426 peptide that binds to a large B7 family (HLA-B*3501/03/0702) found throughout human populations. Memory CD8 + T-cell specificity was probed for 12 different NP418 mutants that emerged over the 9 decades between the 1918 and 2009 pandemics. Although there is evidence of substantial cross-reactivity among seasonal NP418 mutants, current memory T-cell profiles show no preexisting immunity to the 2009-NP418 variant or the 1918-NP418 variant. Natural infection with the A (H1N1)-2009 virus, however, elicits CD8+ T cells specific for the 2009-NP418 and 1918-NP 418 epitopes. This analysis points to the potential importance of cross-reactive T-cell populations that cover the possible spectrum of T-cell variants and suggests that the identification of key residues/motifs that elicit cross-reactive T-cell sets could facilitate the evolution of immunization protocols that provide a measure of protection against unpredicted pandemic influenza viruses. Thus, it is worth exploring the potential of vaccines that incorporate peptide variants with a proven potential for broader immunogenicity, especially to those that are not recognized by the current memory T-cell pool generated by exposure to influenza variants that cause successive seasonal epidemics. |
Persistent Identifier | http://hdl.handle.net/10722/241185 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 3.737 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Gras, Stephanie | - |
dc.contributor.author | Kedzierski, Lukasz | - |
dc.contributor.author | Valkenburg, Sophie A. | - |
dc.contributor.author | Laurie, Karen | - |
dc.contributor.author | Liu, Yu Chih | - |
dc.contributor.author | Denholm, Justin T. | - |
dc.contributor.author | Richards, Michael J. | - |
dc.contributor.author | Rimmelzwaan, Guus F. | - |
dc.contributor.author | Kelso, Anne | - |
dc.contributor.author | Doherty, Peter C. | - |
dc.contributor.author | Turner, Stephen J. | - |
dc.contributor.author | Rossjohn, Jamie | - |
dc.contributor.author | Kedzierska, Katherine | - |
dc.date.accessioned | 2017-05-26T03:37:02Z | - |
dc.date.available | 2017-05-26T03:37:02Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, 2010, v. 107, n. 28, p. 12599-12604 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10722/241185 | - |
dc.description.abstract | Preexisting T-cell immunity directed at conserved viral regions promotes enhanced recovery from influenza virus infections, with there being some evidence of cross-protection directed at variable peptides. Strikingly, many of the immunogenic peptides derived from the current pandemic A (H1N1)-2009 influenza virus are representative of the catastrophic 1918 "Spanish flu" rather than more recent "seasonal" strains. We present immunological and structural analyses of cross-reactive CD8+ T-cell-mediated immunity directed at a variable (although highly cross-reactive) immunodominant NP418-426 peptide that binds to a large B7 family (HLA-B*3501/03/0702) found throughout human populations. Memory CD8 + T-cell specificity was probed for 12 different NP418 mutants that emerged over the 9 decades between the 1918 and 2009 pandemics. Although there is evidence of substantial cross-reactivity among seasonal NP418 mutants, current memory T-cell profiles show no preexisting immunity to the 2009-NP418 variant or the 1918-NP418 variant. Natural infection with the A (H1N1)-2009 virus, however, elicits CD8+ T cells specific for the 2009-NP418 and 1918-NP 418 epitopes. This analysis points to the potential importance of cross-reactive T-cell populations that cover the possible spectrum of T-cell variants and suggests that the identification of key residues/motifs that elicit cross-reactive T-cell sets could facilitate the evolution of immunization protocols that provide a measure of protection against unpredicted pandemic influenza viruses. Thus, it is worth exploring the potential of vaccines that incorporate peptide variants with a proven potential for broader immunogenicity, especially to those that are not recognized by the current memory T-cell pool generated by exposure to influenza variants that cause successive seasonal epidemics. | - |
dc.language | eng | - |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.subject | Influenza infection | - |
dc.subject | T-cell responses | - |
dc.subject | B7 allelic family | - |
dc.subject | NP418-426 variants | - |
dc.title | Cross-reactive CD8+ T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1073/pnas.1007270107 | - |
dc.identifier.pmid | 20616031 | - |
dc.identifier.scopus | eid_2-s2.0-77955462803 | - |
dc.identifier.volume | 107 | - |
dc.identifier.issue | 28 | - |
dc.identifier.spage | 12599 | - |
dc.identifier.epage | 12604 | - |
dc.identifier.eissn | 1091-6490 | - |
dc.identifier.isi | WOS:000279843200038 | - |
dc.identifier.issnl | 0027-8424 | - |