File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Acute effects of periodontal therapy on bio-markers of vascular health

TitleAcute effects of periodontal therapy on bio-markers of vascular health
Authors
KeywordsExperimental model
Inflammation
Coagulation
Periodontitis
Endothelial cell activation
Issue Date2007
Citation
Journal of Clinical Periodontology, 2007, v. 34, n. 2, p. 124-129 How to Cite?
AbstractAim: We aimed to study the impact of periodontal therapy on several bio-markers related to vascular health. Material and Methods: Fifty-five consecutive subjects (age range 30-64 years) having severe periodontitis received an intensive session of periodontal therapy under local anaesthesia and provided blood samples before and 1 and 7 and 30 days following therapy. High-sensitivity assays were utilized to quantify serum concentrations of inflammatory markers [interleukin(IL)-1β, tumour necrosis factor-α], plasma haemostatic (D-dimer) and endothelial soluble markers [soluble E-selectin(s-Es) and von Willebrand factor antigen (r-WF:Ag)]. Results: Periodontal therapy elicited a significant activation of the haemostatic system (38% and 68% mean increases of plasma D-dimer 1 and 7 days after therapy, respectively, p<0.001), together with moderate endothelial dysfunction (10% and 30% mean increases at 24 h in plasma soluble E-selectin, p<0.05 and von-Willebrand factor, p<0.01, respectively). D-Dimer and s-Es acute changes were significantly correlated with periodontal treatment time (p<0.05). Cigarette smoking status and body mass index strongly influenced the acute release of IL-1β (p<0.05), D-dimer (p<0.01) and s-Es (p<0.01). Conclusions: Periodontal therapy represents a novel and reliable non-drug-induced model to investigate in vivo the interplay between inflammation, coagulation and endothelial cell activation. © 2006 Blackwell Munksgaard.
Persistent Identifierhttp://hdl.handle.net/10722/230773
ISSN
2023 Impact Factor: 5.8
2023 SCImago Journal Rankings: 2.249
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorD'Aiuto, Francesco-
dc.contributor.authorParkar, M.-
dc.contributor.authorTonetti, Maurizio S.-
dc.date.accessioned2016-09-01T06:06:46Z-
dc.date.available2016-09-01T06:06:46Z-
dc.date.issued2007-
dc.identifier.citationJournal of Clinical Periodontology, 2007, v. 34, n. 2, p. 124-129-
dc.identifier.issn0303-6979-
dc.identifier.urihttp://hdl.handle.net/10722/230773-
dc.description.abstractAim: We aimed to study the impact of periodontal therapy on several bio-markers related to vascular health. Material and Methods: Fifty-five consecutive subjects (age range 30-64 years) having severe periodontitis received an intensive session of periodontal therapy under local anaesthesia and provided blood samples before and 1 and 7 and 30 days following therapy. High-sensitivity assays were utilized to quantify serum concentrations of inflammatory markers [interleukin(IL)-1β, tumour necrosis factor-α], plasma haemostatic (D-dimer) and endothelial soluble markers [soluble E-selectin(s-Es) and von Willebrand factor antigen (r-WF:Ag)]. Results: Periodontal therapy elicited a significant activation of the haemostatic system (38% and 68% mean increases of plasma D-dimer 1 and 7 days after therapy, respectively, p<0.001), together with moderate endothelial dysfunction (10% and 30% mean increases at 24 h in plasma soluble E-selectin, p<0.05 and von-Willebrand factor, p<0.01, respectively). D-Dimer and s-Es acute changes were significantly correlated with periodontal treatment time (p<0.05). Cigarette smoking status and body mass index strongly influenced the acute release of IL-1β (p<0.05), D-dimer (p<0.01) and s-Es (p<0.01). Conclusions: Periodontal therapy represents a novel and reliable non-drug-induced model to investigate in vivo the interplay between inflammation, coagulation and endothelial cell activation. © 2006 Blackwell Munksgaard.-
dc.languageeng-
dc.relation.ispartofJournal of Clinical Periodontology-
dc.subjectExperimental model-
dc.subjectInflammation-
dc.subjectCoagulation-
dc.subjectPeriodontitis-
dc.subjectEndothelial cell activation-
dc.titleAcute effects of periodontal therapy on bio-markers of vascular health-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-051X.2006.01037.x-
dc.identifier.pmid17214734-
dc.identifier.scopuseid_2-s2.0-33846350187-
dc.identifier.volume34-
dc.identifier.issue2-
dc.identifier.spage124-
dc.identifier.epage129-
dc.identifier.eissn1600-051X-
dc.identifier.isiWOS:000243533500005-
dc.identifier.issnl0303-6979-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats