File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.2217/17520363.2.4.409
- Scopus: eid_2-s2.0-54849417812
- WOS: WOS:000259832300012
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Role of the NF-κB transcriptome and proteome as biomarkers human head and neck squamous cell carcinomas
Title | Role of the NF-κB transcriptome and proteome as biomarkers human head and neck squamous cell carcinomas |
---|---|
Authors | |
Keywords | Head and neck cancer NF-κB Proteome Signal pathways Transcriptome |
Issue Date | 2008 |
Publisher | Future Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/bmm |
Citation | Biomarkers in Medicine, 2008, v. 2 n. 4, p. 409-429 How to Cite? |
Abstract | NF-κB is a family of signal-activated transcription factors comprising hetero- or homodimers from five different subunits, NF-κB1, NF-κB2, RELA, cREL and RELB. NF-κBs are normally transiently activated in response to infection or injury, but in cancers are aberrantly activated, regulating a transcriptome of hundreds of genes and corresponding proteome that promote pathogenesis and therapeutic resistance. In head and neck squamous cell carcinomas, an important role of NF-κB in the regulation of the altered transcriptome and proteome has been established, providing a catalog of activating and target genes and proteins that may be useful as biomarkers of alterations in this pathway for this and other cancers. An emerging appreciation that NF-κB and other signal pathways form an altered regulatory network highlights the need to use biomarkers and combine targeted agents for personalized therapy of cancer. |
Persistent Identifier | http://hdl.handle.net/10722/233708 |
ISSN | 2023 Impact Factor: 1.9 2023 SCImago Journal Rankings: 0.481 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chen, Z | - |
dc.contributor.author | Yan, B | - |
dc.contributor.author | Van Waes, C | - |
dc.date.accessioned | 2016-09-20T06:28:36Z | - |
dc.date.available | 2016-09-20T06:28:36Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Biomarkers in Medicine, 2008, v. 2 n. 4, p. 409-429 | - |
dc.identifier.issn | 1752-0363 | - |
dc.identifier.uri | http://hdl.handle.net/10722/233708 | - |
dc.description.abstract | NF-κB is a family of signal-activated transcription factors comprising hetero- or homodimers from five different subunits, NF-κB1, NF-κB2, RELA, cREL and RELB. NF-κBs are normally transiently activated in response to infection or injury, but in cancers are aberrantly activated, regulating a transcriptome of hundreds of genes and corresponding proteome that promote pathogenesis and therapeutic resistance. In head and neck squamous cell carcinomas, an important role of NF-κB in the regulation of the altered transcriptome and proteome has been established, providing a catalog of activating and target genes and proteins that may be useful as biomarkers of alterations in this pathway for this and other cancers. An emerging appreciation that NF-κB and other signal pathways form an altered regulatory network highlights the need to use biomarkers and combine targeted agents for personalized therapy of cancer. | - |
dc.language | eng | - |
dc.publisher | Future Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/bmm | - |
dc.relation.ispartof | Biomarkers in Medicine | - |
dc.rights | Manuscripts that have been submitted for publication and entry into peer review | - |
dc.subject | Head and neck cancer | - |
dc.subject | NF-κB | - |
dc.subject | Proteome | - |
dc.subject | Signal pathways | - |
dc.subject | Transcriptome | - |
dc.title | Role of the NF-κB transcriptome and proteome as biomarkers human head and neck squamous cell carcinomas | - |
dc.type | Article | - |
dc.identifier.email | Yan, B: yanbin14@hku.hk | - |
dc.identifier.authority | Yan, B=rp01940 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.2217/17520363.2.4.409 | - |
dc.identifier.scopus | eid_2-s2.0-54849417812 | - |
dc.identifier.volume | 2 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 409 | - |
dc.identifier.epage | 429 | - |
dc.identifier.isi | WOS:000259832300012 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1752-0363 | - |