File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.jdiacomp.2016.05.024
- Scopus: eid_2-s2.0-84990950517
- PMID: 27318537
- WOS: WOS:000382097600007
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Association of variability in hemoglobin A1c with cardiovascular diseases and mortality in Chinese patients with type 2 diabetes mellitus — A retrospective population-based cohort study
Title | Association of variability in hemoglobin A1c with cardiovascular diseases and mortality in Chinese patients with type 2 diabetes mellitus — A retrospective population-based cohort study |
---|---|
Authors | |
Keywords | Diabetes mellitus HbA1c Variability Cardiovascular diseases Mortality |
Issue Date | 2016 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jdiacomp |
Citation | Journal of Diabetes and its Complications, 2016, v. 30 n. 7, p. 1240-1247 How to Cite? |
Abstract | Aims:
This study aimed to investigate the association between variability in HbA1c and incidence of cardiovascular disease (CVD) event and mortality among Chinese primary care patients with Type 2 diabetes mellitus (T2DM).
Methods:
A retrospective cohort study was conducted on 91,866 T2DM patients aged ≥ 18 years without any history of CVD. Variability in HbA1c, was measured by standard deviation (SD), associated with the risks of CVD and all-cause mortality were evaluated using Cox proportional hazards regression analysis by age groups ( 65 and ≥ 65 years old).' to 'Variability in HbA1c was measured by standard deviation (SD) The association between Variability in HbA1c and the incidence of CVD and all-cause mortality were evaluated using Cox proportional hazards regression analysis by age groups ( 65 and ≥ 65 years old).
Results:
Over a median follow-up of 58.5 months, our study identified a positive linear relationship between variability in HbA1c and incidence of CVD and all-cause mortality in the younger and older groups. For every 1-SD increase in HbA1c, the risk of CVD events in the older group only increased by 15.2% (95% CI: 1.026–1.293), and the risks of all-cause mortality in both age groups increased by 49.5% (95% CI: 1.154–1.936) and 77.8% (95% CI: 1.563–2.024), respectively.
Conclusions:
The HbA1c variability independently of the mean HbA1c level may provide additional valuable information as a potential predictor for the development of CVD and all-cause mortality in diabetic patients, particularly for the elderly patients. |
Persistent Identifier | http://hdl.handle.net/10722/234686 |
ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 1.018 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wan, YF | - |
dc.contributor.author | Fung, SCC | - |
dc.contributor.author | Fong, DYT | - |
dc.contributor.author | Lam, CLK | - |
dc.date.accessioned | 2016-10-14T13:48:29Z | - |
dc.date.available | 2016-10-14T13:48:29Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Journal of Diabetes and its Complications, 2016, v. 30 n. 7, p. 1240-1247 | - |
dc.identifier.issn | 1056-8727 | - |
dc.identifier.uri | http://hdl.handle.net/10722/234686 | - |
dc.description.abstract | Aims: This study aimed to investigate the association between variability in HbA1c and incidence of cardiovascular disease (CVD) event and mortality among Chinese primary care patients with Type 2 diabetes mellitus (T2DM). Methods: A retrospective cohort study was conducted on 91,866 T2DM patients aged ≥ 18 years without any history of CVD. Variability in HbA1c, was measured by standard deviation (SD), associated with the risks of CVD and all-cause mortality were evaluated using Cox proportional hazards regression analysis by age groups ( 65 and ≥ 65 years old).' to 'Variability in HbA1c was measured by standard deviation (SD) The association between Variability in HbA1c and the incidence of CVD and all-cause mortality were evaluated using Cox proportional hazards regression analysis by age groups ( 65 and ≥ 65 years old). Results: Over a median follow-up of 58.5 months, our study identified a positive linear relationship between variability in HbA1c and incidence of CVD and all-cause mortality in the younger and older groups. For every 1-SD increase in HbA1c, the risk of CVD events in the older group only increased by 15.2% (95% CI: 1.026–1.293), and the risks of all-cause mortality in both age groups increased by 49.5% (95% CI: 1.154–1.936) and 77.8% (95% CI: 1.563–2.024), respectively. Conclusions: The HbA1c variability independently of the mean HbA1c level may provide additional valuable information as a potential predictor for the development of CVD and all-cause mortality in diabetic patients, particularly for the elderly patients. | - |
dc.language | eng | - |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jdiacomp | - |
dc.relation.ispartof | Journal of Diabetes and its Complications | - |
dc.subject | Diabetes mellitus | - |
dc.subject | HbA1c | - |
dc.subject | Variability | - |
dc.subject | Cardiovascular diseases | - |
dc.subject | Mortality | - |
dc.title | Association of variability in hemoglobin A1c with cardiovascular diseases and mortality in Chinese patients with type 2 diabetes mellitus — A retrospective population-based cohort study | - |
dc.type | Article | - |
dc.identifier.email | Wan, YF: yfwan@hku.hk | - |
dc.identifier.email | Fung, SCC: cfsc@hku.hk | - |
dc.identifier.email | Fong, DYT: dytfong@hku.hk | - |
dc.identifier.email | Lam, CLK: clklam@hku.hk | - |
dc.identifier.authority | Wan, YF=rp02518 | - |
dc.identifier.authority | Fung, SCC=rp01330 | - |
dc.identifier.authority | Fong, DYT=rp00253 | - |
dc.identifier.authority | Lam, CLK=rp00350 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.jdiacomp.2016.05.024 | - |
dc.identifier.pmid | 27318537 | - |
dc.identifier.scopus | eid_2-s2.0-84990950517 | - |
dc.identifier.hkuros | 269988 | - |
dc.identifier.volume | 30 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 1240 | - |
dc.identifier.epage | 1247 | - |
dc.identifier.isi | WOS:000382097600007 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1056-8727 | - |