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Conference Paper: An Essential Protective Role Of IL-10-Producing Regulatory B Cells Against IL-33-Mediated Mucosal Inflammation

TitleAn Essential Protective Role Of IL-10-Producing Regulatory B Cells Against IL-33-Mediated Mucosal Inflammation
Authors
Issue Date2012
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IMM
Citation
3rd European Congress of Immunology (ECI 2012), Glasgow, Scotland, UK, 5–8 September 2012. In Immunology, 2012, v. 137 n. Suppl. 1, p. 77, abstract no. W31.003 How to Cite?
AbstractB cells with regulatory functions (Breg), as a unique cell lineage or lineages of the immune regulatory network, have attracted increasing attentions in recent years for their roles in maintaining peripheral tolerance. Interleukin 33 (IL-33), the newest IL-1 cytokine family member, has been shown to lead a double life with both pro- and anti-inflammatory properties. We report here that IL-33 treatment exacerbates, and induces an early onset of, the inflammatory bowel disease (IBD) in IL-10 deficient mice. Similarly treated wild-type control mice were however fully resistant to the IL-33-mediated disease induction. We demonstrated further that IL-33 treatment drove B cell proliferation and induced a phenotypically discrete subset (CD19+CD25+CD1dhiIgMhiCD23-) of IL-10 producing Breg-like precursor cells, which in return protected against the IL-33-mediated mucosal inflammation in normal mice. These IL-33-induced Bregs suppressed dose-dependently the proliferative responses of effector B cells in vitro and, upon adoptive transfer, significantly delayed the onset and reduced the severity of spontaneous IBD in the IL-10 deficient mice. Our findings thus provide clear evidence for an essential protective role hence therapeutic potential of the IL-10-producing Breg in the immune regulatory mechanisms against mucosal inflammatory disorders.
DescriptionECI 2012 is co-organized by the European Federation of Immunological Societies (EFIS) and The British Society for Immunology (BSI).
Theme: A healthier future through research, education and innovation
Workshop: Inflammatory Bowel Diseases
Persistent Identifierhttp://hdl.handle.net/10722/237372
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.720

 

DC FieldValueLanguage
dc.contributor.authorHuang, FP-
dc.contributor.authorSattler, S-
dc.contributor.authorLing, GS-
dc.contributor.authorXu, D-
dc.contributor.authorHussaart, L-
dc.contributor.authorRomaine, A-
dc.contributor.authorZhao, HZ-
dc.contributor.authorFossati-Jimack, LM-
dc.contributor.authorMalik, T-
dc.contributor.authorCook, HT-
dc.contributor.authorBotto, M-
dc.contributor.authorLau, YL-
dc.contributor.authorLiew, FY-
dc.date.accessioned2017-01-05T07:16:27Z-
dc.date.available2017-01-05T07:16:27Z-
dc.date.issued2012-
dc.identifier.citation3rd European Congress of Immunology (ECI 2012), Glasgow, Scotland, UK, 5–8 September 2012. In Immunology, 2012, v. 137 n. Suppl. 1, p. 77, abstract no. W31.003-
dc.identifier.issn0019-2805-
dc.identifier.urihttp://hdl.handle.net/10722/237372-
dc.descriptionECI 2012 is co-organized by the European Federation of Immunological Societies (EFIS) and The British Society for Immunology (BSI).-
dc.descriptionTheme: A healthier future through research, education and innovation-
dc.descriptionWorkshop: Inflammatory Bowel Diseases-
dc.description.abstractB cells with regulatory functions (Breg), as a unique cell lineage or lineages of the immune regulatory network, have attracted increasing attentions in recent years for their roles in maintaining peripheral tolerance. Interleukin 33 (IL-33), the newest IL-1 cytokine family member, has been shown to lead a double life with both pro- and anti-inflammatory properties. We report here that IL-33 treatment exacerbates, and induces an early onset of, the inflammatory bowel disease (IBD) in IL-10 deficient mice. Similarly treated wild-type control mice were however fully resistant to the IL-33-mediated disease induction. We demonstrated further that IL-33 treatment drove B cell proliferation and induced a phenotypically discrete subset (CD19+CD25+CD1dhiIgMhiCD23-) of IL-10 producing Breg-like precursor cells, which in return protected against the IL-33-mediated mucosal inflammation in normal mice. These IL-33-induced Bregs suppressed dose-dependently the proliferative responses of effector B cells in vitro and, upon adoptive transfer, significantly delayed the onset and reduced the severity of spontaneous IBD in the IL-10 deficient mice. Our findings thus provide clear evidence for an essential protective role hence therapeutic potential of the IL-10-producing Breg in the immune regulatory mechanisms against mucosal inflammatory disorders.-
dc.languageeng-
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IMM-
dc.relation.ispartofImmunology-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.titleAn Essential Protective Role Of IL-10-Producing Regulatory B Cells Against IL-33-Mediated Mucosal Inflammation-
dc.typeConference_Paper-
dc.identifier.emailHuang, FP: fphuang@hku.hk-
dc.identifier.emailLau, YL: lauylung@hku.hk-
dc.identifier.authorityHuang, FP=rp01922-
dc.identifier.authorityLau, YL=rp00361-
dc.identifier.doi10.1111/imm.12001-
dc.identifier.hkuros240066-
dc.identifier.volume137-
dc.identifier.issueSuppl. 1-
dc.identifier.spage77-
dc.identifier.epage77-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0019-2805-

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