File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Altered tooth morphogenesis after silencing the planar cell polarity core component, Vangl2

TitleAltered tooth morphogenesis after silencing the planar cell polarity core component, Vangl2
Authors
KeywordsPlanar cell polarity
Vangl2
Enamel knot
Morphogenesis
Tooth
Issue Date2016
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
Citation
Cell and Tissue Research, 2016, v. 366 n. 3, p. 617-621 How to Cite?
AbstractVangl2, one of the core components of the planar cell polarity (PCP) pathway, has an important role in the regulation of morphogenesis in several tissues. Although the expression of Vangl2 has been detected in the developing tooth, its role in tooth morphogenesis is not known. In this study, we show that Vangl2 is expressed in the inner dental epithelium (IDE) and in the secondary enamel knots (SEKs) of bell stage tooth germs. Inhibition of Vangl2 expression by siRNA treatment in in vitro-cultured tooth germs resulted in retarded tooth germ growth with deregulated cell proliferation and apoptosis. After kidney transplantation of Vangl2 siRNA-treated tooth germs, teeth were observed to be small and malformed. We also show that Vangl2 is required to maintain the proper pattern of cell alignment in SEKs, which maybe important for the function of SEKs as signaling centers. These results suggest that Vangl2 plays an important role in the morphogenesis of teeth.
Persistent Identifierhttp://hdl.handle.net/10722/234455
ISSN
2023 Impact Factor: 3.2
2023 SCImago Journal Rankings: 0.965
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWu, Z-
dc.contributor.authorEpasinghe, DJ-
dc.contributor.authorHe, J-
dc.contributor.authorLi, L-
dc.contributor.authorGreen, DW-
dc.contributor.authorLee, MJ-
dc.contributor.authorJung, HS-
dc.date.accessioned2016-10-14T13:46:59Z-
dc.date.available2016-10-14T13:46:59Z-
dc.date.issued2016-
dc.identifier.citationCell and Tissue Research, 2016, v. 366 n. 3, p. 617-621-
dc.identifier.issn0302-766X-
dc.identifier.urihttp://hdl.handle.net/10722/234455-
dc.description.abstractVangl2, one of the core components of the planar cell polarity (PCP) pathway, has an important role in the regulation of morphogenesis in several tissues. Although the expression of Vangl2 has been detected in the developing tooth, its role in tooth morphogenesis is not known. In this study, we show that Vangl2 is expressed in the inner dental epithelium (IDE) and in the secondary enamel knots (SEKs) of bell stage tooth germs. Inhibition of Vangl2 expression by siRNA treatment in in vitro-cultured tooth germs resulted in retarded tooth germ growth with deregulated cell proliferation and apoptosis. After kidney transplantation of Vangl2 siRNA-treated tooth germs, teeth were observed to be small and malformed. We also show that Vangl2 is required to maintain the proper pattern of cell alignment in SEKs, which maybe important for the function of SEKs as signaling centers. These results suggest that Vangl2 plays an important role in the morphogenesis of teeth.-
dc.languageeng-
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm-
dc.relation.ispartofCell and Tissue Research-
dc.subjectPlanar cell polarity-
dc.subjectVangl2-
dc.subjectEnamel knot-
dc.subjectMorphogenesis-
dc.subjectTooth-
dc.titleAltered tooth morphogenesis after silencing the planar cell polarity core component, Vangl2-
dc.typeArticle-
dc.identifier.emailWu, Z: zhaomin9@hku.hk-
dc.identifier.emailEpasinghe, DJ: jeevani@hku.hk-
dc.identifier.emailGreen, DW: dwgreen@hku.hk-
dc.identifier.emailJung, HS: hsjung@hku.hk-
dc.identifier.authorityWu, Z=rp02927-
dc.identifier.authorityGreen, DW=rp01598-
dc.identifier.authorityJung, HS=rp01683-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00441-016-2489-4-
dc.identifier.pmid27590885-
dc.identifier.scopuseid_2-s2.0-84984922359-
dc.identifier.hkuros268394-
dc.identifier.volume366-
dc.identifier.issue3-
dc.identifier.spage617-
dc.identifier.epage621-
dc.identifier.eissn1432-0878-
dc.identifier.isiWOS:000389238700009-
dc.publisher.placeGermany-
dc.identifier.issnl0302-766X-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats