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Book Chapter: Role of the Hypoxia-Inducible Factor in Periodontal Inflammation
Title | Role of the Hypoxia-Inducible Factor in Periodontal Inflammation |
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Authors | |
Keywords | Cell hypoxia Chronic periodontitis Hypoxia-inducible factor-1 Alpha subunit |
Issue Date | 2017 |
Publisher | InTech |
Citation | Role of the Hypoxia-Inducible Factor in Periodontal Inflammation. In Zheng, J & Zhou, C (Eds.), Hypoxia and Human Diseases, p. 285-302. Rijeka, Croatia: InTech, 2017 How to Cite? |
Abstract | Human periodontitis is a chronic inflammatory disease induced by opportunistic Gram-negative anaerobic bacteria at the tooth-supporting apparatus. Within the gingivitis-affected sulcus or periodontal pocket, the resident anaerobic bacteria interact with the host inflammatory reactions leading to a lower oxygen or hypoxic environment. A cellular/tissue oxygen-sensing mechanism and its appropriate regulation are needed to assist tissue adaptation to natural/pathology-induced variations in oxygen availability. In this chapter, we reviewed the biological relevance of hypoxia in periodontal/oral cellular development, epithelial barrier function, periodontal inflammation, and immunity. The role of hypoxia-inducible factor-1α in pathogen-host cross talk and alveolar bone homeostasis was also discussed. The naturally occurring pathophysiological process of hypoxia appeared to entail fundamental relevance for periodontal defense and regeneration. |
Persistent Identifier | http://hdl.handle.net/10722/239623 |
ISBN |
DC Field | Value | Language |
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dc.contributor.author | Wang, XX | - |
dc.contributor.author | Chen, Y | - |
dc.contributor.author | Leung, WK | - |
dc.date.accessioned | 2017-03-21T09:16:40Z | - |
dc.date.available | 2017-03-21T09:16:40Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Role of the Hypoxia-Inducible Factor in Periodontal Inflammation. In Zheng, J & Zhou, C (Eds.), Hypoxia and Human Diseases, p. 285-302. Rijeka, Croatia: InTech, 2017 | - |
dc.identifier.isbn | 9789535128953 | - |
dc.identifier.uri | http://hdl.handle.net/10722/239623 | - |
dc.description.abstract | Human periodontitis is a chronic inflammatory disease induced by opportunistic Gram-negative anaerobic bacteria at the tooth-supporting apparatus. Within the gingivitis-affected sulcus or periodontal pocket, the resident anaerobic bacteria interact with the host inflammatory reactions leading to a lower oxygen or hypoxic environment. A cellular/tissue oxygen-sensing mechanism and its appropriate regulation are needed to assist tissue adaptation to natural/pathology-induced variations in oxygen availability. In this chapter, we reviewed the biological relevance of hypoxia in periodontal/oral cellular development, epithelial barrier function, periodontal inflammation, and immunity. The role of hypoxia-inducible factor-1α in pathogen-host cross talk and alveolar bone homeostasis was also discussed. The naturally occurring pathophysiological process of hypoxia appeared to entail fundamental relevance for periodontal defense and regeneration. | - |
dc.language | eng | - |
dc.publisher | InTech | - |
dc.relation.ispartof | Hypoxia and Human Diseases | - |
dc.subject | Cell hypoxia | - |
dc.subject | Chronic periodontitis | - |
dc.subject | Hypoxia-inducible factor-1 | - |
dc.subject | Alpha subunit | - |
dc.title | Role of the Hypoxia-Inducible Factor in Periodontal Inflammation | - |
dc.type | Book_Chapter | - |
dc.identifier.email | Leung, WK: ewkleung@hkucc.hku.hk | - |
dc.identifier.authority | Leung, WK=rp00019 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.5772/66037 | - |
dc.identifier.hkuros | 271553 | - |
dc.identifier.spage | 285 | - |
dc.identifier.epage | 302 | - |
dc.publisher.place | Rijeka, Croatia | - |