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- Publisher Website: 10.1016/0167-4889(90)90236-7
- Scopus: eid_2-s2.0-0025041540
- PMID: 2400780
- WOS: WOS:A1990DZ01600003
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Article: Receptor-stimulated actin polymerization requires cytoplasmic acidification in human PMNs
| Title | Receptor-stimulated actin polymerization requires cytoplasmic acidification in human PMNs |
|---|---|
| Authors | |
| Keywords | Cell movement Hydrogen-ion concentration Cytoskeleton Granulocyte |
| Issue Date | 1990 |
| Citation | BBA - Molecular Cell Research, 1990, v. 1054, n. 2, p. 154-158 How to Cite? |
| Abstract | Cytoplasmic alkalinization has received considerable attention as a regulatory event In cell growth, transformation and signal transduction (Busa, W.B. (1986) Annu. Rev. Physiol. 48, 389-402 and Moolenar, W.H. (1986) Annu. Rev. Physiol. 48, 363-376). In contrast the current paper presents evidence for the role of an early cytoplasmic acidification, during signal transduction in the polymorphonuclear leukocyte (PMN). Following PMN stimulation with a chemotactic peptide, there is a significant decrease in cytoplasmic pH concomitant with a dramatic increase in cytoskeletal actin. The data indicate that this drop in pHi is necessary, but not sufficient, for signal transduction leading to cytoskeletal reorganization in these cells. © 1990. |
| Persistent Identifier | http://hdl.handle.net/10722/230644 |
| ISSN | 2023 Impact Factor: 4.6 2023 SCImago Journal Rankings: 1.500 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Tonetti, Maurizio | - |
| dc.contributor.author | Budnick, Michael | - |
| dc.contributor.author | Niederman, Richard | - |
| dc.date.accessioned | 2016-09-01T06:06:27Z | - |
| dc.date.available | 2016-09-01T06:06:27Z | - |
| dc.date.issued | 1990 | - |
| dc.identifier.citation | BBA - Molecular Cell Research, 1990, v. 1054, n. 2, p. 154-158 | - |
| dc.identifier.issn | 0167-4889 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/230644 | - |
| dc.description.abstract | Cytoplasmic alkalinization has received considerable attention as a regulatory event In cell growth, transformation and signal transduction (Busa, W.B. (1986) Annu. Rev. Physiol. 48, 389-402 and Moolenar, W.H. (1986) Annu. Rev. Physiol. 48, 363-376). In contrast the current paper presents evidence for the role of an early cytoplasmic acidification, during signal transduction in the polymorphonuclear leukocyte (PMN). Following PMN stimulation with a chemotactic peptide, there is a significant decrease in cytoplasmic pH concomitant with a dramatic increase in cytoskeletal actin. The data indicate that this drop in pHi is necessary, but not sufficient, for signal transduction leading to cytoskeletal reorganization in these cells. © 1990. | - |
| dc.language | eng | - |
| dc.relation.ispartof | BBA - Molecular Cell Research | - |
| dc.subject | Cell movement | - |
| dc.subject | Hydrogen-ion concentration | - |
| dc.subject | Cytoskeleton | - |
| dc.subject | Granulocyte | - |
| dc.title | Receptor-stimulated actin polymerization requires cytoplasmic acidification in human PMNs | - |
| dc.type | Article | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1016/0167-4889(90)90236-7 | - |
| dc.identifier.pmid | 2400780 | - |
| dc.identifier.scopus | eid_2-s2.0-0025041540 | - |
| dc.identifier.volume | 1054 | - |
| dc.identifier.issue | 2 | - |
| dc.identifier.spage | 154 | - |
| dc.identifier.epage | 158 | - |
| dc.identifier.isi | WOS:A1990DZ01600003 | - |
| dc.identifier.issnl | 0167-4889 | - |