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Conference Paper: Human plasma chemerin level is not associated with the severity of knee osteoarthritis
Title | Human plasma chemerin level is not associated with the severity of knee osteoarthritis |
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Authors | |
Issue Date | 2015 |
Citation | The 35th Annual Congress of The Hong Kong Orthopaedic Association (HKOA 2015), Hong Kong, 6-8 November 2015, p. 48, abstract no. 3.2 How to Cite? |
Abstract | OBJECTIVE: Adipokine-induced inflammation plays roles in the pathogenesis of human osteoarthritis (OA). Chemerin is a novel chemoattractant adipokine associated with metabolic syndrome and inflammation. This study aimed to investigate whether human plasma chemerin is associated with the severity of knee OA. METHODS: A total of 74 patients with knee OA were prospectively enrolled. The severity of OA was judged according to the Kellgren-Lawrence (KL) grading system. Patients’ age, sex, body mass index (BMI), haemoglobin A1c (HbA1c) level, and lipid profile were documented. Plasma chemerin was detected by enzyme-linked immunosorbent assay. RESULTS: A total of 54 female and 20 male patients with a mean age of 60.9 years were included. Their mean (± standard deviation) triglyceride, low-density lipoprotein, high-density lipoprotein, cholesterol, and HbA1c levels was 1.58 ± 1.00 nmol/L, 3.04 ± 0.77 nmol/L, 1.50 ± 0.44 nmol/L, 5.25 ± 0.83 nmol/L, and 5.82 ± 0.65 mmol/L, respectively. The mean plasma chemerin level of patients with KL grade 2, grade 3, and grade 4 was 57.77 ± 16.80 (n=28), 62.93 ± 20.23 (n=27) and 60.84 ± 14.43 (n=19), respectively. The one-way analysis of variance showed no significant differences among these groups (p=0.413). The bivariate correlation analysis showed that chemerin was correlated with BMI (p=0.007, r=0.310) and triglyceride level (p=0.034, r=0.247). CONCLUSIONS: Human plasma chemerin level is not associated with the severity of knee OA but is correlated with BMI and triglyceride levels. |
Description | Free Paper Session 3 - Basic Science 1: no. 3.2 |
Persistent Identifier | http://hdl.handle.net/10722/235138 |
DC Field | Value | Language |
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dc.contributor.author | Zhang, CF | - |
dc.contributor.author | Yan, CH | - |
dc.contributor.author | Chiu, PKY | - |
dc.date.accessioned | 2016-10-14T13:51:29Z | - |
dc.date.available | 2016-10-14T13:51:29Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | The 35th Annual Congress of The Hong Kong Orthopaedic Association (HKOA 2015), Hong Kong, 6-8 November 2015, p. 48, abstract no. 3.2 | - |
dc.identifier.uri | http://hdl.handle.net/10722/235138 | - |
dc.description | Free Paper Session 3 - Basic Science 1: no. 3.2 | - |
dc.description.abstract | OBJECTIVE: Adipokine-induced inflammation plays roles in the pathogenesis of human osteoarthritis (OA). Chemerin is a novel chemoattractant adipokine associated with metabolic syndrome and inflammation. This study aimed to investigate whether human plasma chemerin is associated with the severity of knee OA. METHODS: A total of 74 patients with knee OA were prospectively enrolled. The severity of OA was judged according to the Kellgren-Lawrence (KL) grading system. Patients’ age, sex, body mass index (BMI), haemoglobin A1c (HbA1c) level, and lipid profile were documented. Plasma chemerin was detected by enzyme-linked immunosorbent assay. RESULTS: A total of 54 female and 20 male patients with a mean age of 60.9 years were included. Their mean (± standard deviation) triglyceride, low-density lipoprotein, high-density lipoprotein, cholesterol, and HbA1c levels was 1.58 ± 1.00 nmol/L, 3.04 ± 0.77 nmol/L, 1.50 ± 0.44 nmol/L, 5.25 ± 0.83 nmol/L, and 5.82 ± 0.65 mmol/L, respectively. The mean plasma chemerin level of patients with KL grade 2, grade 3, and grade 4 was 57.77 ± 16.80 (n=28), 62.93 ± 20.23 (n=27) and 60.84 ± 14.43 (n=19), respectively. The one-way analysis of variance showed no significant differences among these groups (p=0.413). The bivariate correlation analysis showed that chemerin was correlated with BMI (p=0.007, r=0.310) and triglyceride level (p=0.034, r=0.247). CONCLUSIONS: Human plasma chemerin level is not associated with the severity of knee OA but is correlated with BMI and triglyceride levels. | - |
dc.language | eng | - |
dc.relation.ispartof | Annual Congress of The Hong Kong Orthopaedic Association, HKOA 2015 | - |
dc.title | Human plasma chemerin level is not associated with the severity of knee osteoarthritis | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Yan, CH: yanchoi@hku.hk | - |
dc.identifier.email | Chiu, PKY: pkychiu@hkucc.hku.hk | - |
dc.identifier.authority | Yan, CH=rp00303 | - |
dc.identifier.authority | Chiu, PKY=rp00379 | - |
dc.identifier.hkuros | 269187 | - |
dc.identifier.hkuros | 270225 | - |
dc.identifier.spage | 48, abstract no. 3.2 | - |
dc.identifier.epage | 48, abstract no. 3.2 | - |