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- Publisher Website: 10.1515/jbcpp-2016-0110
- Scopus: eid_2-s2.0-85019145115
- PMID: 28063261
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Article: Isolated heart models for studying cardiac electrophysiology: a historical perspective and recent advances
Title | Isolated heart models for studying cardiac electrophysiology: a historical perspective and recent advances |
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Authors | |
Keywords | Animal models Cardiac electrophysiology Langendorff mode Perfusate composition Perfusion methods Species differences Working mode |
Issue Date | 2017 |
Publisher | Walter de Gruyter GmbH. The Journal's web site is located at http://www.degruyter.com/view/j/jbcpp |
Citation | Journal of Basic and Clinical Physiology and Pharmacology, 2017, v. 28 n. 3, p. 191-200 How to Cite? |
Abstract | Experimental models used in cardiovascular research range from cellular to whole heart preparations. Isolated whole hearts show higher levels of structural and functional integration than lower level models such as tissues or cellular fragments. Cardiovascular diseases are multi-factorial problems that are dependent on highly organized structures rather than on molecular or cellular components alone. This article first provides a general introduction on the animal models of cardiovascular diseases. It is followed by a detailed overview and a historical perspective of the different isolated heart systems with a particular focus on the Langendorff perfusion method for the study of cardiac arrhythmias. The choice of species, perfusion method, and perfusate composition are discussed in further detail with particular considerations of the theoretical and practical aspects of experimental settings. |
Persistent Identifier | http://hdl.handle.net/10722/238673 |
ISSN | 2023 SCImago Journal Rankings: 0.399 |
DC Field | Value | Language |
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dc.contributor.author | Yeo, JM | - |
dc.contributor.author | Tse, V | - |
dc.contributor.author | Kung, J | - |
dc.contributor.author | Lin, HY | - |
dc.contributor.author | Lee, YT | - |
dc.contributor.author | Kwan, J | - |
dc.contributor.author | Yan, BP | - |
dc.contributor.author | Tse, G | - |
dc.date.accessioned | 2017-02-20T01:24:36Z | - |
dc.date.available | 2017-02-20T01:24:36Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Journal of Basic and Clinical Physiology and Pharmacology, 2017, v. 28 n. 3, p. 191-200 | - |
dc.identifier.issn | 0792-6855 | - |
dc.identifier.uri | http://hdl.handle.net/10722/238673 | - |
dc.description.abstract | Experimental models used in cardiovascular research range from cellular to whole heart preparations. Isolated whole hearts show higher levels of structural and functional integration than lower level models such as tissues or cellular fragments. Cardiovascular diseases are multi-factorial problems that are dependent on highly organized structures rather than on molecular or cellular components alone. This article first provides a general introduction on the animal models of cardiovascular diseases. It is followed by a detailed overview and a historical perspective of the different isolated heart systems with a particular focus on the Langendorff perfusion method for the study of cardiac arrhythmias. The choice of species, perfusion method, and perfusate composition are discussed in further detail with particular considerations of the theoretical and practical aspects of experimental settings. | - |
dc.language | eng | - |
dc.publisher | Walter de Gruyter GmbH. The Journal's web site is located at http://www.degruyter.com/view/j/jbcpp | - |
dc.relation.ispartof | Journal of Basic and Clinical Physiology and Pharmacology | - |
dc.rights | © 2017 Walter de Gruyter GmbH, Berlin/Boston. The final publication is available at www.degruyter.com | - |
dc.subject | Animal models | - |
dc.subject | Cardiac electrophysiology | - |
dc.subject | Langendorff mode | - |
dc.subject | Perfusate composition | - |
dc.subject | Perfusion methods | - |
dc.subject | Species differences | - |
dc.subject | Working mode | - |
dc.title | Isolated heart models for studying cardiac electrophysiology: a historical perspective and recent advances | - |
dc.type | Article | - |
dc.identifier.email | Kwan, J: jskkwan@hku.hk | - |
dc.identifier.authority | Kwan, J=rp01868 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1515/jbcpp-2016-0110 | - |
dc.identifier.pmid | 28063261 | - |
dc.identifier.scopus | eid_2-s2.0-85019145115 | - |
dc.identifier.hkuros | 271386 | - |
dc.identifier.volume | 28 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 191 | - |
dc.identifier.epage | 200 | - |
dc.publisher.place | Germany | - |
dc.identifier.issnl | 0792-6855 | - |