File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1002/nur.20187
- Scopus: eid_2-s2.0-34250823480
- PMID: 17514720
- WOS: WOS:000246939200003
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: High-density lipoprotein prevents organ damage in endotoxemia
Title | High-density lipoprotein prevents organ damage in endotoxemia |
---|---|
Authors | |
Keywords | Animal model Lipoprotein Organ damage Endotoxemia |
Issue Date | 2007 |
Citation | Research in Nursing and Health, 2007, v. 30, n. 3, p. 250-260 How to Cite? |
Abstract | High-density lipoprotein (HDL) may decrease organ injury in sepsis. This study was designed using an animal model to mimic people who had a high HDL level and to test HDL effects on preventing organ damage in endotoxemia. Endotoxemia was induced by an infusion of lipopolysac-charide (LPS) after HDL or LDL administration. Levels of blood biochemical substances, nitrate/nitrite, and TNF-α in sera were measured. Pathological examinations were performed 72 hours after LPS infusion. HDL decreased the endotoxin-induced elevation of AST, ALT, BUN, creatinine, LDH, CPK, nitrate/nitrite, and TNF-α. On histological examination, neutrophil infiltration was lower in the HDL group. HDL had a significant effect in preventing endotoxin-induced organ damage. © 2007 Wiley Periodicals, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/241145 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.712 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Ru Ping | - |
dc.contributor.author | Lin, Nien Tsung | - |
dc.contributor.author | Chao, Yann Fen Chiou | - |
dc.contributor.author | Lin, Chia Chin | - |
dc.contributor.author | Harn, Horng Jyh | - |
dc.contributor.author | Chen, Hsing I. | - |
dc.date.accessioned | 2017-05-26T03:36:56Z | - |
dc.date.available | 2017-05-26T03:36:56Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Research in Nursing and Health, 2007, v. 30, n. 3, p. 250-260 | - |
dc.identifier.issn | 0160-6891 | - |
dc.identifier.uri | http://hdl.handle.net/10722/241145 | - |
dc.description.abstract | High-density lipoprotein (HDL) may decrease organ injury in sepsis. This study was designed using an animal model to mimic people who had a high HDL level and to test HDL effects on preventing organ damage in endotoxemia. Endotoxemia was induced by an infusion of lipopolysac-charide (LPS) after HDL or LDL administration. Levels of blood biochemical substances, nitrate/nitrite, and TNF-α in sera were measured. Pathological examinations were performed 72 hours after LPS infusion. HDL decreased the endotoxin-induced elevation of AST, ALT, BUN, creatinine, LDH, CPK, nitrate/nitrite, and TNF-α. On histological examination, neutrophil infiltration was lower in the HDL group. HDL had a significant effect in preventing endotoxin-induced organ damage. © 2007 Wiley Periodicals, Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Research in Nursing and Health | - |
dc.subject | Animal model | - |
dc.subject | Lipoprotein | - |
dc.subject | Organ damage | - |
dc.subject | Endotoxemia | - |
dc.title | High-density lipoprotein prevents organ damage in endotoxemia | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/nur.20187 | - |
dc.identifier.pmid | 17514720 | - |
dc.identifier.scopus | eid_2-s2.0-34250823480 | - |
dc.identifier.volume | 30 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 250 | - |
dc.identifier.epage | 260 | - |
dc.identifier.eissn | 1098-240X | - |
dc.identifier.isi | WOS:000246939200003 | - |
dc.identifier.issnl | 0160-6891 | - |