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- Publisher Website: 10.1111/j.1600-0765.2004.00741.x
- Scopus: eid_2-s2.0-4644308729
- PMID: 15324349
- WOS: WOS:000223471100002
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Article: Periodontal therapy: A novel non-drug-induced experimental model to study human inflammation
Title | Periodontal therapy: A novel non-drug-induced experimental model to study human inflammation |
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Authors | |
Keywords | Interleukin-6 Interleukin-1 receptor antagonist Inflammation C-reactive protein Periodontitis Endotoxin-challenge |
Issue Date | 2004 |
Citation | Journal of Periodontal Research, 2004, v. 39, n. 5, p. 294-299 How to Cite? |
Abstract | Background: Chronic periodontitis causes a low-grade systemic inflammatory response; its standard treatment, however, induces an acute inflammatory response. The aim of this study was to describe the systemic inflammatory reactions to an intensive periodontal treatment regimen. Methods: Fourteen otherwise healthy subjects suffering from severe chronic periodontitis were enrolled in a 1 month pilot single-blind trial. Intensive periodontal treatment, consisting of full-mouth subgingival root debridement delivered within a 6-h period, was performed. Periodontal parameters were recorded before and 1 month after completion of treatment. Blood samples were taken at baseline and 1, 3, 5, 7 and 30 days after treatment. Interleukin-1 receptor antagonist (IL-1Ra), Interleukin-6 (IL-6) and C-reactive protein (CRP) serum concentrations were determined by enzyme-linked immunosorbent assay (ELISA). Complete blood counts were also performed. Results: One day after treatment, mild neutrophilia and monocytosis (p < 0.05) and lymphopenia (p < 0.01) were accompanied by a sharp increase in inflammatory markers (IL-1Ra, IL-6, p < 0.01). A 10-fold increase in CRP (p < 0.001) was detected on day 1 and its kinetics followed a pattern of a classical acute phase response (significantly raised concentrations up to 1 week, p < 0.01). At 3-7 days after treatment, subjects presented also with a mild tendency towards a normocytic anaemic state (p < 0.01) and a degree of lympho-thrombocytosis (p < 0.05). The observed changes were similar to those expected following the well-characterized endotoxin-challenge model of inflammation. Conclusions: Intensive periodontal treatment produced an acute systemic inflammatory response of 1 week duration and might represent an alternative to classic endotoxin-challenge or drug-induced models to study acute inflammation in humans. © Blackwell Munksgaard 2004. |
Persistent Identifier | http://hdl.handle.net/10722/230817 |
ISSN | 2023 Impact Factor: 3.4 2023 SCImago Journal Rankings: 0.895 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | D'Aiuto, F. | - |
dc.contributor.author | Nibali, L. | - |
dc.contributor.author | Mohamed-Ali, V. | - |
dc.contributor.author | Vallance, P. | - |
dc.contributor.author | Tonetti, M. S. | - |
dc.date.accessioned | 2016-09-01T06:06:52Z | - |
dc.date.available | 2016-09-01T06:06:52Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Journal of Periodontal Research, 2004, v. 39, n. 5, p. 294-299 | - |
dc.identifier.issn | 0022-3484 | - |
dc.identifier.uri | http://hdl.handle.net/10722/230817 | - |
dc.description.abstract | Background: Chronic periodontitis causes a low-grade systemic inflammatory response; its standard treatment, however, induces an acute inflammatory response. The aim of this study was to describe the systemic inflammatory reactions to an intensive periodontal treatment regimen. Methods: Fourteen otherwise healthy subjects suffering from severe chronic periodontitis were enrolled in a 1 month pilot single-blind trial. Intensive periodontal treatment, consisting of full-mouth subgingival root debridement delivered within a 6-h period, was performed. Periodontal parameters were recorded before and 1 month after completion of treatment. Blood samples were taken at baseline and 1, 3, 5, 7 and 30 days after treatment. Interleukin-1 receptor antagonist (IL-1Ra), Interleukin-6 (IL-6) and C-reactive protein (CRP) serum concentrations were determined by enzyme-linked immunosorbent assay (ELISA). Complete blood counts were also performed. Results: One day after treatment, mild neutrophilia and monocytosis (p < 0.05) and lymphopenia (p < 0.01) were accompanied by a sharp increase in inflammatory markers (IL-1Ra, IL-6, p < 0.01). A 10-fold increase in CRP (p < 0.001) was detected on day 1 and its kinetics followed a pattern of a classical acute phase response (significantly raised concentrations up to 1 week, p < 0.01). At 3-7 days after treatment, subjects presented also with a mild tendency towards a normocytic anaemic state (p < 0.01) and a degree of lympho-thrombocytosis (p < 0.05). The observed changes were similar to those expected following the well-characterized endotoxin-challenge model of inflammation. Conclusions: Intensive periodontal treatment produced an acute systemic inflammatory response of 1 week duration and might represent an alternative to classic endotoxin-challenge or drug-induced models to study acute inflammation in humans. © Blackwell Munksgaard 2004. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Periodontal Research | - |
dc.subject | Interleukin-6 | - |
dc.subject | Interleukin-1 receptor antagonist | - |
dc.subject | Inflammation | - |
dc.subject | C-reactive protein | - |
dc.subject | Periodontitis | - |
dc.subject | Endotoxin-challenge | - |
dc.title | Periodontal therapy: A novel non-drug-induced experimental model to study human inflammation | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/j.1600-0765.2004.00741.x | - |
dc.identifier.pmid | 15324349 | - |
dc.identifier.scopus | eid_2-s2.0-4644308729 | - |
dc.identifier.volume | 39 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 294 | - |
dc.identifier.epage | 299 | - |
dc.identifier.isi | WOS:000223471100002 | - |
dc.identifier.issnl | 0022-3484 | - |