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postgraduate thesis: Minimally invasive application of botulinum toxin A in patients with rhinitis

TitleMinimally invasive application of botulinum toxin A in patients with rhinitis
Authors
Issue Date2016
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
Citation
Wong, C. A. [黃俊樂]. (2016). Minimally invasive application of botulinum toxin A in patients with rhinitis. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR.
AbstractBackground: Botulinum toxin A has been investigated in the treatment of rhinitis by injection into the nasal cavity for therapy-resistant rhinitis. The aim of this study is to evaluate the effectiveness of a novel minimally invasive topical application of intranasal botulinum toxin A in the subjective relief in the symptoms of rhinitis and quality of life. Design: A prospective cohort study design Methods: 23 patients with rhinitis were studied from January 2016 to June 2016. A minimally invasive application of botulinum toxin A was investigated by applying ribbon gauze soaked with botulinum toxin A, 25 units in each nostril for 30 minutes. Visual Analog Scale (VAS) of symptoms scores (nasal congestion, rhinorrhea, post nasal drip, sneezing) and quality of life measured by Rhinoconjunctivitis Quality of Life Questionnaire Standard (RQLQ-S) were collected. The patients were followed up at weeks 1, 4, 8 and 12. Results: VAS symptoms score in the scale of 0 to 10 showed mean decrease of symptoms scores of nasal congestion (2.92, p=0.002), rhinorrhea (2.34, p=0.057), post nasal drip (1.33, p=0.283) and sneezing (0.36, p=0.030). RQLQ-S showed clinically meaningful overall improvement in quality of life (0.79, p=0.037). In the separate domains of RQLQ-S, the domains of daily activities and nasal symptoms showed statistically significant changes, with mean decrease of 0.87 in activities and 0.93 in nasal symptoms, p=0.009 and p=0.030 respectively. Conclusion: In patients with therapy-resistant rhinitis, a minimally invasive application of topical intranasal botulinum toxin A with ribbon gauze can achieve long lasting improvement in symptoms and improvement in overall quality of life and daily activities.
DegreeMaster of Public Health
SubjectRhinitis - Treatment
Botulinum toxin - Therapeutic use
Dept/ProgramPublic Health
Persistent Identifierhttp://hdl.handle.net/10722/237222
HKU Library Item IDb5805207

 

DC FieldValueLanguage
dc.contributor.authorWong, Chun-lok, Andrew-
dc.contributor.author黃俊樂-
dc.date.accessioned2016-12-28T02:01:52Z-
dc.date.available2016-12-28T02:01:52Z-
dc.date.issued2016-
dc.identifier.citationWong, C. A. [黃俊樂]. (2016). Minimally invasive application of botulinum toxin A in patients with rhinitis. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR.-
dc.identifier.urihttp://hdl.handle.net/10722/237222-
dc.description.abstractBackground: Botulinum toxin A has been investigated in the treatment of rhinitis by injection into the nasal cavity for therapy-resistant rhinitis. The aim of this study is to evaluate the effectiveness of a novel minimally invasive topical application of intranasal botulinum toxin A in the subjective relief in the symptoms of rhinitis and quality of life. Design: A prospective cohort study design Methods: 23 patients with rhinitis were studied from January 2016 to June 2016. A minimally invasive application of botulinum toxin A was investigated by applying ribbon gauze soaked with botulinum toxin A, 25 units in each nostril for 30 minutes. Visual Analog Scale (VAS) of symptoms scores (nasal congestion, rhinorrhea, post nasal drip, sneezing) and quality of life measured by Rhinoconjunctivitis Quality of Life Questionnaire Standard (RQLQ-S) were collected. The patients were followed up at weeks 1, 4, 8 and 12. Results: VAS symptoms score in the scale of 0 to 10 showed mean decrease of symptoms scores of nasal congestion (2.92, p=0.002), rhinorrhea (2.34, p=0.057), post nasal drip (1.33, p=0.283) and sneezing (0.36, p=0.030). RQLQ-S showed clinically meaningful overall improvement in quality of life (0.79, p=0.037). In the separate domains of RQLQ-S, the domains of daily activities and nasal symptoms showed statistically significant changes, with mean decrease of 0.87 in activities and 0.93 in nasal symptoms, p=0.009 and p=0.030 respectively. Conclusion: In patients with therapy-resistant rhinitis, a minimally invasive application of topical intranasal botulinum toxin A with ribbon gauze can achieve long lasting improvement in symptoms and improvement in overall quality of life and daily activities.-
dc.languageeng-
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)-
dc.relation.ispartofHKU Theses Online (HKUTO)-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.-
dc.subject.lcshRhinitis - Treatment-
dc.subject.lcshBotulinum toxin - Therapeutic use-
dc.titleMinimally invasive application of botulinum toxin A in patients with rhinitis-
dc.typePG_Thesis-
dc.identifier.hkulb5805207-
dc.description.thesisnameMaster of Public Health-
dc.description.thesislevelMaster-
dc.description.thesisdisciplinePublic Health-
dc.description.naturepublished_or_final_version-

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