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Article: Prevention of secondary caries using silver diamine fluoride treatment and casein phosphopeptide-amorphous calcium phosphate modified glass-ionomer cement
Title | Prevention of secondary caries using silver diamine fluoride treatment and casein phosphopeptide-amorphous calcium phosphate modified glass-ionomer cement |
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Authors | |
Keywords | Caries CPP-ACP Glass-ionomer cement Silver diamine fluoride |
Issue Date | 2017 |
Publisher | Elsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jdent |
Citation | Journal of Dentistry, 2017, v. 57, p. 38-44 How to Cite? |
Abstract | Objective: To study the effect of silver diamine fluoride (SDF) treatment and incorporating casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) into a glass-ionomer cement (GIC) to prevent secondary caries.
Method: A cervical cavity was prepared on 32 premolars for the following restoration groups: group 1, conventional GIC restoration; group 2, SDF (38%) treatment and conventional GIC restoration; group 3, CPP-ACP (3%) modified GIC; and group 4, SDF treatment and CPP-ACP modified GIC. The restored teeth were thermal-cycled before undergoing a multi-species cariogenic biofilm challenge. The restored teeth were examined by micro-computed tomography (micro-CT), scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM/EDX) and Fourier transform infrared (FTIR) spectroscopy. Data were analyzed by two-way ANOVA.
Results: Micro-CT determined outer lesion depths for groups 1–4 were: 123 ± 6 μm, 87 ± 7 μm, 79 ± 3 μm and 68 ± 5 μm respectively. An interaction effect on the outer lesion depth was found between the restorative materials and SDF treatment (p < 0.001). Both SDF treatment and modification with CPP-ACP had a significant effect on outer lesion depth (p < 0.001). SEM/EDX showed an increase of calcium and phosphorus at the root dentine adjacent to the restoration in groups 3 and 4 (CPP-ACP modified GIC). FTIR revealed that SDF treatment and CPP-ACP modified GIC had a significant effect on amide I-to-hydrogen phosphate ratio on the material-root interface (p = 0.001).
Conclusion: SDF treatment and incorporation of CPP-ACP into GIC restorative material can prevent secondary root caries development.
Clinical significance: The results provide useful information to dentists in formulating clinical management protocols and material when treating root caries. |
Persistent Identifier | http://hdl.handle.net/10722/240227 |
ISSN | 2023 Impact Factor: 4.8 2023 SCImago Journal Rankings: 1.313 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhao, IS | - |
dc.contributor.author | Mei, ML | - |
dc.contributor.author | Burrow, MF | - |
dc.contributor.author | Lo, ECM | - |
dc.contributor.author | Chu, CH | - |
dc.date.accessioned | 2017-04-19T08:21:34Z | - |
dc.date.available | 2017-04-19T08:21:34Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Journal of Dentistry, 2017, v. 57, p. 38-44 | - |
dc.identifier.issn | 0300-5712 | - |
dc.identifier.uri | http://hdl.handle.net/10722/240227 | - |
dc.description.abstract | Objective: To study the effect of silver diamine fluoride (SDF) treatment and incorporating casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) into a glass-ionomer cement (GIC) to prevent secondary caries. Method: A cervical cavity was prepared on 32 premolars for the following restoration groups: group 1, conventional GIC restoration; group 2, SDF (38%) treatment and conventional GIC restoration; group 3, CPP-ACP (3%) modified GIC; and group 4, SDF treatment and CPP-ACP modified GIC. The restored teeth were thermal-cycled before undergoing a multi-species cariogenic biofilm challenge. The restored teeth were examined by micro-computed tomography (micro-CT), scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM/EDX) and Fourier transform infrared (FTIR) spectroscopy. Data were analyzed by two-way ANOVA. Results: Micro-CT determined outer lesion depths for groups 1–4 were: 123 ± 6 μm, 87 ± 7 μm, 79 ± 3 μm and 68 ± 5 μm respectively. An interaction effect on the outer lesion depth was found between the restorative materials and SDF treatment (p < 0.001). Both SDF treatment and modification with CPP-ACP had a significant effect on outer lesion depth (p < 0.001). SEM/EDX showed an increase of calcium and phosphorus at the root dentine adjacent to the restoration in groups 3 and 4 (CPP-ACP modified GIC). FTIR revealed that SDF treatment and CPP-ACP modified GIC had a significant effect on amide I-to-hydrogen phosphate ratio on the material-root interface (p = 0.001). Conclusion: SDF treatment and incorporation of CPP-ACP into GIC restorative material can prevent secondary root caries development. Clinical significance: The results provide useful information to dentists in formulating clinical management protocols and material when treating root caries. | - |
dc.language | eng | - |
dc.publisher | Elsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jdent | - |
dc.relation.ispartof | Journal of Dentistry | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Caries | - |
dc.subject | CPP-ACP | - |
dc.subject | Glass-ionomer cement | - |
dc.subject | Silver diamine fluoride | - |
dc.title | Prevention of secondary caries using silver diamine fluoride treatment and casein phosphopeptide-amorphous calcium phosphate modified glass-ionomer cement | - |
dc.type | Article | - |
dc.identifier.email | Zhao, IS: zhao110@hku.hk | - |
dc.identifier.email | Mei, ML: mei1123@hku.hk | - |
dc.identifier.email | Burrow, MF: mfburr58@hku.hk | - |
dc.identifier.email | Lo, ECM: edward-lo@hku.hk | - |
dc.identifier.email | Chu, CH: chchu@hku.hk | - |
dc.identifier.authority | Mei, ML=rp01840 | - |
dc.identifier.authority | Burrow, MF=rp01306 | - |
dc.identifier.authority | Lo, ECM=rp00015 | - |
dc.identifier.authority | Chu, CH=rp00022 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1016/j.jdent.2016.12.001 | - |
dc.identifier.pmid | 27939657 | - |
dc.identifier.scopus | eid_2-s2.0-85008210917 | - |
dc.identifier.hkuros | 271806 | - |
dc.identifier.volume | 57 | - |
dc.identifier.spage | 38 | - |
dc.identifier.epage | 44 | - |
dc.identifier.isi | WOS:000394398500007 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0300-5712 | - |