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Conference Paper: Cellular and molecular mechanisms underlying systemic autoimmune and inflammatory disorders
Title | Cellular and molecular mechanisms underlying systemic autoimmune and inflammatory disorders |
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Authors | |
Issue Date | 2010 |
Citation | 2nd International Forum on Rheumatoid Arthritis (第二届类风湿关节炎国际论坛), Beijing, China, 18-19 September 2010 How to Cite? |
Abstract | Lupus disease, a prototype of autoimmune and rheumatic disorders, is intriguing clinically and immunologically for its systemic nature and complexity in the pathogenesis. The initiation and perpetuation of a chronic inflammatory cascade are believed to result in multiple tissue and organ damages, but the underlying mechanisms for such a systemic loss of tolerance are still to be understood. Our studies have been focused on the roles, abnormalities, disease association and causal relationship of dendritic cells (DC), regulatory T (Treg) and B (Breg) cells in systemic autoimmunity. We showed how defects in the induction and peripheral expansion of these regulatory cells could be implicated in lupus and related inflammatory disorders. Different cytokines (IL-2, IL-10, IL-15, IL-33, IL-35) were found to be critically involved in the very processes that controlled the regulator versus effector cell expansion and functions. The therapeutic potential, as well as complications, of using these regulatory cells and molecules for treating autoimmune diseases are also discussed. |
Description | Plenary Speaker |
Persistent Identifier | http://hdl.handle.net/10722/237374 |
DC Field | Value | Language |
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dc.contributor.author | Huang, F | - |
dc.date.accessioned | 2017-01-05T08:21:01Z | - |
dc.date.available | 2017-01-05T08:21:01Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | 2nd International Forum on Rheumatoid Arthritis (第二届类风湿关节炎国际论坛), Beijing, China, 18-19 September 2010 | - |
dc.identifier.uri | http://hdl.handle.net/10722/237374 | - |
dc.description | Plenary Speaker | - |
dc.description.abstract | Lupus disease, a prototype of autoimmune and rheumatic disorders, is intriguing clinically and immunologically for its systemic nature and complexity in the pathogenesis. The initiation and perpetuation of a chronic inflammatory cascade are believed to result in multiple tissue and organ damages, but the underlying mechanisms for such a systemic loss of tolerance are still to be understood. Our studies have been focused on the roles, abnormalities, disease association and causal relationship of dendritic cells (DC), regulatory T (Treg) and B (Breg) cells in systemic autoimmunity. We showed how defects in the induction and peripheral expansion of these regulatory cells could be implicated in lupus and related inflammatory disorders. Different cytokines (IL-2, IL-10, IL-15, IL-33, IL-35) were found to be critically involved in the very processes that controlled the regulator versus effector cell expansion and functions. The therapeutic potential, as well as complications, of using these regulatory cells and molecules for treating autoimmune diseases are also discussed. | - |
dc.language | eng | - |
dc.relation.ispartof | 2nd International Forum on Rheumatoid Arthritis, 2010 | - |
dc.title | Cellular and molecular mechanisms underlying systemic autoimmune and inflammatory disorders | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Huang, F: fphuang@hku.hk | - |
dc.identifier.authority | Huang, F=rp01922 | - |
dc.identifier.hkuros | 240084 | - |