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Article: Comparison of the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year retrospective study
Title | Comparison of the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year retrospective study |
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Authors | |
Keywords | Ocular surface disease Severe cutaneous adverse reactions Stevens-Johnson syndrome Toxic epidermal necrolysis Asians |
Issue Date | 2017 |
Publisher | BioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcophthalmol/ |
Citation | BMC Ophthalmology, 2017, v. 17, article no. 65, p. 1-7 How to Cite? |
Abstract | Background:
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening conditions that initially affect the skin and mucous membranes. The aim of this study was to compare the acute ocular manifestations between SJS and TEN.
Methods:
The initial presenting ophthalmic records of patients with either SJS (<30% body surface area involvement) or TEN (> = 30% involvement), who were treated at one tertiary burn center in Hong Kong between 1999 and 2014, were retrospectively analyzed and compared.
Results:
A total of 20 SJS and 12 TEN cases were included. All were drug-induced. The patient demographics and treatment received were comparable. Overall, 40% of SJS and 75% of TEN patients had acute ocular surface inflammation. When comparing the two groups, there was a significant difference in the number of cases with mild involvement (5% in SJS, 42% in TEN, p = 0.01), while no statistically significant differences were found (p > 0.05) comparing between the moderate (15% in SJS, 0% in TEN) and severe groups (20% in SJS, 33% in TEN).
Conclusions:
Ocular surface inflammation was common during the acute phase in both SJS and TEN. TEN had a significantly higher number of cases with mild ocular involvement when compared with SJS, but no significant difference between the number of moderate and severe cases between the two groups. |
Persistent Identifier | http://hdl.handle.net/10722/240879 |
ISSN | 2023 Impact Factor: 1.7 2023 SCImago Journal Rankings: 0.749 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chow, LWL | - |
dc.contributor.author | Shih, KC | - |
dc.contributor.author | Chan, CYJ | - |
dc.contributor.author | Lai, JSM | - |
dc.contributor.author | Ng, LKA | - |
dc.date.accessioned | 2017-05-22T09:18:44Z | - |
dc.date.available | 2017-05-22T09:18:44Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | BMC Ophthalmology, 2017, v. 17, article no. 65, p. 1-7 | - |
dc.identifier.issn | 1471-2415 | - |
dc.identifier.uri | http://hdl.handle.net/10722/240879 | - |
dc.description.abstract | Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening conditions that initially affect the skin and mucous membranes. The aim of this study was to compare the acute ocular manifestations between SJS and TEN. Methods: The initial presenting ophthalmic records of patients with either SJS (<30% body surface area involvement) or TEN (> = 30% involvement), who were treated at one tertiary burn center in Hong Kong between 1999 and 2014, were retrospectively analyzed and compared. Results: A total of 20 SJS and 12 TEN cases were included. All were drug-induced. The patient demographics and treatment received were comparable. Overall, 40% of SJS and 75% of TEN patients had acute ocular surface inflammation. When comparing the two groups, there was a significant difference in the number of cases with mild involvement (5% in SJS, 42% in TEN, p = 0.01), while no statistically significant differences were found (p > 0.05) comparing between the moderate (15% in SJS, 0% in TEN) and severe groups (20% in SJS, 33% in TEN). Conclusions: Ocular surface inflammation was common during the acute phase in both SJS and TEN. TEN had a significantly higher number of cases with mild ocular involvement when compared with SJS, but no significant difference between the number of moderate and severe cases between the two groups. | - |
dc.language | eng | - |
dc.publisher | BioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcophthalmol/ | - |
dc.relation.ispartof | BMC Ophthalmology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Ocular surface disease | - |
dc.subject | Severe cutaneous adverse reactions | - |
dc.subject | Stevens-Johnson syndrome | - |
dc.subject | Toxic epidermal necrolysis | - |
dc.subject | Asians | - |
dc.title | Comparison of the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year retrospective study | - |
dc.type | Article | - |
dc.identifier.email | Chow, LWL: llwchow@hku.hk | - |
dc.identifier.email | Shih, KC: kcshih@hku.hk | - |
dc.identifier.email | Chan, CYJ: chanjc@hku.hk | - |
dc.identifier.email | Lai, JSM: laism@hku.hk | - |
dc.identifier.email | Ng, LKA: nlk008@hku.hk | - |
dc.identifier.authority | Chow, LWL=rp02683 | - |
dc.identifier.authority | Shih, KC=rp01374 | - |
dc.identifier.authority | Chan, CYJ=rp01737 | - |
dc.identifier.authority | Lai, JSM=rp00295 | - |
dc.identifier.authority | Ng, LKA=rp01842 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1186/s12886-017-0464-9 | - |
dc.identifier.pmid | 28499410 | - |
dc.identifier.pmcid | PMC5427612 | - |
dc.identifier.scopus | eid_2-s2.0-85018876758 | - |
dc.identifier.hkuros | 272362 | - |
dc.identifier.volume | 17 | - |
dc.identifier.spage | article no. 65, p. 1 | - |
dc.identifier.epage | article no. 65, p. 7 | - |
dc.identifier.isi | WOS:000401117100002 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1471-2415 | - |