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- Publisher Website: 10.1016/S0264-410X(99)00372-2
- Scopus: eid_2-s2.0-0345633577
- PMID: 10590332
- WOS: WOS:000084600000011
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Article: Decreased antibody response among nursing home residents who received recalled influenza vaccine and results of revaccination, 1996-97
Title | Decreased antibody response among nursing home residents who received recalled influenza vaccine and results of revaccination, 1996-97 |
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Authors | |
Keywords | Elderly Potency Influenza vaccine Nursing home |
Issue Date | 2000 |
Citation | Vaccine, 2000, v. 18, n. 11-12, p. 1103-1109 How to Cite? |
Abstract | In November 1996, 11 lots of one U.S. manufacturer's 1996-97 trivalent influenza vaccine were voluntarily recalled because of decreasing potency of the A/Nanchang/933/95 (H3N2) component. Because the elderly are at high risk of developing influenza-related complications, we assessed the postvaccination antibody titers of nursing home residents who received recalled vaccine and assessed the antibody response to revaccination. Blood samples were collected 3 weeks after vaccination from 86 residents at three nursing homes who received recalled vaccine and 86 residents at three other nursing homes who received a different manufacturer's vaccine. Medical records were reviewed. Residents of one nursing home were later revaccinated. Blood samples were collected on the day of revaccination and again in 3 weeks. Serum was tested by hemagglutination inhibition for antibody to all three components of the 1996-97 influenza vaccine. The geometric mean antibody titer (GMT) (33 vs 55; p = 0.01) and the percentage of residents with an antibody titer ≥1:40 (52 vs 67%; p = 0.04) to the A/Nanchang/933/95 component were lower among residents who received recalled vaccine compared to those who received non-recalled vaccine, but had similar GMTs against the other two vaccine components. After revaccination, the GMT to A/Nanchang/933/95 increased from 24 on the day of revaccination to 39 (p = 0.01) in residents from one nursing home. Therefore, vaccination with the recalled vaccine was associated with lower postvaccination antibody titers to A/Nanchang/933/95, but not against the other two vaccine components. Revaccination was moderately effective in increasing antibody titers. With annual changes in influenza vaccine strains, routine post-release stability testing of influenza vaccine should continue. |
Persistent Identifier | http://hdl.handle.net/10722/238035 |
ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.342 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Buxton Bridges, C. | - |
dc.contributor.author | Fukuda, K. | - |
dc.contributor.author | Holman, R. C. | - |
dc.contributor.author | De Guzman, A. M. | - |
dc.contributor.author | Hodder, R. A. | - |
dc.contributor.author | Gomolin, I. H. | - |
dc.contributor.author | Galligan, G. K. | - |
dc.contributor.author | Leib, H. B. | - |
dc.contributor.author | Gallo, R. J. | - |
dc.contributor.author | Regnery, H. L. | - |
dc.contributor.author | Arden, N. H. | - |
dc.contributor.author | Cox, N. J. | - |
dc.date.accessioned | 2017-02-03T02:12:40Z | - |
dc.date.available | 2017-02-03T02:12:40Z | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Vaccine, 2000, v. 18, n. 11-12, p. 1103-1109 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.uri | http://hdl.handle.net/10722/238035 | - |
dc.description.abstract | In November 1996, 11 lots of one U.S. manufacturer's 1996-97 trivalent influenza vaccine were voluntarily recalled because of decreasing potency of the A/Nanchang/933/95 (H3N2) component. Because the elderly are at high risk of developing influenza-related complications, we assessed the postvaccination antibody titers of nursing home residents who received recalled vaccine and assessed the antibody response to revaccination. Blood samples were collected 3 weeks after vaccination from 86 residents at three nursing homes who received recalled vaccine and 86 residents at three other nursing homes who received a different manufacturer's vaccine. Medical records were reviewed. Residents of one nursing home were later revaccinated. Blood samples were collected on the day of revaccination and again in 3 weeks. Serum was tested by hemagglutination inhibition for antibody to all three components of the 1996-97 influenza vaccine. The geometric mean antibody titer (GMT) (33 vs 55; p = 0.01) and the percentage of residents with an antibody titer ≥1:40 (52 vs 67%; p = 0.04) to the A/Nanchang/933/95 component were lower among residents who received recalled vaccine compared to those who received non-recalled vaccine, but had similar GMTs against the other two vaccine components. After revaccination, the GMT to A/Nanchang/933/95 increased from 24 on the day of revaccination to 39 (p = 0.01) in residents from one nursing home. Therefore, vaccination with the recalled vaccine was associated with lower postvaccination antibody titers to A/Nanchang/933/95, but not against the other two vaccine components. Revaccination was moderately effective in increasing antibody titers. With annual changes in influenza vaccine strains, routine post-release stability testing of influenza vaccine should continue. | - |
dc.language | eng | - |
dc.relation.ispartof | Vaccine | - |
dc.subject | Elderly | - |
dc.subject | Potency | - |
dc.subject | Influenza vaccine | - |
dc.subject | Nursing home | - |
dc.title | Decreased antibody response among nursing home residents who received recalled influenza vaccine and results of revaccination, 1996-97 | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/S0264-410X(99)00372-2 | - |
dc.identifier.pmid | 10590332 | - |
dc.identifier.scopus | eid_2-s2.0-0345633577 | - |
dc.identifier.volume | 18 | - |
dc.identifier.issue | 11-12 | - |
dc.identifier.spage | 1103 | - |
dc.identifier.epage | 1109 | - |
dc.identifier.isi | WOS:000084600000011 | - |
dc.identifier.issnl | 0264-410X | - |