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Conference Paper: Wolfberry as anti-aging to prevent and delay neurodegeneration in Alzheimer’s disease
Title | Wolfberry as anti-aging to prevent and delay neurodegeneration in Alzheimer’s disease |
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Authors | |
Issue Date | 2015 |
Publisher | ICoFF2015. |
Citation | The 6th International Conference on Food Factors (ICoFF 2015), Seoul, South Korea, 22-25 November 2015. How to Cite? |
Abstract | Alzheimer’s disease (AD) is a chronic neurodegenerative disease affecting cognitive functions.
Increasing lines of studies have revealed that there are numerous risk factors or environmental stress
inducing accumulation of pathological factors of AD, termed AD-like pathology. Depression is one of the
prominent factors leading to neurodegeneration in AD. Therefore, we attempted to investigate the
application of traditional anti-aging herbal medicine, Wolfberry (the fruit of Lycium barbarum), as
therapeutic or preventive agent against this risk factor. Our previous studies using neuronal cell cultures
have shown that polysaccharide extracted from Wolfberry can reduce β-amyloid peptide neurotoxicity.
By using corticosterone to induce depression in male rats, our recent findings have shown that Wolfberry
can reduce immobility time in a forced swimming test for testing depression behavior. All the above
improvement of animal behavior is accomplished by stimulating neurogenesis in the brain. Besides,
Wolfberry can restore the loss of synaptic proteins and spine density in the hippocampus. Taken
together, Wolfberry can stimulate neurogenesis and restore synaptic degeneration. This anti-aging
Chinese medicine can relieve depressive symptom and prevent neurodegeneration in AD. This example
can illustrate multi-targeting effects of Chinese medicine in AD and depression. |
Description | [D-8] Cognitive Function - no. 0152 |
Persistent Identifier | http://hdl.handle.net/10722/238251 |
DC Field | Value | Language |
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dc.contributor.author | Chang, RCC | - |
dc.contributor.author | Ho, YS | - |
dc.contributor.author | So, KF | - |
dc.date.accessioned | 2017-02-08T06:14:50Z | - |
dc.date.available | 2017-02-08T06:14:50Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | The 6th International Conference on Food Factors (ICoFF 2015), Seoul, South Korea, 22-25 November 2015. | - |
dc.identifier.uri | http://hdl.handle.net/10722/238251 | - |
dc.description | [D-8] Cognitive Function - no. 0152 | - |
dc.description.abstract | Alzheimer’s disease (AD) is a chronic neurodegenerative disease affecting cognitive functions. Increasing lines of studies have revealed that there are numerous risk factors or environmental stress inducing accumulation of pathological factors of AD, termed AD-like pathology. Depression is one of the prominent factors leading to neurodegeneration in AD. Therefore, we attempted to investigate the application of traditional anti-aging herbal medicine, Wolfberry (the fruit of Lycium barbarum), as therapeutic or preventive agent against this risk factor. Our previous studies using neuronal cell cultures have shown that polysaccharide extracted from Wolfberry can reduce β-amyloid peptide neurotoxicity. By using corticosterone to induce depression in male rats, our recent findings have shown that Wolfberry can reduce immobility time in a forced swimming test for testing depression behavior. All the above improvement of animal behavior is accomplished by stimulating neurogenesis in the brain. Besides, Wolfberry can restore the loss of synaptic proteins and spine density in the hippocampus. Taken together, Wolfberry can stimulate neurogenesis and restore synaptic degeneration. This anti-aging Chinese medicine can relieve depressive symptom and prevent neurodegeneration in AD. This example can illustrate multi-targeting effects of Chinese medicine in AD and depression. | - |
dc.language | eng | - |
dc.publisher | ICoFF2015. | - |
dc.relation.ispartof | International Conference on Food Factors, ICoFF 2015 | - |
dc.title | Wolfberry as anti-aging to prevent and delay neurodegeneration in Alzheimer’s disease | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Chang, RCC: rccchang@hku.hk | - |
dc.identifier.email | So, KF: hrmaskf@hku.hk | - |
dc.identifier.authority | Chang, RCC=rp00470 | - |
dc.identifier.authority | So, KF=rp00329 | - |
dc.identifier.hkuros | 263452 | - |
dc.publisher.place | South Korea | - |