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- Publisher Website: 10.1152/ajpheart.00733.2013
- Scopus: eid_2-s2.0-84892609853
- PMID: 24213613
- WOS: WOS:000329984300015
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Article: Protective effects of histamine on Gq-mediated relaxation in regenerated endothelium
Title | Protective effects of histamine on Gq-mediated relaxation in regenerated endothelium |
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Authors | |
Keywords | Bradykinin Endothelial cells Histamine |
Issue Date | 2014 |
Publisher | American Physiological Society. The Journal's web site is located at http://intl-ajpheart.physiology.org/ |
Citation | American Journal of Physiology - Heart and Circulatory Physiology, 2014, v. 306, n. 2 How to Cite? |
Abstract | In the porcine coronary artery, regenerated endothelium is dysfunctional as regards the responses to endothelium-dependent agonists. The current study aimed to determine the possible involvement of histamine in such dysfunction. Pigs were treated chronically with pyrilamine (H1 receptor inhibitor, 2 mg·kg-1·day-1) with part of their coronary endothelium and allowed to regenerate for 28 days after balloon denudation. The results showed a reduction in relaxation to bradykinin (Gq protein dependent) only in the pyrilamine-treated group (area under the curve, 269.7 ± 13.4 vs. 142.0 ± 31.0, native endothelium vs. regenerated endothelium) but not in the control group (253.0 ± 22.1 vs. 231.9 ± 29.5, native endothelium vs. regenerated endothelium). The differences in the relaxation to serotonin (Gi protein dependent) between native and regenerated endothelium were not affected by the pyrilamine treatment (control group, 106.3 ± 17.0 vs. 55.61 ± 12.7; and pyrilamine group, 106.0 ± 8.20 vs. 49.30 ± 6.31, native endothelium vs. regenerated endothelium). These findings indicate that during regeneration of the endothelium, the activation of H1 receptors by endogenous histamine may be required to maintain the endothelium-dependent Gq protein-mediated relaxation to bradykinin, suggesting a beneficial role of the monoamine in the process of endothelial regeneration. © 2014 the American Physiological Society. |
Persistent Identifier | http://hdl.handle.net/10722/238098 |
ISSN | 2023 Impact Factor: 4.1 2023 SCImago Journal Rankings: 1.452 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chan, Calvin K. | - |
dc.contributor.author | Liao, Song Yan | - |
dc.contributor.author | Zhang, Yue Lin | - |
dc.contributor.author | Xu, Aimin | - |
dc.contributor.author | Tse, Hung Fat | - |
dc.contributor.author | Vanhoutte, Paul M. | - |
dc.date.accessioned | 2017-02-03T02:13:01Z | - |
dc.date.available | 2017-02-03T02:13:01Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | American Journal of Physiology - Heart and Circulatory Physiology, 2014, v. 306, n. 2 | - |
dc.identifier.issn | 0363-6135 | - |
dc.identifier.uri | http://hdl.handle.net/10722/238098 | - |
dc.description.abstract | In the porcine coronary artery, regenerated endothelium is dysfunctional as regards the responses to endothelium-dependent agonists. The current study aimed to determine the possible involvement of histamine in such dysfunction. Pigs were treated chronically with pyrilamine (H1 receptor inhibitor, 2 mg·kg-1·day-1) with part of their coronary endothelium and allowed to regenerate for 28 days after balloon denudation. The results showed a reduction in relaxation to bradykinin (Gq protein dependent) only in the pyrilamine-treated group (area under the curve, 269.7 ± 13.4 vs. 142.0 ± 31.0, native endothelium vs. regenerated endothelium) but not in the control group (253.0 ± 22.1 vs. 231.9 ± 29.5, native endothelium vs. regenerated endothelium). The differences in the relaxation to serotonin (Gi protein dependent) between native and regenerated endothelium were not affected by the pyrilamine treatment (control group, 106.3 ± 17.0 vs. 55.61 ± 12.7; and pyrilamine group, 106.0 ± 8.20 vs. 49.30 ± 6.31, native endothelium vs. regenerated endothelium). These findings indicate that during regeneration of the endothelium, the activation of H1 receptors by endogenous histamine may be required to maintain the endothelium-dependent Gq protein-mediated relaxation to bradykinin, suggesting a beneficial role of the monoamine in the process of endothelial regeneration. © 2014 the American Physiological Society. | - |
dc.language | eng | - |
dc.publisher | American Physiological Society. The Journal's web site is located at http://intl-ajpheart.physiology.org/ | - |
dc.relation.ispartof | American Journal of Physiology - Heart and Circulatory Physiology | - |
dc.subject | Bradykinin | - |
dc.subject | Endothelial cells | - |
dc.subject | Histamine | - |
dc.title | Protective effects of histamine on Gq-mediated relaxation in regenerated endothelium | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1152/ajpheart.00733.2013 | - |
dc.identifier.pmid | 24213613 | - |
dc.identifier.scopus | eid_2-s2.0-84892609853 | - |
dc.identifier.hkuros | 227966 | - |
dc.identifier.volume | 306 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | null | - |
dc.identifier.epage | null | - |
dc.identifier.eissn | 1522-1539 | - |
dc.identifier.isi | WOS:000329984300015 | - |
dc.identifier.issnl | 0363-6135 | - |