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- Publisher Website: 10.1038/tp.2015.162
- Scopus: eid_2-s2.0-84946232353
- PMID: 26529422
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Article: Neural mediator of the schizotypy-antisocial behavior relationship
Title | Neural mediator of the schizotypy-antisocial behavior relationship |
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Authors | |
Issue Date | 2015 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/tp/index.html |
Citation | Translational Psychiatry, 2015, v. 5 n. 11, article no. e669, p. 1-7 How to Cite? |
Abstract | Prior studies have established that schizotypal personality traits (schizotypy) were associated with antisocial behavior (crime), but it is unclear what neural factors mediate this relationship. This study assessed the mediating effect that sub-regional prefrontal gray, specifically the orbitofrontal gray matter volume, has on the schizotypy–antisocial behavior relationship. Five prefrontal sub-regional (superior, middle, inferior, orbitofrontal and rectal gyral) gray matter volumes were assessed using structural magnetic resonance imaging in 90 adults from the community, together with schizotypy and antisocial behavior. Among all five prefrontal sub-regions, the orbitofrontal cortex (OFC) was the major region-of-interest in the present study. Mediation analyses showed that orbitofrontal gray fully mediated the association between schizotypy and antisocial behavior. After having controlled the sex, age, socio-economic statuses, whole brain volumes and substance abuse/dependence of test subjects, the orbitofrontal gray still significantly mediated the effect of schizotypy on antisocial behavior by 53.5%. These findings are the first that document a neural mediator of the schizotypy–antisocial behavior relationship. Findings also suggest that functions subserved by the OFC, including impulse control and inhibition, emotion processing and decision-making, may contribute to the above comorbidity. |
Persistent Identifier | http://hdl.handle.net/10722/232960 |
ISSN | 2023 Impact Factor: 5.8 2023 SCImago Journal Rankings: 2.203 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lam, BYH | - |
dc.contributor.author | Yang, Y | - |
dc.contributor.author | Raine, A | - |
dc.contributor.author | Lee, TMC | - |
dc.date.accessioned | 2016-09-20T05:33:38Z | - |
dc.date.available | 2016-09-20T05:33:38Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Translational Psychiatry, 2015, v. 5 n. 11, article no. e669, p. 1-7 | - |
dc.identifier.issn | 2158-3188 | - |
dc.identifier.uri | http://hdl.handle.net/10722/232960 | - |
dc.description.abstract | Prior studies have established that schizotypal personality traits (schizotypy) were associated with antisocial behavior (crime), but it is unclear what neural factors mediate this relationship. This study assessed the mediating effect that sub-regional prefrontal gray, specifically the orbitofrontal gray matter volume, has on the schizotypy–antisocial behavior relationship. Five prefrontal sub-regional (superior, middle, inferior, orbitofrontal and rectal gyral) gray matter volumes were assessed using structural magnetic resonance imaging in 90 adults from the community, together with schizotypy and antisocial behavior. Among all five prefrontal sub-regions, the orbitofrontal cortex (OFC) was the major region-of-interest in the present study. Mediation analyses showed that orbitofrontal gray fully mediated the association between schizotypy and antisocial behavior. After having controlled the sex, age, socio-economic statuses, whole brain volumes and substance abuse/dependence of test subjects, the orbitofrontal gray still significantly mediated the effect of schizotypy on antisocial behavior by 53.5%. These findings are the first that document a neural mediator of the schizotypy–antisocial behavior relationship. Findings also suggest that functions subserved by the OFC, including impulse control and inhibition, emotion processing and decision-making, may contribute to the above comorbidity. | - |
dc.language | eng | - |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/tp/index.html | - |
dc.relation.ispartof | Translational Psychiatry | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Neural mediator of the schizotypy-antisocial behavior relationship | - |
dc.type | Article | - |
dc.identifier.email | Lee, TMC: tmclee@hku.hk | - |
dc.identifier.authority | Yang, Y=rp02224 | - |
dc.identifier.authority | Raine, A=rp02224 | - |
dc.identifier.authority | Lee, TMC=rp00564 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/tp.2015.162 | - |
dc.identifier.pmid | 26529422 | - |
dc.identifier.pmcid | PMC5068757 | - |
dc.identifier.scopus | eid_2-s2.0-84946232353 | - |
dc.identifier.hkuros | 264881 | - |
dc.identifier.volume | 5 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | article no. e669, p. 1 | - |
dc.identifier.epage | article no. e669, p. 7 | - |
dc.identifier.isi | WOS:000367665500001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2158-3188 | - |