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- Publisher Website: 10.1007/s11936-014-0351-0
- Scopus: eid_2-s2.0-84919905532
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Article: Childhood Obesity and Insulin Resistance: How Should It Be Managed?
Title | Childhood Obesity and Insulin Resistance: How Should It Be Managed? |
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Authors | |
Keywords | Obesity Cardiometabolic risks Child Dietary intervention Insulin resistance Metformin |
Issue Date | 2014 |
Citation | Current Treatment Options in Cardiovascular Medicine, 2014, v. 16, n. 12 How to Cite? |
Abstract | © 2014, Springer Science+Business Media New York.Concomitant with the rise in global pediatric obesity in the past decades, there has been a significant increase in the number of children and adolescents with clinical signs of insulin resistance. Given insulin resistance is the important link between obesity and the associated metabolic abnormalities and cardiovascular risk, clinicians should be aware of high risk groups and treatment options. As there is no universally accepted biochemical definition of insulin resistance in children and adolescents, identification and diagnosis of insulin resistance usually relies on clinical features such as acanthosis nigricans, polycystic ovary syndrome, hypertension, dyslipidemia, and nonalcoholic fatty liver disease. Treatment for reducing insulin resistance and other obesity-associated comorbidities should focus on changes in health behaviors to achieve effective weight management. Lifestyle interventions incorporating dietary change, increased physical activity, and decreased sedentary behaviors, with the involvement of family and adoption of a developmentally appropriate approach, should be used as the first line treatment. Current evidence suggests that the primary objective of dietary interventions should be to reduce total energy intake and a combination of aerobic and resistance training should be encouraged. Metformin can be used in conjunction with a lifestyle intervention program in obese adolescents with clinical insulin resistance to achieve weight loss and to improve insulin sensitivity. Ongoing evaluation and research are required to explore optimal protocol and long-term effectiveness of lifestyle interventions, as well as to determine whether the improvements in insulin sensitivity induced by lifestyle interventions and weight loss will lead to a clinical benefit including reduced cardiovascular morbidity and mortality. |
Persistent Identifier | http://hdl.handle.net/10722/236689 |
ISSN | 2023 Impact Factor: 0.8 2023 SCImago Journal Rankings: 0.395 |
DC Field | Value | Language |
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dc.contributor.author | Ho, Mandy | - |
dc.contributor.author | Garnett, Sarah P. | - |
dc.contributor.author | Baur, Louise A. | - |
dc.date.accessioned | 2016-12-01T09:08:36Z | - |
dc.date.available | 2016-12-01T09:08:36Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Current Treatment Options in Cardiovascular Medicine, 2014, v. 16, n. 12 | - |
dc.identifier.issn | 1092-8464 | - |
dc.identifier.uri | http://hdl.handle.net/10722/236689 | - |
dc.description.abstract | © 2014, Springer Science+Business Media New York.Concomitant with the rise in global pediatric obesity in the past decades, there has been a significant increase in the number of children and adolescents with clinical signs of insulin resistance. Given insulin resistance is the important link between obesity and the associated metabolic abnormalities and cardiovascular risk, clinicians should be aware of high risk groups and treatment options. As there is no universally accepted biochemical definition of insulin resistance in children and adolescents, identification and diagnosis of insulin resistance usually relies on clinical features such as acanthosis nigricans, polycystic ovary syndrome, hypertension, dyslipidemia, and nonalcoholic fatty liver disease. Treatment for reducing insulin resistance and other obesity-associated comorbidities should focus on changes in health behaviors to achieve effective weight management. Lifestyle interventions incorporating dietary change, increased physical activity, and decreased sedentary behaviors, with the involvement of family and adoption of a developmentally appropriate approach, should be used as the first line treatment. Current evidence suggests that the primary objective of dietary interventions should be to reduce total energy intake and a combination of aerobic and resistance training should be encouraged. Metformin can be used in conjunction with a lifestyle intervention program in obese adolescents with clinical insulin resistance to achieve weight loss and to improve insulin sensitivity. Ongoing evaluation and research are required to explore optimal protocol and long-term effectiveness of lifestyle interventions, as well as to determine whether the improvements in insulin sensitivity induced by lifestyle interventions and weight loss will lead to a clinical benefit including reduced cardiovascular morbidity and mortality. | - |
dc.language | eng | - |
dc.relation.ispartof | Current Treatment Options in Cardiovascular Medicine | - |
dc.subject | Obesity | - |
dc.subject | Cardiometabolic risks | - |
dc.subject | Child | - |
dc.subject | Dietary intervention | - |
dc.subject | Insulin resistance | - |
dc.subject | Metformin | - |
dc.title | Childhood Obesity and Insulin Resistance: How Should It Be Managed? | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s11936-014-0351-0 | - |
dc.identifier.scopus | eid_2-s2.0-84919905532 | - |
dc.identifier.volume | 16 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | null | - |
dc.identifier.epage | null | - |
dc.identifier.eissn | 1534-3189 | - |
dc.identifier.issnl | 1092-8464 | - |