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Article: A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses

TitleA novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses
Authors
Issue Date2016
PublisherNature Publishing Group: Open Access Journals. The Journal's web site is located at http://www.nature.com/srep/index.html
Citation
Scientific Reports, 2016, v. 6, p. article no. 22008 How to Cite?
AbstractA safe, potent and broad-spectrum antiviral is urgently needed to combat emerging respiratory viruses. In light of the broad antiviral activity of β-defensins, we tested the antiviral activity of 11 peptides derived from mouse β-defensin-4 and found that a short peptide, P9, exhibited potent and broad-spectrum antiviral effects against multiple respiratory viruses in vitro and in vivo, including influenza A virus H1N1, H3N2, H5N1, H7N7, H7N9, SARS-CoV and MERS-CoV. The antiviral activity of P9 was attributed to its high-affinity binding to viral glycoproteins, as well as the abundance of basic amino acids in its composition. After binding viral particles through viral surface glycoproteins, P9 entered into cells together with the viruses via endocytosis and prevented endosomal acidification, which blocked membrane fusion and subsequent viral RNA release. This study has paved the avenue for developing new prophylactic and therapeutic agents with broad-spectrum antiviral activities.
Persistent Identifierhttp://hdl.handle.net/10722/231632
ISSN
2019 Impact Factor: 3.998
2015 SCImago Journal Rankings: 2.073
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhao, H-
dc.contributor.authorZhou, J-
dc.contributor.authorZhang, K-
dc.contributor.authorChu, H-
dc.contributor.authorLiu, D-
dc.contributor.authorPoon, VKM-
dc.contributor.authorChan, CCS-
dc.contributor.authorLeung, HC-
dc.contributor.authorNg, F-
dc.contributor.authorLin, YP-
dc.contributor.authorZhang, AJ-
dc.contributor.authorJin, D-
dc.contributor.authorYuen, KY-
dc.contributor.authorZheng, B-
dc.date.accessioned2016-09-20T05:24:29Z-
dc.date.available2016-09-20T05:24:29Z-
dc.date.issued2016-
dc.identifier.citationScientific Reports, 2016, v. 6, p. article no. 22008-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10722/231632-
dc.description.abstractA safe, potent and broad-spectrum antiviral is urgently needed to combat emerging respiratory viruses. In light of the broad antiviral activity of β-defensins, we tested the antiviral activity of 11 peptides derived from mouse β-defensin-4 and found that a short peptide, P9, exhibited potent and broad-spectrum antiviral effects against multiple respiratory viruses in vitro and in vivo, including influenza A virus H1N1, H3N2, H5N1, H7N7, H7N9, SARS-CoV and MERS-CoV. The antiviral activity of P9 was attributed to its high-affinity binding to viral glycoproteins, as well as the abundance of basic amino acids in its composition. After binding viral particles through viral surface glycoproteins, P9 entered into cells together with the viruses via endocytosis and prevented endosomal acidification, which blocked membrane fusion and subsequent viral RNA release. This study has paved the avenue for developing new prophylactic and therapeutic agents with broad-spectrum antiviral activities.-
dc.languageeng-
dc.publisherNature Publishing Group: Open Access Journals. The Journal's web site is located at http://www.nature.com/srep/index.html-
dc.relation.ispartofScientific Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleA novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses-
dc.typeArticle-
dc.identifier.emailZhao, H: hjzhao13@hku.hk-
dc.identifier.emailZhou, J: jiezhou@hku.hk-
dc.identifier.emailChu, H: hinchu@hku.hk-
dc.identifier.emailPoon, KM: vinpoon@hku.hk-
dc.identifier.emailChan, CS: cschan@hku.hk-
dc.identifier.emailNg, F: fng@hku.hk-
dc.identifier.emailZhang, J: zhangajx@hkucc.hku.hk-
dc.identifier.emailJin, D: dyjin@hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.emailZheng, B: bzheng@hkucc.hku.hk-
dc.identifier.authorityZhou, J=rp01412-
dc.identifier.authorityChu, H=rp02125-
dc.identifier.authorityZhang, J=rp00413-
dc.identifier.authorityJin, D=rp00452-
dc.identifier.authorityYuen, KY=rp00366-
dc.identifier.authorityZheng, B=rp00353-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/srep22008-
dc.identifier.pmid26911565-
dc.identifier.pmcidPMC4766503-
dc.identifier.scopuseid_2-s2.0-84959422192-
dc.identifier.hkuros266274-
dc.identifier.volume6-
dc.identifier.spagearticle no. 22008-
dc.identifier.epagearticle no. 22008-
dc.identifier.isiWOS:000370796800001-
dc.publisher.placeUnited Kingdom-

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