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Conference Paper: Central Nervous System Inflammatory Demyelinating Disorders in the Hong Kong Chinese

TitleCentral Nervous System Inflammatory Demyelinating Disorders in the Hong Kong Chinese
Authors
Issue Date2010
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/
Citation
The 23rd Annual Scientific Meeting of the Hong Kong Neurological Society, Hong Kong, 6-7 November 2010. In Hong Kong Medical Journal, 2010, v. 16 n. 6 suppl. 5, p. 24, abstract no. S6 How to Cite?
AbstractCentral nervous system inflammatory demyelinating disorders (CNS IDD) include classical multiple sclerosis, neuromyelitis optica (NMO) spectrum disorders, a single attack of/recurrent acute disseminated encephalomyelitis, a single attack of idiopathic acute transverse myelitis, optic neuritis (ON) and brainstem encephalitis. CNS IDD are potentially serious disorders with risks of mortality and significant disability. Typical relapsing forms of CNS IDD are relapsing remitting multiple sclerosis and relapsing NMO. Relapsing NMO is typified by recurrent longitudinally extensive transverse myelitis and severe unilateral or bilateral ON. Early diagnosis of CNS IDD is important as long-term treatment for different forms varies. Recognition of clinical, radiological and serological characteristics of different forms of CNS IDD facilitates early diagnoses. A significant proportion of NMO patients are seropositive for autoantibodies against aquaporin-4, the most abundant water channel in the CNS; this supports the hypothesis that NMO is an autoimmune disorder. Is NMO an autoantibody-mediated disorder sharing similar pathogenesis with myasthenia gravis (MG), a classical autoantibody-mediated autoimmune disease? An interesting observation is that paraneoplastic NMO associated various tumours is recognised recently, suggesting similarity with MG which is associated with thymoma in about 15 to 20% of patients.
Persistent Identifierhttp://hdl.handle.net/10722/238229
ISSN
2019 Impact Factor: 1.679
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorChan, KH-
dc.contributor.authorKwan, JSC-
dc.contributor.authorHo, PWL-
dc.contributor.authorHo, JWM-
dc.contributor.authorChu, ACY-
dc.contributor.authorRamsden, DB-
dc.date.accessioned2017-02-07T06:57:13Z-
dc.date.available2017-02-07T06:57:13Z-
dc.date.issued2010-
dc.identifier.citationThe 23rd Annual Scientific Meeting of the Hong Kong Neurological Society, Hong Kong, 6-7 November 2010. In Hong Kong Medical Journal, 2010, v. 16 n. 6 suppl. 5, p. 24, abstract no. S6-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/238229-
dc.description.abstractCentral nervous system inflammatory demyelinating disorders (CNS IDD) include classical multiple sclerosis, neuromyelitis optica (NMO) spectrum disorders, a single attack of/recurrent acute disseminated encephalomyelitis, a single attack of idiopathic acute transverse myelitis, optic neuritis (ON) and brainstem encephalitis. CNS IDD are potentially serious disorders with risks of mortality and significant disability. Typical relapsing forms of CNS IDD are relapsing remitting multiple sclerosis and relapsing NMO. Relapsing NMO is typified by recurrent longitudinally extensive transverse myelitis and severe unilateral or bilateral ON. Early diagnosis of CNS IDD is important as long-term treatment for different forms varies. Recognition of clinical, radiological and serological characteristics of different forms of CNS IDD facilitates early diagnoses. A significant proportion of NMO patients are seropositive for autoantibodies against aquaporin-4, the most abundant water channel in the CNS; this supports the hypothesis that NMO is an autoimmune disorder. Is NMO an autoantibody-mediated disorder sharing similar pathogenesis with myasthenia gravis (MG), a classical autoantibody-mediated autoimmune disease? An interesting observation is that paraneoplastic NMO associated various tumours is recognised recently, suggesting similarity with MG which is associated with thymoma in about 15 to 20% of patients.-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/-
dc.relation.ispartofHong Kong Medical Journal-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleCentral Nervous System Inflammatory Demyelinating Disorders in the Hong Kong Chinese-
dc.typeConference_Paper-
dc.identifier.emailChan, KH: koonho@hku.hk-
dc.identifier.authorityChan, KH=rp00537-
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros214016-
dc.identifier.hkuros172613-
dc.identifier.volume16-
dc.identifier.issue6 suppl. 5-
dc.identifier.spage24, abstract no. S6-
dc.identifier.epage24, abstract no. S6-
dc.publisher.placeHong Kong-

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