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- Publisher Website: 10.1128/JCM.01007-08
- Scopus: eid_2-s2.0-53649104317
- PMID: 18701660
- WOS: WOS:000259758900029
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Article: Disease severity associated with presence in subgingival plaque of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Tannerella forsythia, singly or in combination, as detected by nested multiplex PCR
Title | Disease severity associated with presence in subgingival plaque of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Tannerella forsythia, singly or in combination, as detected by nested multiplex PCR |
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Authors | |
Issue Date | 2008 |
Citation | Journal of Clinical Microbiology, 2008, v. 46, n. 10, p. 3380-3383 How to Cite? |
Abstract | This study used a nested multiplex PCR method to detect three periodontal pathogens in subgingival plaque collected before treatment and at 2 and 6 months posttreatment from 107 patients with severe, generalized periodontitis. The proportions of the patients who harbored these bacteria before periodontal treatment were as follows: Tannerella forsythia, 81%; Porphyromonas gingivalis, 78%; and Aggregatibacter (formerly Actinobacillus) actinomycetemcomitans, 47%. At 2 months posttreatment there was a significant reduction in the numbers of patients harboring P. gingivalis (46%; P < 0.001) or T. forsythia (63%; P = 0.043) but not A. actinomycetemcomitans (50%) compared to pretreatment data. At 6 months posttreatment, significantly fewer patients harbored P. gingivalis (43%; P < 0.001); A. actinomycetemcomitans, (31%; P = 0.025), or T. forsythia (63%; P = 0.030). Interestingly, at baseline and at 2 months posttherapy, subjects who harbored only a single pathogen had a greater level of periodontal disease than subjects who harbored two, or all three, of these periodontal pathogens. These data suggest that a reduction in the number of species present may be associated with an increase in the severity of periodontal diseases. Copyright © 2008, American Society for Microbiology. All Rights Reserved. |
Persistent Identifier | http://hdl.handle.net/10722/230826 |
ISSN | 2023 Impact Factor: 6.1 2023 SCImago Journal Rankings: 1.653 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ready, D. | - |
dc.contributor.author | D'Aiuto, F. | - |
dc.contributor.author | Spratt, D. A. | - |
dc.contributor.author | Suvan, J. | - |
dc.contributor.author | Tonetti, M. S. | - |
dc.contributor.author | Wilson, M. | - |
dc.date.accessioned | 2016-09-01T06:06:54Z | - |
dc.date.available | 2016-09-01T06:06:54Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Journal of Clinical Microbiology, 2008, v. 46, n. 10, p. 3380-3383 | - |
dc.identifier.issn | 0095-1137 | - |
dc.identifier.uri | http://hdl.handle.net/10722/230826 | - |
dc.description.abstract | This study used a nested multiplex PCR method to detect three periodontal pathogens in subgingival plaque collected before treatment and at 2 and 6 months posttreatment from 107 patients with severe, generalized periodontitis. The proportions of the patients who harbored these bacteria before periodontal treatment were as follows: Tannerella forsythia, 81%; Porphyromonas gingivalis, 78%; and Aggregatibacter (formerly Actinobacillus) actinomycetemcomitans, 47%. At 2 months posttreatment there was a significant reduction in the numbers of patients harboring P. gingivalis (46%; P < 0.001) or T. forsythia (63%; P = 0.043) but not A. actinomycetemcomitans (50%) compared to pretreatment data. At 6 months posttreatment, significantly fewer patients harbored P. gingivalis (43%; P < 0.001); A. actinomycetemcomitans, (31%; P = 0.025), or T. forsythia (63%; P = 0.030). Interestingly, at baseline and at 2 months posttherapy, subjects who harbored only a single pathogen had a greater level of periodontal disease than subjects who harbored two, or all three, of these periodontal pathogens. These data suggest that a reduction in the number of species present may be associated with an increase in the severity of periodontal diseases. Copyright © 2008, American Society for Microbiology. All Rights Reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Clinical Microbiology | - |
dc.title | Disease severity associated with presence in subgingival plaque of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Tannerella forsythia, singly or in combination, as detected by nested multiplex PCR | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1128/JCM.01007-08 | - |
dc.identifier.pmid | 18701660 | - |
dc.identifier.scopus | eid_2-s2.0-53649104317 | - |
dc.identifier.volume | 46 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 3380 | - |
dc.identifier.epage | 3383 | - |
dc.identifier.isi | WOS:000259758900029 | - |
dc.identifier.issnl | 0095-1137 | - |