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Book Chapter: Gene Delivery for the Generation of Bioartificial Pacemaker

TitleGene Delivery for the Generation of Bioartificial Pacemaker
Authors
KeywordsAdenoassociated virus
Adenovirus
Bioartificial pacemaker
Complete heart block
Gene transfer
Heart rhythms
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel
Sick sinus syndrome
Issue Date2017
PublisherHumana Press
Citation
Gene Delivery for the Generation of Bioartificial Pacemaker. In Kiyotake Ishikawa (Ed.), Cardiac Gene Therapy: Methods and Protocols, p. 293-306. New York, NY: Humana Press, 2017 How to Cite?
AbstractElectronic pacemakers have been used in patients with heart rhythm disorders for device-supported pacing. While effective, there are such shortcomings as limited battery life, permanent implantation of catheters, the lack of autonomic neurohumoral responses, and risks of lead dislodging. Here we describe protocols for establishing porcine models of sick sinus syndrome and complete heart block, and the generation of bioartificial pacemaker by delivering a strategically engineered form of hyperpolarization-activated cyclic nucleotide-gated pacemaker channel protein via somatic gene transfer to convert atrial or ventricular muscle cardiomyocytes into nodal-like cells that rhythmically fire action potentials.
Persistent Identifierhttp://hdl.handle.net/10722/234403
ISBN
ISSN
2023 SCImago Journal Rankings: 0.399
Series/Report no.Methods in Molecular Biology ; v. 1521

 

DC FieldValueLanguage
dc.contributor.authorChan, KWP-
dc.contributor.authorLi, RA-
dc.date.accessioned2016-10-14T13:46:39Z-
dc.date.available2016-10-14T13:46:39Z-
dc.date.issued2017-
dc.identifier.citationGene Delivery for the Generation of Bioartificial Pacemaker. In Kiyotake Ishikawa (Ed.), Cardiac Gene Therapy: Methods and Protocols, p. 293-306. New York, NY: Humana Press, 2017-
dc.identifier.isbn9781493965861-
dc.identifier.issn1064-3745-
dc.identifier.urihttp://hdl.handle.net/10722/234403-
dc.description.abstractElectronic pacemakers have been used in patients with heart rhythm disorders for device-supported pacing. While effective, there are such shortcomings as limited battery life, permanent implantation of catheters, the lack of autonomic neurohumoral responses, and risks of lead dislodging. Here we describe protocols for establishing porcine models of sick sinus syndrome and complete heart block, and the generation of bioartificial pacemaker by delivering a strategically engineered form of hyperpolarization-activated cyclic nucleotide-gated pacemaker channel protein via somatic gene transfer to convert atrial or ventricular muscle cardiomyocytes into nodal-like cells that rhythmically fire action potentials.-
dc.languageeng-
dc.publisherHumana Press-
dc.relation.ispartofCardiac Gene Therapy: Methods and Protocols-
dc.relation.ispartofseriesMethods in Molecular Biology ; v. 1521-
dc.subjectAdenoassociated virus-
dc.subjectAdenovirus-
dc.subjectBioartificial pacemaker-
dc.subjectComplete heart block-
dc.subjectGene transfer-
dc.subjectHeart rhythms-
dc.subjectHyperpolarization-activated cyclic nucleotide-gated (HCN) channel-
dc.subjectSick sinus syndrome-
dc.titleGene Delivery for the Generation of Bioartificial Pacemaker-
dc.typeBook_Chapter-
dc.identifier.emailChan, KWP: pazhi@hku.hk-
dc.identifier.emailLi, RA: ronaldli@hkucc.hku.hk-
dc.identifier.authorityLi, RA=rp01352-
dc.identifier.doi10.1007/978-1-4939-6588-5_21-
dc.identifier.scopuseid_2-s2.0-85005963694-
dc.identifier.hkuros268215-
dc.identifier.volume1521-
dc.identifier.spage293-
dc.identifier.epage306-
dc.identifier.eissn1940-6029-
dc.publisher.placeNew York, NY-
dc.identifier.issnl1064-3745-

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