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Conference Paper: Inhibition of ornithine decarboxylase facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models

TitleInhibition of ornithine decarboxylase facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models
Authors
Lam, SKXu, SHo, JCM
Issue Date2017
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/
Citation
The 22nd Medical Research Conference (MRC 2017), Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 14 January 2017. In Hong Kong Medical Journal, 2017, v. 23 n. 1 suppl. 1, p. 26, abstrcat no. 33 How to Cite?
AbstractINTRODUCTION: Arginine depletion has shown anticancer effects among arginine auxotrophic cancers. Pegylated arginase (BCT-100) depletes arginine by converting arginine to ornithine. In this study, BCT-100 inhibited cell growth in a panel of lung adenocarcinoma cell lines while stimulated tumor growth in most lung adenocarcinoma xenograft models. Furthermore, ornithine decarboxylase (ODC) was induced by BCT-100 in two solid xenograft models with tumor growth stimulating effect. We postulate that accumulated ornithine was used to produce polyamines by ODC which promoted tumor growth. And ODC inhibition might rescue the therapeutic effect of BCT-100 treatment in lung adenocarcinoma ...
Persistent Identifierhttp://hdl.handle.net/10722/240126
ISSN
1024-2708
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 0.261

 

DC FieldValueLanguage
dc.contributor.authorLam, SK-
dc.contributor.authorXu, S-
dc.contributor.authorHo, JCM-
dc.date.accessioned2017-04-13T00:59:37Z-
dc.date.available2017-04-13T00:59:37Z-
dc.date.issued2017-
dc.identifier.citationThe 22nd Medical Research Conference (MRC 2017), Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 14 January 2017. In Hong Kong Medical Journal, 2017, v. 23 n. 1 suppl. 1, p. 26, abstrcat no. 33-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/240126-
dc.description.abstractINTRODUCTION: Arginine depletion has shown anticancer effects among arginine auxotrophic cancers. Pegylated arginase (BCT-100) depletes arginine by converting arginine to ornithine. In this study, BCT-100 inhibited cell growth in a panel of lung adenocarcinoma cell lines while stimulated tumor growth in most lung adenocarcinoma xenograft models. Furthermore, ornithine decarboxylase (ODC) was induced by BCT-100 in two solid xenograft models with tumor growth stimulating effect. We postulate that accumulated ornithine was used to produce polyamines by ODC which promoted tumor growth. And ODC inhibition might rescue the therapeutic effect of BCT-100 treatment in lung adenocarcinoma ...-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/-
dc.relation.ispartofHong Kong Medical Journal-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleInhibition of ornithine decarboxylase facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models-
dc.typeConference_Paper-
dc.identifier.emailLam, SK: sklam77@hku.hk-
dc.identifier.emailHo, JCM: jhocm@hku.hk-
dc.identifier.authorityHo, JCM=rp00258-
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros271713-
dc.identifier.volume23-
dc.identifier.issue1 suppl. 1-
dc.identifier.spage26, abstrcat no. 33-
dc.identifier.epage26, abstrcat no. 33-
dc.publisher.placeHong Kong-
dc.identifier.issnl1024-2708-

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